orabase and Foot-Ulcer

While pressure relief is a vital component of the treatment of neuropathic plantar foot ulcers, many patients are reluctant to wear offloading devices. Healing is more likely to occur if the patient is happy with its appearance and comfort.

Topics: Biomechanical Phenomena; Carboxymethylcellulose Sodium; Debridement; Foot Ulcer; Holistic Health; Humans; Male; Middle Aged; Nursing Assessment; Patient Compliance; Peripheral Nervous System Diseases; Pressure; Risk Factors; Shoes; Skin Care; Treatment Outcome; Walkers; Wound Healing

Multicentric trial to test the efficacy of the combined use of two hydrocolloid dressings (AQUACEL + Varihesive Extra Fino) or a hydrocolloid dressing and gauze in the treatment of different aetiology lesions. Includes 1,805 patients with lesions that can be treated with the cure system under study, without wound dimensions or severity restrictions. At the end of the trial period, 78.3% of the lesions reached healing or a significant improvement of their condition, resulting in an increase of patients' quality of life. 90% of patients confirmed their willingness to continue the treatment with AQUACEL.

Topics: Bandages, Hydrocolloid; Carboxymethylcellulose Sodium; Colloids; Foot Ulcer; Humans; Occlusive Dressings; Wound Healing

To test the safety and effectiveness of carboxyl-methyl-cellulose dressing (Aquacel; ConvaTec, UK) in the management of deep diabetic foot ulcers, a group of consecutive out-patients attending the foot clinic of the Department of Metabolic Diseases was studied.. Patients were selected according to the following inclusion criteria: a foot ulcer deeper than 1 cm for > 3 weeks, good peripheral blood supply (palpable peripheral pulses or ABPI > 0.9). Exclusion criteria were as follows: active infection, as evident from clinical signs (purulent discharge, redness, swelling, tenderness) and confirmed by culture exams, plasma creatinine > 2 mg/dl, recent episodes of ketoacidosis, malignancies, and any therapy or pathology which might interfere with the healing process. Twenty patients were enrolled in the study and having obtained their informed consent, their lesions were surgically debrided with the complete elimination of all necrotic tissue and debris up to the bleeding healthy tissue; then ulcers were staged and measured, and patients were randomly assigned to two different treatment groups. Patients in group A were dressed with saline-moistened gauze, while patients in group B were dressed with Aquacel according to the manufacturer's instructions. All patients in both groups received special post-operative shoes (Podiabetes; Zeno Buratto, Treviso, Italy) and crutches until complete re-epithelialization. Ulcers were all left to heal by secondary intent. After 8 weeks patients were blindly evaluated for: the rate of reduction of lesional volume (RLV), rate of granulation tissue (GT), number of infective complications (IC). Intralesional (ILTC) and perilesional (PLTC) temperatures were also recorded with a thermocouple surface digital thermometer, and the difference between the two values (Delta TC) was calculated. Healing time (HT, days), was then compared between the two groups. Data were compared by analysis of variance (ANOVA), linear regression, Kaplan-Meier survival analysis and Fisher's exact test.. HT was significantly shorter in Group B than in Group A (P < 0.001). RLV was significantly (P < 0.01) higher in Group B patients compared with Group A, as well as GT (P < 0.05). IC were in 1/10 Group B and in 3/10 Group A (P = 0.582). In addition, both ILTC and Delta TC were higher in Group B compared with Group A ones (P < 0.01).. Carboxyl-methyl-cellulose dressings were shown to be safe, effective and well tolerated in the management of non-ischaemic, non-infected deep diabetic foot ulcers.

Topics: Adult; Aged; Amputation, Surgical; Bandages; Carboxymethylcellulose Sodium; Crutches; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot; Foot Ulcer; Glycated Hemoglobin; Humans; Middle Aged; Outpatients; Patient Selection; Shoes; Time Factors; Toes; Treatment Outcome; Wound Healing

Topics: Aged; Aged, 80 and over; Carboxymethylcellulose Sodium; Female; Foot Ulcer; Humans; Leg Ulcer; Male; Middle Aged; Wound Healing

Topics: Carboxymethylcellulose Sodium; Combined Modality Therapy; Debridement; Diabetes Mellitus, Type 2; Foot Ulcer; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Toes; Venous Thrombosis; Wound Healing

Topics: Aged; Aged, 80 and over; Bandages, Hydrocolloid; Carboxymethylcellulose Sodium; Chronic Disease; Colloids; Combined Modality Therapy; Foot Ulcer; Humans; Male; Occlusive Dressings