ono-nt-126 and Colitis

We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD).. Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administered intraluminally via anus once a day. The rats were killed after 7 days for assessment of colonic damage by the colonic damage score.. ONO-NT-126 markedly reduced the colonic damage. Our findings suggest that the thromboxane-thromboxane receptor system plays an important role in this model of IBD and that antagonism of the thromboxane A2 receptor may prove useful for the treatment of IBD.

Topics: Animals; Bridged Bicyclo Compounds; Colitis; Colon; Dose-Response Relationship, Drug; Ethanol; Fatty Acids, Monounsaturated; Leukotriene B4; Male; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane A2; Trinitrobenzenesulfonic Acid