opc 12759 has been researched along with Recrudescence in 8 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse." | 7.69 | Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. ( Arakawa, T; Fukuda, T; Kobayashi, K; Watanabe, T; Yamasaki, K, 1995) |
| "This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse." | 3.69 | Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. ( Arakawa, T; Fukuda, T; Kobayashi, K; Watanabe, T; Yamasaki, K, 1995) |
| "Oral aphthae count and pain scores were recorded daily in a diary by the patients themselves." | 2.71 | Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet's disease: a randomised, double-blind, placebo-controlled study. ( Hirohata, S; Inaba, G; Kogure, M; Matsuda, T; Miyanaga, Y; Mizushima, Y; Nakamura, S; Ohno, S; Tanaka, S; Ujihara, H, 2003) |
| "The ulcer recurrence rate was significantly lower in group OA and group OR than in group O." | 2.69 | Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status. ( Ando, K; Arakawa, T; Fujiwara, Y; Fukuda, T; Higuchi, K; Kobayashi, K; Kuroki, T; Nebiki, H; Takaishi, O; Uchida, T; Yamasaki, K, 1998) |
| "Mucosal inflammation is a crucial factor for the recurrence of peptic ulcer." | 1.33 | Rebamipide reduces recurrence of experimental gastric ulcers: role of free radicals and neutrophils. ( Osaka, T; Sakurai, K; Yamasaki, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, K | 1 |
| Furuta, K | 1 |
| Miwa, H | 1 |
| Oshima, T | 1 |
| Miki, M | 1 |
| Komazawa, Y | 1 |
| Iwakiri, K | 1 |
| Furuta, T | 1 |
| Koike, T | 1 |
| Shimatani, T | 1 |
| Kinoshita, Y | 1 |
| Matsuda, T | 1 |
| Ohno, S | 1 |
| Hirohata, S | 1 |
| Miyanaga, Y | 1 |
| Ujihara, H | 1 |
| Inaba, G | 1 |
| Nakamura, S | 1 |
| Tanaka, S | 1 |
| Kogure, M | 1 |
| Mizushima, Y | 1 |
| Sakurai, K | 1 |
| Osaka, T | 1 |
| Yamasaki, K | 4 |
| Fujiwara, Y | 2 |
| Higuchi, K | 2 |
| Tominaga, K | 1 |
| Watanabe, T | 2 |
| Arakawa, T | 4 |
| Fukuda, T | 2 |
| Kobayashi, K | 3 |
| Yoshikawa, T | 1 |
| Tarnawski, A | 1 |
| Nebiki, H | 1 |
| Uchida, T | 1 |
| Ando, K | 1 |
| Takaishi, O | 1 |
| Kuroki, T | 1 |
| Shiraki, M | 1 |
| Ishiyama, H | 1 |
| Kanbe, T | 1 |
| Yabuuchi, Y | 1 |
| Asada, S | 1 |
| Hirata, I | 1 |
| Ooshiba, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Topical Rebamipide Versus Topical Betamethasone for Management of Oral Ulcers in Behcet's Disease: A Randomized Clinical Trial[NCT06084624] | Phase 1/Phase 2 | 40 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for opc 12759 and Recrudescence
| Article | Year |
|---|---|
[Quality of ulcer healing and rebamipide].
Topics: Alanine; Amoxicillin; Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Drug Therapy, Combination | 2005 |
Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.
Topics: Alanine; Animals; Anti-Ulcer Agents; Clinical Trials as Topic; Disease Models, Animal; Gastric Mucos | 1998 |
3 trials available for opc 12759 and Recrudescence
| Article | Year |
|---|---|
A study on the efficacy of rebamipide for patients with proton pump inhibitor-refractory non-erosive reflux disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Alanine; Dose-Response Rela | 2012 |
Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet's disease: a randomised, double-blind, placebo-controlled study.
Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Behcet Syndrome; Double-Blind Method; Drug Therapy, Combina | 2003 |
Rebamipide prevents recurrence of gastric ulcers without affecting Helicobacter pylori status.
Topics: Aged; Alanine; Anti-Ulcer Agents; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male | 1998 |
3 other studies available for opc 12759 and Recrudescence
| Article | Year |
|---|---|
Rebamipide reduces recurrence of experimental gastric ulcers: role of free radicals and neutrophils.
Topics: Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Glutathione Peroxid | 2005 |
Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.
Topics: Acetates; Acetic Acid; Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Drug Therapy, Combination; M | 1995 |
[Healing promoting effect of proamipide, a novel drug that increases gastric defense mechanisms, on acetic acid-induced gastric ulcers in the rat].
Topics: Acetates; Alanine; Animals; Anti-Ulcer Agents; Fibrosis; Gastric Mucosa; Granulation Tissue; Male; Q | 1988 |