opc 12759 has been researched along with Gastrointestinal Hemorrhage in 10 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coronary artery disease and co-use of thienopyridine were associated with SBB in NSAIDs users." | 3.81 | Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users. ( Cho, KM; Choi, SK; Chung, JO; Jun, CH; Kim, BS; Kim, HS; Kim, TJ; Park, CH; Park, SY; Rew, JS; Son, DJ, 2015) |
| " The grade of gastric mucosal injuries was evaluated by esophagogastroduodenoscopy before and after dosing (on day 0 and day 14), and the grade of gastric mucosal injury was assessed according to the modified Lanza score." | 2.79 | A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel. ( Fukui, H; Hida, N; Hori, K; Miwa, H; Nakamura, S; Ogawa, T; Ohda, Y; Okugawa, T; Oshima, T; Tomita, T; Tozawa, K; Watari, J, 2014) |
| "Pretreatment with omeprazole (30 mg/kg s." | 1.30 | Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. ( Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, TJ | 2 |
| Kim, ER | 1 |
| Hong, SN | 1 |
| Kim, YH | 1 |
| Lee, YC | 1 |
| Kim, HS | 2 |
| Kim, K | 1 |
| Chang, DK | 1 |
| Nagai, N | 1 |
| Sakamoto, R | 1 |
| Yamamoto, S | 1 |
| Deguchi, S | 1 |
| Otake, H | 1 |
| Tanino, T | 1 |
| Tozawa, K | 1 |
| Oshima, T | 1 |
| Okugawa, T | 1 |
| Ogawa, T | 1 |
| Ohda, Y | 1 |
| Tomita, T | 1 |
| Hida, N | 1 |
| Fukui, H | 1 |
| Hori, K | 1 |
| Watari, J | 1 |
| Nakamura, S | 1 |
| Miwa, H | 1 |
| Sugimoto, M | 1 |
| Uotani, T | 1 |
| Furuta, T | 1 |
| Takeuchi, K | 1 |
| Takayama, S | 1 |
| Hashimoto, E | 1 |
| Itayama, M | 1 |
| Amagase, K | 1 |
| Izuhara, C | 1 |
| Cho, KM | 1 |
| Park, SY | 1 |
| Chung, JO | 1 |
| Jun, CH | 1 |
| Son, DJ | 1 |
| Kim, BS | 1 |
| Park, CH | 1 |
| Choi, SK | 1 |
| Rew, JS | 1 |
| Niwa, Y | 1 |
| Nakamura, M | 1 |
| Omiya, N | 1 |
| Itoh, A | 1 |
| Hirooka, Y | 1 |
| Goto, H | 1 |
| Sakurai, K | 1 |
| Yamasaki, K | 2 |
| Huh, K | 1 |
| Kwon, TH | 1 |
| Kim, SK | 1 |
| Kim, JS | 1 |
| Shin, US | 1 |
| Arakawa, T | 1 |
| Takaishi, O | 1 |
| Higuchi, K | 1 |
| Kobayashi, K | 1 |
| Kuroki, T | 1 |
1 trial available for opc 12759 and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.
Topics: Adult; Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Double-Blind Method; Gastric Mucosa; Gastro | 2014 |
9 other studies available for opc 12759 and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Effectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies | 2019 |
Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Indomethacin | 2019 |
Does rebamipide prevent gastric mucosal injury in patients taking aspirin and clopidogrel?
Topics: Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Platele | 2014 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users.
Topics: Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Capsule Endoscopy; Corona | 2015 |
Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
Topics: Adenocarcinoma; Adenoma; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Capsule Endoscopy; Colonic N | 2007 |
Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach.
Topics: Alanine; Animals; Gastric Mucosa; Gastrointestinal Hemorrhage; Glutathione; Glutathione Peroxidase; | 1994 |
Therapeutic effect of rebamipide on ammonia-induced gastric mucosal hemorrhagic lesion in rats.
Topics: Alanine; Ammonia; Animals; Anti-Ulcer Agents; Enzyme Inhibitors; Gastric Mucosa; Gastrointestinal He | 1998 |
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalas | 1999 |