opc 12759 has been researched along with Disease Models, Animal in 53 studies
rebamipide: structure in first source; RN refers to (+-)-isomer; inhibits gastric xanthine oxidase
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 7.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 3.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers." | 3.79 | The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide. ( Choi, HS; Chun, HJ; Jeen, YT; Keum, B; Kim, CD; Kim, ES; Lee, HS; Lee, M; Lim, JY; Ryu, HS; Seo, YS; Sul, D; Um, SH, 2013) |
| " pylori, especially after MNU administration to promote carcinogenesis and the effects of the long-term administration of rebamipide or nimesulide were evaluated." | 2.42 | Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? ( Cho, SW; Hahm, KB; Han, SU; Kim, DY; Kim, JH; Kim, MW; Kim, YB; Lee, JS; Nahm, KT; Oh, TY; Song, YJ; Surh, YJ; Yoo, BM, 2003) |
| "Rebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to highly diminutive bioavailability (<10%)." | 1.62 | Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies. ( Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S, 2021) |
| "Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation." | 1.48 | Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice. ( Jang, H; Jang, WS; Jin, YW; Kim, H; Lee, C; Lee, J; Lee, SJ; Lee, SS; Myung, H; Myung, JK; Park, S; Shim, S, 2018) |
| "Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups." | 1.48 | Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease. ( Choi, YK; Chung, JW; Gweon, TG; Kim, BW; Kim, CW; Kim, HG; Kim, JS; Park, JH; Park, SM, 2018) |
| "Irsogladine maleate (IM) is a drug with gastric mucosal protective properties." | 1.48 | [Development of "Patient Friendly Formulations" to Counter the Side Effects of Cancer Chemotherapy]. ( Hanawa, T; Kawano, Y; Satoh, M, 2018) |
| "To determine the mucinogenic effect of dry eye (DE) treatment drugs currently in use, we compared the levels of mucin production and inflammatory cytokine expression on the ocular surfaces using a DE-induced mice model." | 1.48 | Comparison of Ocular Surface Mucin Expression After Topical Ophthalmic Drug Administration in Dry Eye-Induced Mouse Model. ( Ji, YW; Kang, HG; Kim, HC; Lee, HK; Moon, I; Noh, H; Song, JS; Yeo, A, 2018) |
| "MNNG-induced carcinogenesis and may also inhibit progression of cancer in rats." | 1.42 | Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. ( Ebi, M; Hayashi, N; Joh, T; Katano, T; Kataoka, H; Mizoshita, T; Mori, Y; Ozeki, K; Shimura, T; Tanida, S; Tatematsu, M; Tsukamoto, H; Tsukamoto, T, 2015) |
