opc 21268 has been researched along with Hypertension in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (84.21) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akahoshi, Y; Fujiki, H; Ikeda, T; Iwanaga, Y; Miyazaki, S; Morooka, H; Watanabe, H | 1 |
| Japundzić-Zigon, N; Jovanović, A; Milutinović, S | 1 |
| Abe, K; Hashimoto, J; Imai, Y; Minami, N | 1 |
| Aldred, KL; Burrell, LM; Hutchins, AM; Johnston, CI; Phillips, PA; Risvanis, J | 1 |
| Kanno, Y; Okada, H; Saruta, T; Suzuki, H | 2 |
| Asano, N; Harada, K; Hashimoto, M; Kageyama, J; Mimura, Y; Ogura, T; Oishi, T; Ota, Z; Yamauchi, T | 1 |
| Kanno, Y; Okada, H; Saruta, T; Suzuki, H; Yamamura, Y | 1 |
| Akishita, M; Liang, J; Orimo, H; Ouchi, Y; Toba, K | 1 |
| Burrell, LM; Johnston, CI; Phillips, PA; Risvanis, J; Rolls, KA; Stephenson, JM | 1 |
| Crofton, JT; Ota, M; Share, L | 1 |
| Chihara, T; Mori, T; Nakamura, S; Onogawa, T; Tominaga, M; Yabuuchi, Y; Yamada, Y; Yamamura, Y; Yamashita, T | 1 |
| Abe, K; Hashimoto, J; Imai, Y; Minami, N; Munakata, M | 1 |
| Nakanishi, T; Nanbu, A; Nishimura, M; Sakamoto, M; Takahashi, H; Yoshimura, M | 1 |
| Aldred, KL; Burrell, LM; Johnston, CI; Naitoh, M; Phillips, PA; Risvanis, J; Rockell, MD | 1 |
| Kawano, Y; Matsuoka, H; Nishikimi, T; Omae, T; Takishita, S | 1 |
| Hashimoto, M; Makino, H; Mimura, Y; Ogura, T; Oishi, T; Otsuka, F; Yamauchi, T | 1 |
| He, G; Intengan, HD; Schiffrin, EL | 1 |
| Burrell, LM; Fraser, TB; Li, M; Turner, SW; Wen, C; Whitworth, JA | 1 |
1 trial(s) available for opc 21268 and Hypertension
| Article | Year |
|---|---|
The role of vasopressin in essential hypertension. Plasma levels and effects of the V1 receptor antagonist OPC-21268 during different dietary sodium intakes.
Topics: Adult; Aged; Antidiuretic Hormone Receptor Antagonists; Baroreflex; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Piperidines; Quinolones; Sodium, Dietary; Vasopressins | 1997 |
18 other study(ies) available for opc 21268 and Hypertension
| Article | Year |
|---|---|
Effects of Long-term Blockade of Vasopressin Receptor Types 1a and 2 on Cardiac and Renal Damage in a Rat Model of Hypertensive Heart Failure.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Kidney; Kidney Diseases; Male; Piperidines; Quinolones; Rats, Inbred Dahl; Receptors, Vasopressin; Time Factors; Tolvaptan; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Effects of nonpeptide and selective V1 and V2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Hypertension; Male; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Vasopressin | 2004 |
Contribution of vascular nitric oxide to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Captopril; Endothelium, Vascular; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentolinium Tartrate; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Attenuation of genetic hypertension after short-term vasopressin V1A receptor antagonism.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Body Weight; Female; Hypertension; Male; Piperidines; Quinolones; Ramipril; Rats; Rats, Inbred SHR | 1995 |
Effect of nonpeptide vasopressin receptor antagonists on developing, and established DOCA-salt hypertension in rats.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Body Weight; Desoxycorticosterone; Hypertension; Male; Piperidines; Quinolones; Random Allocation; Rats; Rats, Wistar; Sodium Chloride | 1995 |
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Biomarkers; Blood Pressure; Body Weight; Disease Models, Animal; Diuresis; Glomerulosclerosis, Focal Segmental; Hypertension; Kidney; Male; Nephrectomy; Nephrosclerosis; Piperidines; Proteinuria; Quinolones; Rats; Rats, Inbred SHR | 1995 |
Enhanced pressor response in spontaneously hypertensive rats induced by stimulation of vasopressin-V1 receptors.
