opc 12759 has been researched along with Hematochezia in 10 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Hematochezia: The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coronary artery disease and co-use of thienopyridine were associated with SBB in NSAIDs users." | 3.81 | Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users. ( Cho, KM; Choi, SK; Chung, JO; Jun, CH; Kim, BS; Kim, HS; Kim, TJ; Park, CH; Park, SY; Rew, JS; Son, DJ, 2015) |
| " The grade of gastric mucosal injuries was evaluated by esophagogastroduodenoscopy before and after dosing (on day 0 and day 14), and the grade of gastric mucosal injury was assessed according to the modified Lanza score." | 2.79 | A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel. ( Fukui, H; Hida, N; Hori, K; Miwa, H; Nakamura, S; Ogawa, T; Ohda, Y; Okugawa, T; Oshima, T; Tomita, T; Tozawa, K; Watari, J, 2014) |
| "Pretreatment with omeprazole (30 mg/kg s." | 1.30 | Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. ( Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, TJ | 2 |
| Kim, ER | 1 |
| Hong, SN | 1 |
| Kim, YH | 1 |
| Lee, YC | 1 |
| Kim, HS | 2 |
| Kim, K | 1 |
| Chang, DK | 1 |
| Nagai, N | 1 |
| Sakamoto, R | 1 |
| Yamamoto, S | 1 |
| Deguchi, S | 1 |
| Otake, H | 1 |
| Tanino, T | 1 |
| Tozawa, K | 1 |
| Oshima, T | 1 |
| Okugawa, T | 1 |
| Ogawa, T | 1 |
| Ohda, Y | 1 |
| Tomita, T | 1 |
| Hida, N | 1 |
| Fukui, H | 1 |
| Hori, K | 1 |
| Watari, J | 1 |
| Nakamura, S | 1 |
| Miwa, H | 1 |
| Sugimoto, M | 1 |
| Uotani, T | 1 |
| Furuta, T | 1 |
| Takeuchi, K | 1 |
| Takayama, S | 1 |
| Hashimoto, E | 1 |
| Itayama, M | 1 |
| Amagase, K | 1 |
| Izuhara, C | 1 |
| Cho, KM | 1 |
| Park, SY | 1 |
| Chung, JO | 1 |
| Jun, CH | 1 |
| Son, DJ | 1 |
| Kim, BS | 1 |
| Park, CH | 1 |
| Choi, SK | 1 |
| Rew, JS | 1 |
| Niwa, Y | 1 |
| Nakamura, M | 1 |
| Omiya, N | 1 |
| Itoh, A | 1 |
| Hirooka, Y | 1 |
| Goto, H | 1 |
| Sakurai, K | 1 |
| Yamasaki, K | 2 |
| Huh, K | 1 |
| Kwon, TH | 1 |
| Kim, SK | 1 |
| Kim, JS | 1 |
| Shin, US | 1 |
| Arakawa, T | 1 |
| Takaishi, O | 1 |
| Higuchi, K | 1 |
| Kobayashi, K | 1 |
| Kuroki, T | 1 |
1 trial available for opc 12759 and Hematochezia
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.
Topics: Adult; Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Double-Blind Method; Gastric Mucosa; Gastro | 2014 |
9 other studies available for opc 12759 and Hematochezia
| Article | Year |
|---|---|
Effectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies | 2019 |
Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Indomethacin | 2019 |
Does rebamipide prevent gastric mucosal injury in patients taking aspirin and clopidogrel?
Topics: Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Platele | 2014 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users.
Topics: Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsule Endoscopy; Corona | 2015 |
Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
Topics: Adenocarcinoma; Adenoma; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Capsule Endoscopy; Colonic N | 2007 |
Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach.
Topics: Alanine; Animals; Gastric Mucosa; Gastrointestinal Hemorrhage; Glutathione; Glutathione Peroxidase; | 1994 |
Therapeutic effect of rebamipide on ammonia-induced gastric mucosal hemorrhagic lesion in rats.
Topics: Alanine; Ammonia; Animals; Anti-Ulcer Agents; Enzyme Inhibitors; Gastric Mucosa; Gastrointestinal He | 1998 |
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalas | 1999 |