ono 1078 has been researched along with Rhinitis, Allergic, Seasonal in 12 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Rhinitis, Allergic, Seasonal: Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season." | 5.14 | Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009) |
| "We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drug terfenadine and the glucocorticoid dexamethasone on antigen-induced sneezing, biphasic nasal blockage and nasal hyperresponsiveness to histamine using a guinea pig model of allergic rhinitis." | 3.71 | Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. ( Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M, 2001) |
| "Two goals of prophylactic treatment of pollinosis are use of fewer types of drugs and delay of onset of symptoms and impairement of QOL." | 2.76 | Delay of onset of symptoms of Japanese cedar pollinosis by treatment with a leukotriene receptor antagonist. ( Gotoh, M; Okubo, K; Suzuki, H, 2011) |
| "Montelukast 5mg and 10mg were non-inferior to pranlukast 450mg in the change from the baseline in the composite nasal symptoms scores." | 2.73 | A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. ( Baba, K; Okubo, K, 2008) |
| "However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
| " The robustness of the population pharmacokinetic model was evaluated by using 200 bootstrap samples." | 1.33 | Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. ( Higuchi, S; Miyata, Y; Nakade, S; Nakayama, K; Ohno, T; Ueda, S; Yukawa, E, 2006) |
| "Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0." | 1.32 | Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig. ( Kohno, S; Mizutani, N; Nabe, T; Takenaka, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okubo, K | 5 |
| Hashiguchi, K | 1 |
| Takeda, T | 1 |
| Baba, K | 2 |
| Kitagoh, H | 1 |
| Miho, H | 1 |
| Tomomatsu, H | 1 |
| Yamaguchi, S | 1 |
| Odani, M | 1 |
| Yamamotoya, H | 1 |
| Sasaki, K | 3 |
| Okamoto, Y | 2 |
| Yonekura, S | 2 |
| Okawa, T | 2 |
| Horiguchi, S | 2 |
| Chazono, H | 1 |
| Hisamitsu, M | 1 |
| Sakurai, D | 1 |
| Hanazawa, T | 2 |
| Sagara, H | 1 |
| Yukawa, T | 1 |
| Kashima, R | 1 |
| Okada, T | 1 |
| Fukuda, T | 1 |
| Gotoh, M | 2 |
| Suzuki, H | 2 |
| Kakuma, T | 1 |
| Konno, A | 1 |
| Okuda, M | 1 |
| Mizutani, N | 5 |
| Nabe, T | 4 |
| Takenaka, H | 2 |
| Kohno, S | 4 |
| Nakade, S | 1 |
| Ueda, S | 1 |
| Ohno, T | 1 |
| Nakayama, K | 1 |
| Miyata, Y | 1 |
| Yukawa, E | 1 |
| Higuchi, S | 1 |
| Han, HY | 1 |
| Fujii, M | 1 |
| Terada, T | 1 |
| Yamasaki, M | 1 |
| Matsumoto, T | 2 |
| Ashida, Y | 2 |
| Yamasaki, ML | 1 |
| Sakura, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mk0476 Phase II Dose Finding Study -Allergic Rhinitis-[NCT00446186] | Phase 2 | 945 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| MK0476 Phase III Double-Blind Comparative Study - Allergic Rhinitis[NCT00127647] | Phase 3 | 1,375 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ono 1078 and Rhinitis, Allergic, Seasonal
| Article | Year |
|---|---|
[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms].
Topics: Allergens; Animals; Bronchial Provocation Tests; Chromones; Cryptomeria; Disease Models, Animal; Gui | 2003 |
4 trials available for ono 1078 and Rhinitis, Allergic, Seasonal
| Article | Year |
|---|---|
A randomized controlled phase II clinical trial comparing ONO-4053, a novel DP1 antagonist, with a leukotriene receptor antagonist pranlukast in patients with seasonal allergic rhinitis.
Topics: Adult; Cell Degranulation; Chromones; Drug Therapy, Combination; Female; Humans; Leukotriene Antagon | 2017 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis.
Topics: Acetates; Adult; Chromones; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagoni | 2008 |
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig | 2009 |
Delay of onset of symptoms of Japanese cedar pollinosis by treatment with a leukotriene receptor antagonist.
Topics: Adult; Allergens; Anti-Asthmatic Agents; Chromones; Cryptomeria; Female; Humans; Leukotriene Antagon | 2011 |
7 other studies available for ono 1078 and Rhinitis, Allergic, Seasonal
| Article | Year |
|---|---|
Cedar and cypress pollinosis and allergic rhinitis: quality of life effects of early intervention with leukotriene receptor antagonists.
Topics: Administration, Oral; Adult; Aged; Chromones; Cryptomeria; Cupressus; Female; Humans; Leukotriene An | 2009 |
Beneficial effects of leukotriene receptor antagonists in the prevention of cedar pollinosis in a community setting.
Topics: Adult; Chromones; Cryptomeria; Double-Blind Method; Female; Humans; Leukotriene Antagonists; Male; M | 2009 |
Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.
Topics: Animals; Antigens; Chromones; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Leukotr | 2003 |
Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.
Topics: Adolescent; Algorithms; Anti-Asthmatic Agents; Asthma; Child; Child, Preschool; Chromones; Data Inte | 2006 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chrom | 2001 |
Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis.
Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory | 2001 |