ono 1078 has been researched along with Pulmonary Fibrosis in 2 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pranlukast attenuates the progression of pulmonary fibrosis in the chronic phase but has no effect on the acute inflammatory response or on the onset of pulmonary fibrosis." | 1.38 | Pranlukast, a cysteinyl leukotriene type 1 receptor antagonist, attenuates the progression but not the onset of silica-induced pulmonary fibrosis in mice. ( Okunishi, H; Shimbori, C; Shiota, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fireman, E | 1 |
| Shimbori, C | 1 |
| Shiota, N | 1 |
| Okunishi, H | 1 |
2 other studies available for ono 1078 and Pulmonary Fibrosis
| Article | Year |
|---|---|
A silica-induced pulmonary fibrosis model: are we closer to 'real life'?
Topics: Animals; Chromones; Female; Leukotriene Antagonists; Pulmonary Fibrosis; Silicon Dioxide | 2012 |
Pranlukast, a cysteinyl leukotriene type 1 receptor antagonist, attenuates the progression but not the onset of silica-induced pulmonary fibrosis in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chromones; Cytokines; Disease Progression; Female; Hydroxypro | 2012 |