Page last updated: 2024-11-03

opc 12759 and Mucositis

opc 12759 has been researched along with Mucositis in 5 studies

rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase

Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines."7.81Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015)
"5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines."3.81Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015)
"Oral mucositis is a common adverse effect of chemotherapy that limits the required dose of chemotherapeutic agents."1.48Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. ( Asano, RT; Fujimoto, SI; Imano, M; Itoh, T; Matsuda, T; Nishida, S; Satou, T; Takeda, T; Tsubaki, M, 2018)
"Chemoradiotherapy for head and neck cancer is associated with a high incidence of severe oral mucositis; an adverse, painful event."1.37[Investigation of how to prevent mucositis induced by chemoradiotherapy]. ( Hushimi, C; Inoue, T; Kamata, S; Kobayashi, M; Masubuchi, T; Miura, K; Moya, M; Tada, Y; Tajima, H; Tosaka, C, 2011)
"Mucositis is one of the most frequent side effects induced by chemotherapy that damages the patients' QOL and response rate."1.37[The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy]. ( Fukuhara, K; Hayaishi, Y; Katsuragi, K; Kodama, S; Morisya, Y; Nakanishi, C; Terakura, M, 2011)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tsubaki, M1
Takeda, T1
Asano, RT1
Matsuda, T1
Fujimoto, SI1
Itoh, T1
Imano, M1
Satou, T1
Nishida, S1
Kim, HJ1
Kim, JH1
Moon, W1
Park, J1
Park, SJ1
Song, GA1
Han, SH1
Lee, JH1
Yasuda, T1
Chiba, H1
Satomi, T1
Matsuo, A1
Kaneko, T1
Miyamatsu, H1
Tosaka, C1
Tajima, H1
Inoue, T1
Moya, M1
Kobayashi, M1
Miura, K1
Tada, Y1
Masubuchi, T1
Hushimi, C1
Kamata, S1
Fukuhara, K1
Terakura, M1
Katsuragi, K1
Kodama, S1
Morisya, Y1
Hayaishi, Y1
Nakanishi, C1

Trials

1 trial available for opc 12759 and Mucositis

ArticleYear
[A pilot study of rebamipide-gargle for chemoradiotherapy-induced mucositis in oral cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:7

    Topics: Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Combined Modality Therapy; Female; Humans;

2008

Other Studies

4 other studies available for opc 12759 and Mucositis

ArticleYear
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
    Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 46

    Topics: Alanine; Animals; Antimetabolites; Antioxidants; Cell Death; Cell Survival; Fluorouracil; Gene Expre

2018
Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:2

    Topics: Alanine; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Apoptosis; Disease Models, Ani

2015
[Investigation of how to prevent mucositis induced by chemoradiotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:10

    Topics: Alanine; Antineoplastic Agents; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans;

2011
[The effects of Rebamipide and Polaprezinc mouthwash and uptake on mucositis induced by chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:13

    Topics: Aged; Alanine; Antineoplastic Agents; Carnosine; Female; Humans; Male; Middle Aged; Mouthwashes; Muc

2011