ono 1078 has been researched along with Sneezing in 5 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Sneezing: The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For the above purpose, we studied the effects of pranlukast and zafirlukast (cysteinyl leukotriene (cys-LT) receptor antagonists), seratrodast and ramatroban (thromboxane A(2) (TXA(2)) receptor antagonists) on nasal congestion and sneezing induced by toluene 2, 4-diisocyanate (TDI)." | 3.74 | Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats. ( Jiang, S; Kamei, C; Kishi, Y; Nakano, Y; Yatsuzuka, R, 2007) |
| "We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drug terfenadine and the glucocorticoid dexamethasone on antigen-induced sneezing, biphasic nasal blockage and nasal hyperresponsiveness to histamine using a guinea pig model of allergic rhinitis." | 3.71 | Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. ( Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M, 2001) |
| "Montelukast 5mg and 10mg were non-inferior to pranlukast 450mg in the change from the baseline in the composite nasal symptoms scores." | 2.73 | A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. ( Baba, K; Okubo, K, 2008) |
| "Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0." | 1.32 | Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig. ( Kohno, S; Mizutani, N; Nabe, T; Takenaka, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okubo, K | 1 |
| Baba, K | 1 |
| Mizutani, N | 2 |
| Nabe, T | 2 |
| Takenaka, H | 1 |
| Kohno, S | 2 |
| Kishi, Y | 1 |
| Nakano, Y | 1 |
| Jiang, S | 1 |
| Yatsuzuka, R | 1 |
| Kamei, C | 1 |
| Numata, T | 1 |
| Konno, A | 1 |
| Yamakoshi, T | 1 |
| Hanazawa, T | 1 |
| Terada, N | 1 |
| Nagata, H | 1 |
| Yamasaki, M | 1 |
| Sasaki, K | 1 |
| Matsumoto, T | 1 |
| Ashida, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mk0476 Phase II Dose Finding Study -Allergic Rhinitis-[NCT00446186] | Phase 2 | 945 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| MK0476 Phase III Double-Blind Comparative Study - Allergic Rhinitis[NCT00127647] | Phase 3 | 1,375 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ono 1078 and Sneezing
| Article | Year |
|---|---|
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
4 other studies available for ono 1078 and Sneezing
| Article | Year |
|---|---|
Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.
Topics: Animals; Antigens; Chromones; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Leukotr | 2003 |
Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.
Topics: Animals; Benzoquinones; Carbazoles; Chromones; Dose-Response Relationship, Drug; Heptanoic Acids; In | 2007 |
Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy.
Topics: Adolescent; Adult; Allergens; Animals; Chromones; Female; Histamine; Histamine H1 Antagonists; Human | 1999 |
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chrom | 2001 |