| "A rat model of dry eye was developed by surgical removal of exorbital lacrimal glands." | 1.39 | Protection of human corneal epithelial cells from TNF-α-induced disruption of barrier function by rebamipide. ( Haruta, J; Kimura, K; Morita, Y; Orita, T; Sonoda, KH; Takeji, Y, 2013) |
| "The present study evaluated the therapeutic effects of rebamipide alone and in combination with cimetidine on experimental gastritis established by the administration of 5 mM sodium taurocholate (TCA) for 6 months in rats." | 1.28 | Therapeutic effects of oral rebamipide and in combination with cimetidine on experimental gastritis in rats. ( Fujimura, J; Haruma, K; Kajiyama, G; Kishimoto, S; Kobayashi, H; Machino, H; Sakurai, K; Shimamoto, T; Shimizu, S; Yamasaki, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (13.21) | 18.2507 |
| 2000's | 10 (18.87) | 29.6817 |
| 2010's | 30 (56.60) | 24.3611 |
| 2020's | 6 (11.32) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, Q | 1 |
| Wu, X | 1 |
| Xin, M | 1 |
| Jindal, A | 1 |
| Singh, R | 1 |
| Tomar, S | 1 |
| Dureja, J | 1 |
| Karan, M | 1 |
| Chadha, R | 1 |
| Jin-Sil, P | 1 |
| Sun-Hee, H | 1 |
| SeungCheon, Y | 1 |
| JeongWon, C | 1 |
| Kyung-Ah, J | 1 |
| Mi-La, C | 1 |
| Sung-Hwan, P | 1 |
| Shamloo, K | 1 |
| Barbarino, A | 1 |
| Alfuraih, S | 1 |
| Sharma, A | 1 |
| Tanaka, H | 1 |
| Nakayama, T | 1 |
| Tsukamoto, M | 1 |
| Watanabe, A | 1 |
| Nakamura, T | 1 |
| Yokoi, N | 2 |
| Sotozono, C | 2 |
| Kinoshita, S | 2 |
| Abdel-Wahab, BA | 1 |
| Ali, FEM | 1 |
| Alkahtani, SA | 1 |
| Alshabi, AM | 1 |
| Mahnashi, MH | 1 |
| Hassanein, EHM | 1 |
| Xu, N | 1 |
| Zhang, C | 1 |
| Jing, L | 1 |
| Mou, S | 1 |
| Cao, X | 1 |
| Yu, Z | 1 |
| Jang, H | 1 |
| Park, S | 1 |
| Lee, J | 1 |
| Myung, JK | 1 |
| Jang, WS | 1 |
| Lee, SJ | 1 |
| Myung, H | 1 |
| Lee, C | 1 |
| Kim, H | 1 |
| Lee, SS | 1 |
| Jin, YW | 1 |
| Shim, S | 1 |
| Gweon, TG | 1 |
| Park, JH | 1 |
| Kim, BW | 1 |
| Choi, YK | 1 |
| Kim, JS | 1 |
| Park, SM | 1 |
| Kim, CW | 1 |
| Kim, HG | 1 |
| Chung, JW | 1 |
| Hanawa, T | 1 |
| Kawano, Y | 1 |
| Satoh, M | 1 |
| Kojima, T | 3 |
| Simsek, C | 2 |
| Igarashi, A | 2 |
| Aoki, K | 1 |
| Higa, K | 1 |
| Shimizu, T | 2 |
| Dogru, M | 2 |
| Tsubota, K | 3 |
| Shimazaki, J | 3 |
| Moon, I | 1 |
| Kang, HG | 1 |
| Yeo, A | 1 |
| Noh, H | 1 |
| Kim, HC | 1 |
| Song, JS | 1 |
| Ji, YW | 1 |
| Lee, HK | 1 |
| Ogawa, M | 1 |
| Nagata, T | 2 |
| Kawakita, T | 2 |
| Fu, R | 1 |
| Jiang, Y | 1 |
| Zhou, J | 1 |
| Zhang, J | 1 |
| Fujimoto, A | 1 |
| Uraoka, T | 1 |
| Yahagi, N | 1 |
| Kimura, K | 1 |
| Morita, Y | 1 |
