opc 12759 has been researched along with Intestinal Diseases in 9 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly-used medications, and ailments such as arthritis or heart disease, require long-term use of these drugs, which can induce gastroenteropathy with bleeding and ulcers." | 3.11 | The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study. ( Choi, YJ; Ha, YJ; Kang, EH; Kim, HS; Kim, KJ; Kim, N; Lee, DH; Lee, YJ; Liu, F; Oh, DJ; Park, YS; Shin, CM; Yoon, H, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Oh, DJ | 1 |
| Yoon, H | 1 |
| Kim, HS | 1 |
| Choi, YJ | 1 |
| Shin, CM | 1 |
| Park, YS | 1 |
| Kim, N | 2 |
| Lee, DH | 1 |
| Ha, YJ | 1 |
| Kang, EH | 1 |
| Lee, YJ | 1 |
| Kim, KJ | 1 |
| Liu, F | 1 |
| Xu, N | 1 |
| Zhang, C | 1 |
| Jing, L | 1 |
| Mou, S | 1 |
| Cao, X | 1 |
| Yu, Z | 1 |
| Kurokawa, S | 1 |
| Katsuki, S | 1 |
| Fujita, T | 1 |
| Saitoh, Y | 1 |
| Ohta, H | 1 |
| Nishikawa, K | 1 |
| Sato, Y | 2 |
| Ohira, K | 1 |
| Yamada, M | 1 |
| Kato, M | 1 |
| Satoh, H | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 2 |
| Watanabe, T | 2 |
| Takeuchi, T | 1 |
| Handa, O | 1 |
| Sakata, Y | 1 |
| Tanigawa, T | 2 |
| Shiba, M | 2 |
| Naito, Y | 1 |
| Higuchi, K | 1 |
| Fujimoto, K | 1 |
| Yoshikawa, T | 1 |
| Arakawa, T | 2 |
| Otani, K | 1 |
| Shimada, S | 1 |
| Nadatani, Y | 1 |
| Nagami, Y | 1 |
| Tanaka, F | 1 |
| Kamata, N | 1 |
| Yamagami, H | 1 |
| Tominaga, K | 1 |
| Fujiwara, Y | 1 |
| Mizukami, K | 1 |
| Murakami, K | 1 |
| Abe, T | 1 |
| Inoue, K | 1 |
| Uchida, M | 1 |
| Okimoto, T | 1 |
| Kodama, M | 1 |
| Fujioka, T | 1 |
| Niwa, Y | 1 |
| Nakamura, M | 1 |
| Ohmiya, N | 1 |
| Maeda, O | 1 |
| Ando, T | 1 |
| Itoh, A | 1 |
| Hirooka, Y | 1 |
| Goto, H | 1 |
| Mizoguchi, H | 1 |
| Ogawa, Y | 1 |
| Kanatsu, K | 1 |
| Tanaka, A | 1 |
| Kato, S | 1 |
1 review available for opc 12759 and Intestinal Diseases
| Article | Year |
|---|---|
Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage.
Topics: Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Gastrointestinal Microbiome; Hu | 2017 |
5 trials available for opc 12759 and Intestinal Diseases
| Article | Year |
|---|---|
The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study.
Topics: Alanine; Anti-Inflammatory Agents, Non-Steroidal; Humans; Intestinal Diseases; Pilot Projects; Ulcer | 2022 |
A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury.
Topics: Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscop | 2014 |
A multicenter, randomized, double-blind, placebo-controlled trial of high-dose rebamipide treatment for low-dose aspirin-induced moderate-to-severe small intestinal damage.
Topics: Aged; Alanine; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Dose-Response Relationship, Drug; Doub | 2015 |
Aspirin-induced small bowel injuries and the preventive effect of rebamipide.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule E | 2011 |
Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective, randomized, double-blinded, placebo-controlled, cross-over study.
Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsule Endoscopy; Cross | 2008 |
3 other studies available for opc 12759 and Intestinal Diseases
| Article | Year |
|---|---|
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Claudin-1; Cytokines; Diclofenac; Disease | 2021 |
Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dose-Respo | 2014 |
Protective effect of rebamipide on indomethacin-induced intestinal damage in rats.
Topics: Alanine; Ampicillin; Animals; Anti-Ulcer Agents; Bacterial Translocation; Catalase; Dose-Response Re | 2001 |