orabase and Agranulocytosis

Several biological response modifiers (BRMs) were demonstrated to increase myelopoiesis and effector cell responses (M phi and natural killer cell activity) in vivo. The increased myelopoiesis was reflected by an increase in bone marrow cellularity and granulocyte-M phi colony-forming cells (GM-CFU-C). The increase in myelopoiesis appeared to be related to a concomitant increase in colony-stimulated factor (CSF) production and secretion by M phi and bone marrow cells. CSF induction by BRMs increased myelopoiesis and counteracted the myelosuppressive and immunosuppressive effects of cyclophosphamide. CSF induced in vivo by BRMs attained high titers and were maintained over a longer period than exogenously injected CSF, which was rapidly cleared from serum.

Topics: Adjuvants, Immunologic; Agranulocytosis; Animals; Aziridines; Carboxymethylcellulose Sodium; Cell Line; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclophosphamide; Cytotoxicity, Immunologic; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred BALB C; Picibanil; Poly I-C; Polylysine; Pyran Copolymer

Topics: Adult; Aged; Agranulocytosis; Carboxymethylcellulose Sodium; Female; Humans; Indomethacin; Interferons; Lymphopenia; Male; Middle Aged; Multiple Myeloma; Poly I-C; Polylysine