opc 12759 has been researched along with Sjogren's Syndrome in 7 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " No difference in the incidence of adverse events was seen between the two groups, confirming the safety of rebamipide." | 2.74 | Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjögren's syndrome: a double-blind placebo-controlled multicenter trial. ( Kawakami, A; Koni, I; Nishinarita, M; Nishiyama, S; Ohta, S; Oka, H; Sawada, S; Sugai, S; Sugiyama, E; Takahashi, H; Takei, M; Umehara, H; Yamaji, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jin-Sil, P | 1 |
| Sun-Hee, H | 1 |
| SeungCheon, Y | 1 |
| JeongWon, C | 1 |
| Kyung-Ah, J | 1 |
| Mi-La, C | 1 |
| Sung-Hwan, P | 1 |
| Shoji, J | 1 |
| Inada, N | 1 |
| Tomioka, A | 1 |
| Yamagami, S | 1 |
| Arakaki, R | 2 |
| Eguchi, H | 1 |
| Yamada, A | 1 |
| Kudo, Y | 1 |
| Iwasa, A | 1 |
| Enkhmaa, T | 1 |
| Hotta, F | 1 |
| Mitamura-Aizawa, S | 1 |
| Mitamura, Y | 1 |
| Hayashi, Y | 2 |
| Ishimaru, N | 2 |
| Arimoto, A | 1 |
| Kitagawa, K | 1 |
| Mita, N | 1 |
| Takahashi, Y | 1 |
| Shibuya, E | 1 |
| Sasaki, H | 1 |
| Kapoor, S | 1 |
| Sugai, S | 1 |
| Takahashi, H | 1 |
| Ohta, S | 1 |
| Nishinarita, M | 1 |
| Takei, M | 1 |
| Sawada, S | 1 |
| Yamaji, K | 1 |
| Oka, H | 1 |
| Umehara, H | 1 |
| Koni, I | 1 |
| Sugiyama, E | 1 |
| Nishiyama, S | 1 |
| Kawakami, A | 1 |
| Kohashi, M | 1 |
2 trials available for opc 12759 and Sjogren's Syndrome
| Article | Year |
|---|---|
Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes.
Topics: Adult; Aged; Aged, 80 and over; Alanine; CA-125 Antigen; Female; Gene Expression Regulation; Humans; | 2020 |
Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjögren's syndrome: a double-blind placebo-controlled multicenter trial.
Topics: Aged; Alanine; Anti-Inflammatory Agents; Double-Blind Method; Eating; Female; Humans; Male; Middle A | 2009 |
5 other studies available for opc 12759 and Sjogren's Syndrome
| Article | Year |
|---|---|
Immune modulation by rebamipide in a mouse model of Sjogren's syndrome via T and B cell regulation.
Topics: Alanine; Animals; B-Lymphocytes, Regulatory; Cytokines; Disease Models, Animal; Immunomodulation; Mi | 2019 |
Anti-inflammatory effects of rebamipide eyedrop administration on ocular lesions in a murine model of primary Sjögren's syndrome.
Topics: Administration, Ophthalmic; Alanine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Mod | 2014 |
Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in Sjögren syndrome patients with or without punctal occlusions.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antibodies, Antinuclear; Antioxidants; Autoantibodies; Eyel | 2014 |
Sjogren's syndrome: promising, new treatment options besides nizatidine.
Topics: Alanine; Antioxidants; Flax; Histamine H2 Antagonists; Humans; Nizatidine; Plant Preparations; Quino | 2009 |
Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome.
Topics: Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Autoantibodies; Cell Division; Cyt | 2008 |