orabase and Edema

The aim of this study was to evaluate and compare the in vitro and in vivo transdermal potential of bioadhesive gels of ketoprofen by using gelling polymers like sodium carboxymethylcellulose, xanthan gum, poloxamer 407 and carbopol 934P as bioadhesive polymer with and without penetration enhancer (oleic acid). The effect of oleic acid as a penetration enhancer was examined when it was added to the bioadhesive formulations. Gels were evaluated for bioadhesive force and viscosity. To study the in vitro potential of these formulations, permeation studies were performed with Franz diffusion cell using excised rat abdominal skin. Carrageenan induced rat paw edema model was used to investigate their in vivo performance. The commercial formulation of ketoprofen was used as a reference formulation. The in vitro permeation studies indicate that ketoprofen bioadhesive gel of poloxamer 407 with penetration enhancer was superior to gels of sodium carboxymethylcellulose and xanthan gum with penetration enhancer (oleic acid). The permeation rate of ketoprofen from poloxamer 407 based bioadhesive gel with 15% v/w penetration enhancer was higher (rat abdominal skin flux = 0.421 +/- 0.032 mg/cm(2)/h) than the permeation rate of sodium carboxymethylcellulose and xanthan gum based bioadhesive gel with 15% v/w penetration enhancer. In the paw edema test poloxamer 407 based bioadhesive gel with 15% v/w penetration enhancer showed the best permeation and effectiveness. The in vitro and in vivo studies showed that bioadhesive gels of ketoprofen could be used for effective therapy.

Topics: Acrylates; Adhesiveness; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxymethylcellulose Sodium; Carrageenan; Chemistry, Pharmaceutical; Disease Models, Animal; Dosage Forms; Drug Carriers; Drug Compounding; Edema; Gels; In Vitro Techniques; Ketoprofen; Kinetics; Male; Oleic Acid; Permeability; Poloxamer; Polymers; Polysaccharides, Bacterial; Rats; Rats, Wistar; Skin; Skin Absorption; Viscosity

Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Carboxymethylcellulose Sodium; Edema; Female; Hemostatic Techniques; Humans; Hyaluronoglucosaminidase; Male; Middle Aged; Rhinophyma; Rhinoplasty; Splints

Dextran, mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with beta-cyclodextrin moieties by reductive alkylation in the presence of sodium borohydride. These polymers were used as supramolecular carriers for naproxen, improving the "in vivo" anti-inflammatory properties of this drug.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Carboxymethylcellulose Sodium; Carcinogens; Carrageenan; Dextrans; Drug Carriers; Edema; Male; Mannans; Naproxen; Oxidation-Reduction; Periodic Acid; Rats; Rats, Wistar

Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.

Topics: Animals; Anti-Inflammatory Agents; beta-Cyclodextrins; Carboxymethylcellulose Sodium; Carrageenan; Cyclodextrins; Edema; Foot; Male; Rats; Rats, Wistar; Superoxide Dismutase

At present no information is available about biological effects on oral tissues of the photocuring periodontal dressing Barricaid. This animal study examines histologically the tissue responses of surgical areas covered during 7 days with either Barricaid, the eugenol-containing dressing Ward's Wondrpak or the bionert control gel Carboxyl Methyl Cellulose. One group was studied immediately after the removal of the dressings; in the other group, further healing was permitted for another week. Results after 7 days indicate acute inflammatory reactions in the test areas without significant differences between the 2 periodontal dressing materials. The control areas showed to a lesser degree basically the same tissue response. In the 2nd week, generally all areas healed. After 14 days, no differences between test- and control sites could be detected. From a biological point of view, these findings suggest no contra-indication for application of this photocuring dressing material after periodontal surgery.

Topics: Animals; Carboxymethylcellulose Sodium; Dogs; Edema; Epithelium; Eugenol; Evaluation Studies as Topic; Hyperemia; Lymphocytes; Neutrophils; Periodontal Dressings; Periodontium; Plasma Cells; Resins, Synthetic; Time Factors; Ulcer; Wound Healing