Topics: Animals; Arginine Vasopressin; Benzazepines; Blood Pressure; Heart Rate; Hypertension; Male; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Vasopressin; Stimulation, Chemical | 1995 |
Chronic and selective vasopressin blockade in spontaneously hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Hypertension; Male; Osmolar Concentration; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Vasopressin; Urine; Vasopressins | 1994 |
Effect of an intracerebroventricularly administered vasopressin V1 antagonist on blood pressure and heart rate in deoxycorticosterone-salt hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Cardiac Output; Desoxycorticosterone; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Intravenous; Injections, Intraventricular; Male; Microdialysis; Piperidines; Quinolones; Rats; Rats, Wistar | 1994 |
Blood pressure-lowering effect of an orally active vasopressin V1 receptor antagonist in mineralocorticoid hypertension in the rat.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Binding Sites; Blood Pressure; Desoxycorticosterone; Female; Hypertension; Kinetics; Mesenteric Arteries; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Sodium Chloride; Systole; Vascular Resistance | 1994 |
Role of vasopressin, the renin-angiotensin system and sex in Dahl salt-sensitive hypertension.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Captopril; Circadian Rhythm; Diet; Female; Hypertension; Male; Piperidines; Quinolones; Rats; Rats, Mutant Strains; Renin-Angiotensin System; Sex Characteristics; Sodium Chloride; Vasopressins | 1993 |
OPC-21268, a vasopressin V1 antagonist, produces hypotension in spontaneously hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Blood Pressure; Hypertension; Male; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 1994 |
Effects of vasopressin V1 and V2 receptor antagonists on the development of salt-induced hypertension in Dahl rats.
Topics: Analysis of Variance; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Blood Pressure; Blood Pressure Determination; Diuresis; Hypertension; Male; Piperidines; Quinolones; Rats; Sodium Chloride | 1995 |
Cerebral adenosine triphosphate-sensitive K+ channels may be impaired during acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Antihypertensive Agents; Arginine Vasopressin; Arterial Occlusive Diseases; Blood Pressure; Brain Ischemia; Carotid Arteries; Cerebral Cortex; Glyburide; Guanidines; Hypertension; Hypoglycemic Agents; Injections, Intravenous; Injections, Intraventricular; Ligation; Male; Pinacidil; Piperidines; Potassium Channels; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Modulation of genetic hypertension by short-term AVP V1A or V2 receptor antagonism in young SHR.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Blood Pressure; Hypertension; Male; Myocardium; Organ Size; Piperidines; Quinolones; Ramipril; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Systole; Time Factors | 1997 |
Effects of OPC-21268, a vasopressin V1-receptor antagonist, on expression of growth factors from glomeruli in spontaneously hypertensive rats.
Topics: Acetylglucosaminidase; Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Body Weight; Growth Substances; Heart Rate; Hypertension; Kidney Glomerulus; Organ Size; Piperidines; Platelet-Derived Growth Factor; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Proteinuria; Quinolones; Random Allocation; Rats; Rats, Inbred SHR; RNA, Messenger; Sodium; Transforming Growth Factor beta; Urine | 1997 |
Effect of vasopressin antagonism on structure and mechanics of small arteries and vascular expression of endothelin-1 in deoxycorticosterone acetate salt hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Biomechanical Phenomena; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Elasticity; Endothelin-1; Gene Expression; Hypertension; Male; Mesenteric Artery, Superior; Nephrectomy; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Vasodilation | 1998 |
Vasopressin V1a receptor antagonism does not reverse adrenocorticotrophin-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Body Weight; Hematocrit; Hypertension; Male; Organ Size; Osmolar Concentration; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Urodynamics | 2000 |