| Orita, T | 1 |
| Haruta, J | 1 |
| Takeji, Y | 1 |
| Sonoda, KH | 1 |
| Ueta, M | 1 |
| Choi, HS | 1 |
| Lim, JY | 1 |
| Chun, HJ | 1 |
| Lee, M | 1 |
| Kim, ES | 1 |
| Keum, B | 1 |
| Seo, YS | 1 |
| Jeen, YT | 1 |
| Um, SH | 1 |
| Lee, HS | 1 |
| Kim, CD | 2 |
| Ryu, HS | 1 |
| Sul, D | 1 |
| Ohguchi, T | 1 |
| Ibrahim, OM | 1 |
| Shirasawa, T | 1 |
| Satake, Y | 1 |
| Ishida, S | 1 |
| Funahashi, Y | 2 |
| Yoshida, M | 2 |
| Yamamoto, T | 2 |
| Majima, T | 2 |
| Takai, S | 2 |
| Gotoh, M | 2 |
| Nakashima, T | 3 |
| Sako, N | 1 |
| Matsuda, T | 1 |
| Uematsu, N | 2 |
| Sakurai, K | 4 |
| Ishida, T | 1 |
| Arakaki, R | 2 |
| Eguchi, H | 1 |
| Yamada, A | 1 |
| Kudo, Y | 1 |
| Iwasa, A | 1 |
| Enkhmaa, T | 1 |
| Hotta, F | 1 |
| Mitamura-Aizawa, S | 1 |
| Mitamura, Y | 1 |
| Hayashi, Y | 2 |
| Ishimaru, N | 2 |
| Takeuchi, K | 2 |
| Takayama, S | 1 |
| Hashimoto, E | 1 |
| Itayama, M | 1 |
| Amagase, K | 1 |
| Izuhara, C | 1 |
| Tsukamoto, H | 1 |
| Mizoshita, T | 1 |
| Katano, T | 1 |
| Hayashi, N | 1 |
| Ozeki, K | 1 |
| Ebi, M | 1 |
| Shimura, T | 1 |
| Mori, Y | 1 |
| Tanida, S | 1 |
| Kataoka, H | 1 |
| Tsukamoto, T | 1 |
| Tatematsu, M | 1 |
| Joh, T | 1 |
| Kim, HJ | 1 |
| Kim, JH | 2 |
| Moon, W | 1 |
| Park, J | 1 |
| Park, SJ | 1 |
| Song, GA | 1 |
| Han, SH | 1 |
| Lee, JH | 1 |
| Zhao, Y | 1 |
| Xu, X | 1 |
| Ma, W | 1 |
| Gao, P | 1 |
| Wang, Y | 1 |
| Liang, K | 1 |
| Li, R | 1 |
| Kohata, Y | 1 |
| Nakahara, K | 1 |
| Tanigawa, T | 1 |
| Yamagami, H | 1 |
| Shiba, M | 1 |
| Watanabe, T | 1 |
| Tominaga, K | 1 |
| Fujiwara, Y | 1 |
| Arakawa, T | 3 |
| Shibamori, M | 1 |
| Sato, M | 1 |
| Sato, A | 1 |
| Yamamura, Y | 1 |
| Sasabe, H | 1 |
| Umehara, K | 1 |
| Murakami, I | 1 |
| Zhang, R | 1 |
| Kubo, M | 1 |
| Nagaoka, K | 1 |
| Eguchi, E | 1 |
| Ogino, K | 1 |
| Zakaria, S | 1 |
| El-Sisi, A | 1 |
| Abe, N | 1 |
| Funato, H | 1 |
| Hirata, A | 1 |
| Nakai, M | 1 |
| Iizuka, M | 1 |
| Shiraishi, H | 1 |
| Jobu, K | 1 |
| Yagi, Y | 1 |
| Kadota, A | 1 |
| Ogi, K | 1 |
| Yokota, J | 1 |
| Miyamura, M | 1 |
| Nagai, N | 1 |
| Ito, Y | 1 |
| Okamoto, N | 1 |
| Shimomura, Y | 1 |
| Gohil, P | 1 |
| Thakkar, H | 1 |
| Gohil, U | 1 |
| Deshpande, S | 1 |
| Imaeda, H | 1 |
| Fujimoto, T | 1 |
| Takahashi, K | 1 |
| Kasumi, E | 1 |
| Fujiyama, Y | 1 |
| Andoh, A | 1 |
| Hahm, KB | 1 |
| Song, YJ | 1 |
| Oh, TY | 1 |
| Lee, JS | 1 |
| Surh, YJ | 1 |
| Kim, YB | 1 |
| Yoo, BM | 1 |
| Han, SU | 1 |
| Nahm, KT | 1 |
| Kim, MW | 1 |
| Kim, DY | 1 |
| Cho, SW | 1 |
| Okayama, M | 1 |
| Tsubouchi, R | 1 |
| Nishio, H | 1 |
| Kato, S | 1 |
