ono4819 and Colitis

ono4819 has been researched along with Colitis* in 1 studies

Other Studies

1 other study(ies) available for ono4819 and Colitis

ArticleYear
Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128

    In the intestine, the formation of new lymphatic vessels from pre-existing lymphatic vasculature (lymphangiogenesis) is related to the progression of inflammatory bowel disease (IBD). However, it remains unclear whether lymphangiogenesis contributes to mucosal repair after acute colitis. Prostaglandin Ereceptor EP4 suppresses the development of experimental colitis. In this study, we investigated whether EP4 exerts this effect by contributing to lymphangiogenesis, in turn promoting mucosal tissue repair, following acute colitis. We elicited experimental colitis in male C57/BL6 mice by administering dextran sulphate sodium (DSS) via the drinking water for 5 days, followed by normal water for 9 additional days. From Day 5 through Day 13, the experimental mice received a daily dose of EP4-selective agonist, EP4-selective antagonist, or vehicle. On Day 14, mice treated with vehicle had recovered 95 % of body weight and exhibited moderate increases in disease activity and histological score relative to untreated controls. Compared with vehicle, post-treatment with EP4 antagonist increased signs of colitis, colonic tissue destruction, and CD11b

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Heptanoates; Intestinal Mucosa; Lymphangiogenesis; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Vascular Endothelial Growth Factor Receptor-3; Wound Healing

2020