ono 1078 has been researched along with Bronchial Hyperreactivity in 21 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Albeit its exact pathogenesis is still ambiguous; aspirin-intolerant asthma is one of several types of asthma for which antileukotriene therapy is useful, because it is widely accepted that bronchial over-production of leukotrienes may be involved in its pathogenesis." | 9.09 | Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma. ( Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Onuma, K; Sakamoto, H; Shoji, T; Yoshida, S, 2000) |
| "Cysteinyl leukotrienes (cysLTs) are considered to be the most important mediator involved in the pathogenesis of aspirin-intolerant asthma (AIA)." | 7.70 | Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids. ( Haruta, Y; Hiyama, K; Hozawa, S; Ishioka, S; Maeda, A; Tamagawa, K; Watanabe, T; Yamakido, M, 2000) |
| "The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season." | 5.14 | Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009) |
| "Albeit its exact pathogenesis is still ambiguous; aspirin-intolerant asthma is one of several types of asthma for which antileukotriene therapy is useful, because it is widely accepted that bronchial over-production of leukotrienes may be involved in its pathogenesis." | 5.09 | Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma. ( Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Onuma, K; Sakamoto, H; Shoji, T; Yoshida, S, 2000) |
| "The effects of lipid mediator antagonists: the LTD4-receptor antagonist pranlukast, the TXA2-receptor antagonist seratrodast, and the novel dual LTD4- and TXA2-receptor antagonist YM158 (3-[(4-tert-butylthiazol-2-yl)methoxy]-5'-[3-(4-chlorobenzenesu lfonyl) propyl]-2'-(1H-tetrazol-5-ylmethoxy)benzanilide monosodium salt monohydrate) were investigated in animals exhibiting immediate asthmatic response (IAR), late asthmatic response (LAR) and airway hyper-responsiveness (AHR)." | 3.70 | Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs. ( Arakida, Y; Honda, K; Miyata, K; Morio, H; Ohga, K; Okada, Y; Suwa, K; Yamada, T; Yokota, M, 2000) |
| "Cysteinyl leukotrienes (cysLTs) are considered to be the most important mediator involved in the pathogenesis of aspirin-intolerant asthma (AIA)." | 3.70 | Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids. ( Haruta, Y; Hiyama, K; Hozawa, S; Ishioka, S; Maeda, A; Tamagawa, K; Watanabe, T; Yamakido, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyagawa, N | 1 |
| Iwasaki, H | 1 |
| Kato, T | 1 |
| Tanaka, M | 1 |
| Shibata, T | 1 |
| Wakitani, K | 1 |
| Sagara, H | 1 |
| Yukawa, T | 1 |
| Kashima, R | 1 |
| Okada, T | 1 |
| Fukuda, T | 1 |
| Mizutani, N | 1 |
| Inui, S | 1 |
| Yoshino, S | 1 |
| Nabe, T | 1 |
| Fujimoto, K | 1 |
| Yamaguchi, S | 2 |
| Urushibata, K | 1 |
| Koizumi, T | 1 |
| Kubo, K | 1 |
| Kawano, T | 1 |
| Matsuse, H | 1 |
| Kondo, Y | 1 |
| Machida, I | 1 |
| Saeki, S | 1 |
| Tomari, S | 1 |
| Mitsuta, K | 1 |
| Obase, Y | 1 |
| Fukushima, C | 1 |
| Shimoda, T | 1 |
| Kohno, S | 1 |
| Parameswaran, K | 1 |
| Liang, H | 1 |
| Fanat, A | 1 |
| Watson, R | 1 |
| Snider, DP | 1 |
| O'Byrne, PM | 1 |
| Okunishi, K | 1 |
| Dohi, M | 1 |
| Nakagome, K | 1 |
| Tanaka, R | 1 |
| Yamamoto, K | 1 |
| Lee, KS | 1 |
| Kim, SR | 1 |
| Park, HS | 1 |
| Jin, GY | 1 |
| Lee, YC | 1 |
| Taki, F | 1 |
| Suzuki, R | 1 |
| Torii, K | 1 |
| Matsumoto, S | 1 |
| Taniguchi, H | 1 |
| Takagi, K | 1 |
| Kurosawa, M | 2 |
| Yodonawa, S | 2 |
| Tsukagoshi, H | 2 |
| Miyachi, Y | 1 |
| Fujimura, M | 2 |
| Sakamoto, S | 1 |
| Kamio, Y | 1 |
| Matsuda, T | 2 |
| Misawa, M | 1 |
| Sugiyama, Y | 1 |
| Myou, S | 1 |
| Amemiya, T | 1 |
| Tachibana, H | 1 |
| Kita, T | 1 |