| Hiratsuka, T | 1 |
| Futagami, S | 1 |
| Tatsuguchi, A | 1 |
| Suzuki, K | 1 |
| Shinji, Y | 1 |
| Kusunoki, M | 1 |
| Shinoki, K | 1 |
| Nishigaki, H | 1 |
| Fujimori, S | 1 |
| Wada, K | 1 |
| Miyake, K | 1 |
| Gudis, K | 1 |
| Tsukui, T | 1 |
| Sakamoto, C | 1 |
| Nakamura, M | 1 |
| Takahashi, T | 2 |
| Matsumoto, T | 1 |
| Atsuda, K | 1 |
| Hibi, N | 1 |
| Matsui, H | 1 |
| Yamada, H | 1 |
| Tsuchimoto, K | 1 |
| Maeda, T | 1 |
| Nagamoto, H | 1 |
| Kumakura, T | 1 |
| Takai, M | 1 |
| Mori, T | 1 |
| Laharie, D | 1 |
| Ménard, S | 1 |
| Asencio, C | 1 |
| Vidal-Martinez, T | 1 |
| Rullier, A | 1 |
| Zerbib, F | 1 |
| Candalh, C | 1 |
| Mégraud, F | 2 |
| Heyman, M | 2 |
| Matysiak-Budnik, T | 2 |
| Kohashi, M | 1 |
| Takeuchi, Y | 1 |
| Takahashi, M | 1 |
| Fuchikami, J | 1 |
| Zea-Iriarte, WL | 1 |
| Makiyama, K | 1 |
| Goto, S | 1 |
| Murase, K | 1 |
| Urata, Y | 1 |
| Sekine, I | 1 |
| Hara, K | 1 |
| Kondo, T | 1 |
| Watanabe, S | 1 |
| Wang, XE | 1 |
| Hirose, M | 1 |
| Yoshizawa, T | 1 |
| Iwazaki, R | 1 |
| Oide, H | 1 |
| Kitamura, T | 1 |
| Miwa, H | 1 |
| Miyazaki, A | 1 |
| Sato, N | 1 |
| Kobayashi, K | 2 |
| Yoshikawa, T | 1 |
| Tarnawski, A | 2 |
| Hong, KW | 1 |
| Kim, KE | 1 |
| Rhim, BY | 1 |
| Lee, WS | 1 |
| Yamane, T | 1 |
| Nakatani, H | 1 |
| Matsumoto, H | 1 |
| Iwata, Y | 1 |
| Kikuoka, N | 1 |
| de Mascarel, A | 1 |
| Abely, M | 1 |
| Mayo, K | 1 |
| Kishimoto, S | 2 |
| Haruma, K | 2 |
| Tari, A | 1 |
| Nakano, M | 1 |
| Nakagawa, Y | 1 |
| Fujimura, J | 1 |
| Machino, H | 1 |
| Shimamoto, T | 1 |
| Kobayashi, H | 1 |
| Shimizu, S | 1 |
| Kajiyama, G | 1 |
| Yamasaki, K | 1 |
2 reviews available for opc 12759 and Disease Models, Animal
| Article | Year |
|---|---|
Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?
Topics: Alanine; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyto | 2003 |
Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.
Topics: Alanine; Animals; Anti-Ulcer Agents; Clinical Trials as Topic; Disease Models, Animal; Gastric Mucos | 1998 |
51 other studies available for opc 12759 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway.
Topics: Alanine; Animals; Antioxidants; Blotting, Western; Burns, Chemical; Chickens; Chorioallantoic Membra | 2021 |
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; C | 2021 |
Immune modulation by rebamipide in a mouse model of Sjogren's syndrome via T and B cell regulation.
Topics: Alanine; Animals; B-Lymphocytes, Regulatory; Cytokines; Disease Models, Animal; Immunomodulation; Mi | 2019 |
Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue.
