opc 12759 has been researched along with Mucositis in 5 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 7.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 3.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "Oral mucositis is a common adverse effect of chemotherapy that limits the required dose of chemotherapeutic agents." | 1.48 | Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. ( Asano, RT; Fujimoto, SI; Imano, M; Itoh, T; Matsuda, T; Nishida, S; Satou, T; Takeda, T; Tsubaki, M, 2018) |
| "Chemoradiotherapy for head and neck cancer is associated with a high incidence of severe oral mucositis; an adverse, painful event." | 1.37 | [Investigation of how to prevent mucositis induced by chemoradiotherapy]. ( Hushimi, C; Inoue, T; Kamata, S; Kobayashi, M; Masubuchi, T; Miura, K; Moya, M; Tada, Y; Tajima, H; Tosaka, C, 2011) |
| "Mucositis is one of the most frequent side effects induced by chemotherapy that damages the patients' QOL and response rate." | 1.37 | [The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy]. ( Fukuhara, K; Hayaishi, Y; Katsuragi, K; Kodama, S; Morisya, Y; Nakanishi, C; Terakura, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsubaki, M | 1 |
| Takeda, T | 1 |
| Asano, RT | 1 |
| Matsuda, T | 1 |
| Fujimoto, SI | 1 |
| Itoh, T | 1 |
| Imano, M | 1 |
| Satou, T | 1 |
| Nishida, S | 1 |
| Kim, HJ | 1 |
| Kim, JH | 1 |
| Moon, W | 1 |
| Park, J | 1 |
| Park, SJ | 1 |
| Song, GA | 1 |
| Han, SH | 1 |
| Lee, JH | 1 |
| Yasuda, T | 1 |
| Chiba, H | 1 |
| Satomi, T | 1 |
| Matsuo, A | 1 |
| Kaneko, T | 1 |
| Miyamatsu, H | 1 |
| Tosaka, C | 1 |
| Tajima, H | 1 |
| Inoue, T | 1 |
| Moya, M | 1 |
| Kobayashi, M | 1 |
| Miura, K | 1 |
| Tada, Y | 1 |
| Masubuchi, T | 1 |
| Hushimi, C | 1 |
| Kamata, S | 1 |
| Fukuhara, K | 1 |
| Terakura, M | 1 |
| Katsuragi, K | 1 |
| Kodama, S | 1 |
| Morisya, Y | 1 |
| Hayaishi, Y | 1 |
| Nakanishi, C | 1 |
1 trial available for opc 12759 and Mucositis
| Article | Year |
|---|---|
[A pilot study of rebamipide-gargle for chemoradiotherapy-induced mucositis in oral cancer patients].
Topics: Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Combined Modality Therapy; Female; Humans; | 2008 |
4 other studies available for opc 12759 and Mucositis
| Article | Year |
|---|---|
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Topics: Alanine; Animals; Antimetabolites; Antioxidants; Cell Death; Cell Survival; Fluorouracil; Gene Expre | 2018 |
Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
Topics: Alanine; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Apoptosis; Disease Models, Ani | 2015 |
[Investigation of how to prevent mucositis induced by chemoradiotherapy].
Topics: Alanine; Antineoplastic Agents; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; | 2011 |
[The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy].
Topics: Aged; Alanine; Antineoplastic Agents; Carnosine; Female; Humans; Male; Middle Aged; Mouthwashes; Muc | 2011 |