orabase and Carcinoma--Squamous-Cell

Oral lichen planus (OLP) is a chronic mucosal condition commonly encountered in clinical dental practice. Lichen planus is believed to represent an abnormal immune response in which epithelial cells are recognized as foreign, secondary to changes in the antigenicity of the cell surface. It has various oral manifestations, the reticular form being the most common. The erosive and atrophic forms of OLP are less common, yet are most likely to cause symptoms. Topical corticosteroids constitute the mainstay of treatment for symptomatic lesions of OLP. Recalcitrant lesions can be treated with systemic steroids or other systemic medications. However, there is only weak evidence that these treatments are superior to placebo. Given reports of a slightly greater risk of squamous cell carcinoma developing in areas of erosive OLP, it is important for clinicians to maintain a high index of suspicion for all intraoral lichenoid lesions. Periodic follow-up of all patients with OLP is recommended.

Topics: Carboxymethylcellulose Sodium; Carcinoma, Squamous Cell; Chronic Disease; Diagnosis, Differential; Humans; Immunosuppressive Agents; Lichen Planus, Oral; Mouth Neoplasms; Precancerous Conditions; Steroids; Tacrolimus

Radiation treatment of scalp malignancies can be a challenge due to the multiple curved surfaces to which homogenous dose must be delivered. The most readily available techniques utilize linear accelerator-based technique of opposed lateral electron field abutting opposed lateral photon field with central blocking. Bolus material is used to achieve adequate skin dose. Although plans to add bolus material often occur in the virtual setting during treatment planning, the practical aspects of reproducibly maintain the bolus material along curved surfaces during the day-to-day patient setup can be a challenge. We present a case of a patient with squamous cell carcinoma of the scalp with neck node involvement treated with surgery followed by adjuvant radiotherapy. We demonstrate a unique immobilization technique that maintains the bolus material on the aquaplast mesh adherent to the patient's scalp as well as the neck. TomoTherapy with daily megavoltage computed tomography (CT) scan was utilized to verify the daily bolus position. We were able to maintain a 95% reproducibility rate. This technique reliably maintains the bolus material on the desired locations with minimum adjustments and manipulation by the therapist and is a technique that can be universally adaptable for conventional radiotherapy or intensity modulated radiation therapy (IMRT) techniques.

Topics: Carboxymethylcellulose Sodium; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Immobilization; Male; Middle Aged; Radiotherapy Dosage; Reproducibility of Results; Scalp; Sensitivity and Specificity; Skin Neoplasms

To report on the usage of a thermoplastic material in eyelid reconstruction.. Retrospective single-surgeon case review.. Thirty-eight full-thickness skin grafts in 37 patients are reported. No major complications were encountered. All outcomes with the use of this technique yielded satisfactory results.. The use of thermoplastic materials in eyelid reconstruction appears to achieve results equal to those seen with traditional materials. This technique in eyelid surgery may save operative time and be less expensive than traditional methods.

Topics: Aged; Blepharoplasty; Carboxymethylcellulose Sodium; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Ectropion; Eyelid Neoplasms; Eyelids; Female; Humans; Male; Retrospective Studies; Sebaceous Gland Neoplasms; Skin Transplantation; Splints

A method for induction of carcinoma in subcutaneously implanted bronchial autografts in dogs is described. Four to 6 weeks after successful bronchial autografting, 30 to 90 mg. amounts of 3-MC or B(a)P suspended in sterile saline solution containing 1 percent CMC was injected into the lumen of the graft. The mucosal changes were followed histologically by excision of biopsy specimens and cytologically by needle aspiration biopsies. Three dogs developed squamous cell carcinomas invading deep into the submucosal area as early as 13 to 30 weeks after the first carcinogen treatment. The remaining eight experimental dogs showed various grades of squamous cell metaplasia with atypia within 30 weeks. Subsequently examined specimens revealed atypical metaplastic and proliferative changes further advanced than those seen in the initial biopsy specimens. The advantages of this method for a better understanding of the development of bronchogenic carcinomas are discussed.

Topics: Animals; Benzopyrenes; Biopsy, Needle; Bronchi; Bronchial Neoplasms; Carboxymethylcellulose Sodium; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dermatologic Surgical Procedures; Dogs; Drug Implants; Female; Male; Methylcholanthrene; Neoplasms, Experimental; Precancerous Conditions; Time Factors; Transplantation, Autologous