orabase and Carcinogenesis

Inflammation is a well-characterized critical driver of gastrointestinal cancers. Previous findings have shown that intestinal low-grade inflammation can be promoted by the consumption of select dietary emulsifiers, ubiquitous component of processed foods which alter the composition and function of the gut microbiota. Using a model of colitis-associated cancer, we previously reported that consumption of the dietary emulsifiers carboxymethylcellulose or polysorbate-80 exacerbated colonic tumor development. Here, we investigate the impact of dietary emulsifiers consumption on cancer initiation and progression in a genetical model of intestinal adenomas. In APC

Topics: Adenoma; Animals; Carboxymethylcellulose Sodium; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Diet; Emulsifying Agents; Female; Food Additives; Gastrointestinal Microbiome; Gastrointestinal Tract; Inflammation; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Polysorbates