orabase and Dermatitis--Allergic-Contact

We report a case of severe peristomal dermatitis that was refractory to conventional treatments. Patch testing revealed positive allergies to myroxylon perulase (balsam of Peru), propylene glycol, Stomahesive paste, and Gantrez. This is the second reported case of patch-test-positive peristomal allergy to Gantrez.

Topics: Adolescent; Carboxymethylcellulose Sodium; Colostomy; Dermatitis, Allergic Contact; Dermatologic Agents; Drug Combinations; Female; Gelatin; Humans; Maleates; Ointments; Patch Tests; Pectins; Polyenes; Polyvinyls; Tissue Adhesives

Topics: Aged, 80 and over; Carboxymethylcellulose Sodium; Dermatitis, Allergic Contact; Drug Combinations; Gelatin; Humans; Male; Patch Tests; Pectins; Polyenes; Surgical Stomas

Topics: Carboxymethylcellulose Sodium; Child; Dermatitis, Allergic Contact; Epidermolysis Bullosa Simplex; Humans; Male; Occlusive Dressings

Topics: Adhesives; Aged, 80 and over; Carboxymethylcellulose Sodium; Dermatitis, Allergic Contact; Drug Combinations; Gelatin; Humans; Male; Ostomy; Pectins; Polyenes; Polyethylenes; Skin Ulcer

Topics: Aged; Bandages, Hydrocolloid; Carboxymethylcellulose Sodium; Dermatitis, Allergic Contact; Female; Humans; Leg Ulcer; Occlusive Dressings; Organic Chemicals; Patch Tests

Carboxymethylcellulose (CMC) is widely used in consumer goods, foods, and medicaments as a binder, emulsifier, and viscosity enhancer. Cases of immediate and delayed allergic reactions to this anionic cellulose polymer have been reported.. To report a case of contact urticaria from CMC in chalk, with possible cross-reaction to methyl hydroxyethylcellulose (MHEC).. Patch tests with readings at 48 and 96 hours were performed with the North American Contact Dermatitis Group standard series and benzisothiazolinone. Open and prick tests with readings after 30 minutes were performed with two brands of chalk as well as with various petrolatum and aqueous dilutions of CMC, MHEC, oleic acid, and calcium carbonate.. The patient developed strong urticarial reactions during open tests with both powdered chalks and had milder reactions to the open test with CMC 10% aqueous (aq) and to prick testing with CMC 0.1% aq. No reaction to MHEC or any of the other ingredients of the chalks was observed. No relevant delayed reaction was noted.. CMC can cause contact urticaria. It remains unclear why our patient reacted more strongly to the chalk than to CMC itself. We speculate that the abrasive nature of the chalk enhances the cutaneous penetration of CMC or that calcium carbonate, the main ingredient of the chalk, acts as an adjuvant. It is also possible that CMC and MHEC cross-react and that our negative results with MHEC may be due to improper testing technique or concentrations.

Topics: Adolescent; Calcium Carbonate; Carboxymethylcellulose Sodium; Cross Reactions; Dermatitis, Allergic Contact; Female; Follow-Up Studies; Humans; Hypersensitivity, Immediate; Patch Tests; Risk Assessment; Severity of Illness Index; Urticaria

Topics: Aged; Carboxymethylcellulose Sodium; Dermatitis, Allergic Contact; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; Gelatin; Humans; Male; Pectins; Polyenes

Topics: Aged; Allergens; Bandages; Carboxymethylcellulose Sodium; Colloids; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Humans; Leg Ulcer; Patch Tests; Syndrome; Urticaria

Hydrocolloid wound dressings have been in use for nearly two decades, and have rarely caused allergic contact dermatitis. DuoDERM E (DuoDERM CGF) is a newer version of DuoDERM (ConvaTec Ltd, a division of Bristol-Myers Squibb Co, Princeton, NJ) that contains a sensitizing derivative of colophony.. We describe three patients who developed eczematous lesions under this type of wound covering.. The patients were patch tested to the European standard series, to a glues and adhesives series, and to pieces of various adhesive dressings.. The patients displayed positive patch tests to colophony and to DuoDERM E or DuoDERM CGF hydrocolloid dressings.. These dressings contain the pentaerythritol ester of hydrogenated rosin as a tackifying agent, and this substance retains the sensitizing potential of colophony. The addition of this compound is an important change that may negatively alter the good safety record of ConvaTec dressings.

Topics: Adult; Aged; Bandages, Hydrocolloid; Carboxymethylcellulose Sodium; Colloids; Dermatitis, Allergic Contact; Female; Humans; Male; Occlusive Dressings; Patch Tests; Resins, Plant

Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Carboxymethylcellulose Sodium; Colloids; Dermatitis, Allergic Contact; Drug Eruptions; Family Health; Female; Humans; Ketoprofen; Male