Topics: Administration, Ophthalmic; Alanine; Animals; Antioxidants; Bone Marrow Transplantation; CA-125 Anti | 2019 |
Rebamipide promotes lacrimal duct epithelial cell survival via protecting barrier function.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Electri | 2020 |
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; | 2020 |
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Claudin-1; Cytokines; Diclofenac; Disease | 2021 |
Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cell Differentiation; Cell Proliferation; Colitis; Colon; Disea | 2018 |
Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Alanine; Animals; Anti-Ulcer Agents; Disease Models, Animal | 2018 |
[Development of "Patient Friendly Formulations" to Counter the Side Effects of Cancer Chemotherapy].
Topics: Administration, Oral; Alanine; Animals; Antineoplastic Agents; Cell Communication; Cyclic AMP; Disea | 2018 |
The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 (Sod1) Knockout Mice.
Topics: Alanine; Animals; Antioxidants; Biomarkers; Cell Differentiation; Conjunctiva; Disease Models, Anima | 2018 |
Comparison of Ocular Surface Mucin Expression After Topical Ophthalmic Drug Administration in Dry Eye-Induced Mouse Model.
Topics: Administration, Topical; Alanine; Animals; Anti-Inflammatory Agents; Cyclosporine; Disease Models, A | 2018 |
The Effect of Rebamipide Ophthalmic Solution on Cytokine and Mucin Secretion in Culture of Conjunctival Epithelial Cells From the Cu, Zn-Superoxide Dismutase-1 (SOD-1) Knock-Down Mouse.
Topics: Alanine; Animals; Antioxidants; Cells, Cultured; Conjunctiva; Conjunctival Diseases; Copper; Cytokin | 2019 |
Rebamipide ophthalmic solution modulates the ratio of T helper cell 17/regulatory T cells in dry eye disease mice.
Topics: Alanine; Animals; Conjunctiva; Cornea; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Female; | 2019 |
Rebamipide solution as a submucosal injection material for possible prevention of gastric stenosis after endoscopic submucosal dissection.
Topics: Alanine; Animals; Anti-Ulcer Agents; Disease Models, Animal; Endoscopic Mucosal Resection; Gastric M | 2019 |
Protection of human corneal epithelial cells from TNF-α-induced disruption of barrier function by rebamipide.
Topics: Adherens Junctions; Alanine; Animals; Antioxidants; beta Catenin; Cadherins; Cell Line; Disease Mode | 2013 |
Rebamipide suppresses PolyI:C-stimulated cytokine production in human conjunctival epithelial cells.
Topics: Alanine; Animals; Antioxidants; Conjunctiva; Conjunctivitis, Allergic; Cytokines; Disease Models, An | 2013 |
The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carnosin | 2013 |
The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice.
Topics: Alanine; Animals; Conjunctiva; Disease Models, Animal; Dose-Response Relationship, Drug; Dry Eye Syn | 2013 |
Intravesical application of rebamipide suppresses bladder inflammation in a rat cystitis model.
Topics: Administration, Intravesical; Alanine; Animals; Cystitis; Disease Models, Animal; Female; Quinolones | 2014 |
Novel submicronized rebamipide liquid with moderate viscosity: significant effects on oral mucositis in animal models.
Topics: Administration, Oral; Alanine; Animals; Anti-Ulcer Agents; Cautery; Disease Models, Animal; Drug Car | 2014 |
Anti-inflammatory effects of rebamipide eyedrop administration on ocular lesions in a murine model of primary Sjögren's syndrome.
Topics: Administration, Ophthalmic; Alanine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Mod | 2014 |
Intravesical application of rebamipide promotes urothelial healing in a rat cystitis model.
Topics: Administration, Intravesical; Alanine; Animals; Cystitis; Disease Models, Animal; Female; Quinolones | 2014 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
Topics: Adenocarcinoma; Alanine; Animals; Antioxidants; Carcinogenesis; Carcinogens; Disease Models, Animal; | 2015 |
Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
Topics: Alanine; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Apoptosis; Disease Models, Ani | 2015 |
Rebamipide suppresses TNF-α mediated inflammation in vitro and attenuates the severity of dermatitis in mice.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Transformed; Dermatitis, Aller | 2015 |
Rebamipide Alters the Esophageal Microbiome and Reduces the Incidence of Barrett's Esophagus in a Rat Model.