| Kagoshima, M | 1 |
| Tomomatsu, N | 1 |
| Iwahisa, Y | 1 |
| Matsuura, M | 1 |
| Kawakami, Y | 1 |
| Terasawa, M | 1 |
| Nagase, T | 1 |
| Ishii, S | 1 |
| Katayama, H | 1 |
| Fukuchi, Y | 1 |
| Ouchi, Y | 1 |
| Shimizu, T | 1 |
| Hisada, T | 1 |
| Salmon, M | 1 |
| Nasuhara, Y | 1 |
| Chung, KF | 1 |
| Yoshida, S | 1 |
| Sakamoto, H | 1 |
| Ishizaki, Y | 1 |
| Onuma, K | 1 |
| Shoji, T | 1 |
| Nakagawa, H | 1 |
| Hasegawa, H | 1 |
| Nakabayashi, M | 1 |
| Amayasu, H | 1 |
| Arakida, Y | 1 |
| Ohga, K | 1 |
| Suwa, K | 1 |
| Okada, Y | 1 |
| Morio, H | 1 |
| Yokota, M | 1 |
| Miyata, K | 1 |
| Yamada, T | 1 |
| Honda, K | 1 |
| Ishioka, S | 1 |
| Hozawa, S | 1 |
| Haruta, Y | 1 |
| Maeda, A | 1 |
| Tamagawa, K | 1 |
| Watanabe, T | 1 |
| Hiyama, K | 1 |
| Yamakido, M | 1 |
| Asano, M | 1 |
| Inamura, N | 1 |
| Nakahara, K | 1 |
| Nagayoshi, A | 1 |
| Isono, T | 1 |
| Hamada, K | 1 |
| Oku, T | 1 |
| Notsu, Y | 1 |
| Kohsaka, M | 1 |
| Ono, T | 1 |
| Aoki, S | 1 |
4 trials available for ono 1078 and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig | 2009 |
Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma.
Topics: Adult; Allergens; Asthma; Bronchial Hyperreactivity; Cell Count; Chemotactic Factors; Chromones; Cro | 2004 |
Effect of a leukotriene antagonist, ONO-1078, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chromones; Double-Blind | 1993 |
Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma.
Topics: Adult; Analgesics; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; | 2000 |
17 other studies available for ono 1078 and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Two pharmacological phases in antigen-induced immediate airway response in rats.
Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Albutero | 2008 |
Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchial Hyperreactivity; Chro | 2010 |
Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; | 2003 |
Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchitis; Chemokine CCL5; | 2003 |
A novel role of cysteinyl leukotrienes to promote dendritic cell activation in the antigen-induced immune responses in the lung.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arachidonate 5-L | 2004 |
Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.
Topics: Acetates; Animals; Bronchial Hyperreactivity; Capillary Permeability; Chromones; Cyclopropanes; Cyto | 2004 |
Reduction of the severity of bronchial hyperresponsiveness by the novel leukotriene antagonist 4-oxo-8-[4-(4-phenyl-butoxy)benzoylamino]-2- (tetrazol-5-yl)-4H-1-benzopyran hemihydrate.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Chromones; Female; Forced Expirator | 1994 |
Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Chromones; Guinea Pigs; Histamine; Image Proc | 1994 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromone | 1993 |
Peptide leukotrienes mediate acetaldehyde-induced bronchial hyper-responsiveness in guinea-pigs.
Topics: Acetaldehyde; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepin | 1997 |
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene | 1997 |
Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice.
Topics: Acetylcholine; Airway Resistance; Animals; Benzofurans; Bronchial Hyperreactivity; Bronchial Provoca | 1999 |
Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Benzoquinones; B | 2000 |
Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aspirin; Asthma; Bronchial Hyperreactivity; Chromones; Drug To | 2000 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans | 1992 |
[Bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 (LTC4) and LTD4 in guinea pigs].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Chromones; Guinea Pigs; Hist | 1992 |