Page last updated: 2024-11-03

ono 1078 and Sneezing

ono 1078 has been researched along with Sneezing in 5 studies

pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist

Sneezing: The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.

Research Excerpts

ExcerptRelevanceReference
" For the above purpose, we studied the effects of pranlukast and zafirlukast (cysteinyl leukotriene (cys-LT) receptor antagonists), seratrodast and ramatroban (thromboxane A(2) (TXA(2)) receptor antagonists) on nasal congestion and sneezing induced by toluene 2, 4-diisocyanate (TDI)."3.74Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats. ( Jiang, S; Kamei, C; Kishi, Y; Nakano, Y; Yatsuzuka, R, 2007)
"We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drug terfenadine and the glucocorticoid dexamethasone on antigen-induced sneezing, biphasic nasal blockage and nasal hyperresponsiveness to histamine using a guinea pig model of allergic rhinitis."3.71Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. ( Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M, 2001)
"Montelukast 5mg and 10mg were non-inferior to pranlukast 450mg in the change from the baseline in the composite nasal symptoms scores."2.73A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. ( Baba, K; Okubo, K, 2008)
"Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0."1.32Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig. ( Kohno, S; Mizutani, N; Nabe, T; Takenaka, H, 2003)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Okubo, K1
Baba, K1
Mizutani, N2
Nabe, T2
Takenaka, H1
Kohno, S2
Kishi, Y1
Nakano, Y1
Jiang, S1
Yatsuzuka, R1
Kamei, C1
Numata, T1
Konno, A1
Yamakoshi, T1
Hanazawa, T1
Terada, N1
Nagata, H1
Yamasaki, M1
Sasaki, K1
Matsumoto, T1
Ashida, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mk0476 Phase II Dose Finding Study -Allergic Rhinitis-[NCT00446186]Phase 2945 participants (Actual)Interventional2004-02-29Completed
MK0476 Phase III Double-Blind Comparative Study - Allergic Rhinitis[NCT00127647]Phase 31,375 participants (Actual)Interventional2004-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for ono 1078 and Sneezing

ArticleYear
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
    Allergology international : official journal of the Japanese Society of Allergology, 2008, Volume: 57, Issue:4

    Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni

2008
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
    Allergology international : official journal of the Japanese Society of Allergology, 2008, Volume: 57, Issue:4

    Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni

2008
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
    Allergology international : official journal of the Japanese Society of Allergology, 2008, Volume: 57, Issue:4

    Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni

2008
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
    Allergology international : official journal of the Japanese Society of Allergology, 2008, Volume: 57, Issue:4

    Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni

2008

Other Studies

4 other studies available for ono 1078 and Sneezing

ArticleYear
Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.
    Journal of pharmacological sciences, 2003, Volume: 93, Issue:4

    Topics: Animals; Antigens; Chromones; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Leukotr

2003
Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.
    International immunopharmacology, 2007, Volume: 7, Issue:11

    Topics: Animals; Benzoquinones; Carbazoles; Chromones; Dose-Response Relationship, Drug; Heptanoic Acids; In

2007
Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy.
    The Annals of otology, rhinology, and laryngology, 1999, Volume: 108, Issue:5

    Topics: Adolescent; Adult; Allergens; Animals; Chromones; Female; Histamine; Histamine H1 Antagonists; Human

1999
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:9

    Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chrom

2001