Topics: Alanine; Animals; Anti-Ulcer Agents; Barrett Esophagus; Clostridium; Disease Models, Animal; Enteroc | 2015 |
Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice.
Topics: Alanine; Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Squamous Cell; Cell Line, Tumor; C | 2015 |
Rebamipide suppresses mite-induced asthmatic responses in NC/Nga mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine; Allergens; Animals; Antigens, Dermatophagoides; Antioxidants; | 2015 |
Rebamipide retards CCl4-induced hepatic fibrosis in rats: Possible role for PGE2.
Topics: Alanine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbo | 2016 |
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal | 2016 |
Size effect of rebamipide ophthalmic nanodispersions on its therapeutic efficacy for corneal wound healing.
Topics: Alanine; Animals; Antioxidants; Cell Line; Corneal Injuries; Disease Models, Animal; Epithelium, Cor | 2016 |
Preliminary studies on the effect of rebamipide against the trypsin and egg-albumin induced experimental model of asthma.
Topics: Alanine; Animals; Asthma; Disease Models, Animal; Female; Histamine Release; Male; Mice; Ovalbumin; | 2011 |
Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice.
Topics: Alanine; Animals; Cecum; Disease Models, Animal; DNA, Bacterial; Drug Therapy, Combination; Female; | 2012 |
Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced rat colitis.
Topics: Administration, Rectal; Alanine; Animals; Anti-Ulcer Agents; Anticoagulants; Colitis; Dextran Sulfat | 2004 |
COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice.
Topics: Alanine; Animals; Blotting, Western; Celiac Artery; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygena | 2005 |
Direct autoradiographic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis in rats.
Topics: Administration, Oral; Alanine; Animals; Anti-Ulcer Agents; Colitis; Dextran Sulfate; Disease Models, | 2005 |
Rebamipide enema is effective for treatment of experimental dextran sulfate sodium induced colitis in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Colitis, Ulcerative; D | 2005 |
Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice.
Topics: Alanine; Animals; Anti-Ulcer Agents; Colon; Disease Models, Animal; Female; Flow Cytometry; Helicoba | 2007 |
Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome.
Topics: Administration, Oral; Alanine; Animals; Anti-Inflammatory Agents; Autoantibodies; Cell Division; Cyt | 2008 |
Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke.
Topics: Alanine; Animals; Anti-Ulcer Agents; Blood Gas Analysis; Dinoprostone; Disease Models, Animal; Gastr | 2008 |
Impairment of antioxidants in colonic epithelial cells isolated from trinitrobenzene sulphonic acid-induced colitis rats. Protective effect of rebamipide.
Topics: Alanine; Analysis of Variance; Animals; Anti-Ulcer Agents; Antioxidants; Colitis; Culture Techniques | 1996 |
Effects of rebamipide on bile acid-induced inhibition of gastric epithelial repair in a rabbit cell culture model.
Topics: Actins; Alanine; Animals; Anti-Ulcer Agents; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, | 1996 |
Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action?
Topics: Alanine; Animals; Anti-Ulcer Agents; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors | 1998 |
Effect of rebamipide on liver damage and increased tumor necrosis factor in a rat model of endotoxin shock.
Topics: Alanine; Animals; Disease Models, Animal; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; | 1998 |
Inhibitory effects of rebamipide on ENNG-induced duodenal carcinogenesis in mice: a possible strategy for chemoprevention of gastrointestinal cancers.
Topics: Alanine; Animals; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Dose-Response Relation | 1998 |
Positive effect of rebamipide on gastric permeability in mice after eradication of Helicobacter felis.
Topics: Alanine; Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Helicobacter; Helicobac | 2000 |
Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Interl | 2000 |
Therapeutic effects of oral rebamipide and in combination with cimetidine on experimental gastritis in rats.
Topics: Administration, Oral; Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Drug | 1992 |