opc 12759 has been researched along with Osteoarthritis in 6 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, TJ | 1 |
| Kim, ER | 1 |
| Hong, SN | 1 |
| Kim, YH | 1 |
| Lee, YC | 1 |
| Kim, HS | 1 |
| Kim, K | 1 |
| Chang, DK | 1 |
| Izawa, T | 2 |
| Hutami, IR | 2 |
| Tanaka, E | 2 |
| Mori, H | 1 |
| Shinohara, T | 1 |
| Mino-Oka, A | 1 |
| Iwasa, A | 1 |
| Moon, SJ | 2 |
| Woo, YJ | 1 |
| Jeong, JH | 2 |
| Park, MK | 2 |
| Oh, HJ | 1 |
| Park, JS | 2 |
| Kim, EK | 2 |
| Cho, ML | 2 |
| Park, SH | 2 |
| Kim, HY | 2 |
| Min, JK | 2 |
| Hasegawa, M | 1 |
| Horiki, N | 1 |
| Tanaka, K | 1 |
| Wakabayashi, H | 1 |
| Tano, S | 1 |
| Katsurahara, M | 1 |
| Uchida, A | 1 |
| Takei, Y | 1 |
| Sudo, A | 1 |
| Yang, EJ | 1 |
1 review available for opc 12759 and Osteoarthritis
| Article | Year |
|---|---|
Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis.
Topics: Alanine; Animals; Antioxidants; Cartilage, Articular; Cell Differentiation; Homeostasis; Humans; Man | 2018 |
1 trial available for opc 12759 and Osteoarthritis
| Article | Year |
|---|---|
The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group.
Topics: Alanine; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; E | 2013 |
4 other studies available for opc 12759 and Osteoarthritis
| Article | Year |
|---|---|
Effectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies | 2019 |
Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.
Topics: Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Experimental | 2016 |
Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes.
Topics: Alanine; Analgesics; Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Cells, Cult | 2012 |
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis.
Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco | 2013 |