ono 1078 has been researched along with Brain Ischemia in 11 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats." | 7.72 | [Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004) |
| "Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls." | 5.33 | Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005) |
| "To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats." | 3.72 | [Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004) |
| "Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls." | 1.33 | Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005) |
| "Focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO)." | 1.33 | Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice. ( Chen, Z; Chu, LS; Fang, SH; Wang, ML; Wei, EQ; Weng, JQ; Yu, GL; Zhang, LH; Zhang, Q; Zhang, SH; Zhang, WP; Zhou, Y, 2005) |
| "Focal cerebral ischemia in mice was induced by permanent middle cerebral artery occlusion (MCAO)." | 1.33 | Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice. ( Chu, LS; Fang, SH; Wang, ML; Wei, EQ; Yu, GL; Zhang, WP; Zhou, Y, 2006) |
| "Transient global cerebral ischemia was induced by four-vessel occlusion for 10 min and followed by 72-h reperfusion." | 1.32 | Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats. ( Wei, EQ; Zhang, LH, 2003) |
| "After middle cerebral artery occlusion (MCAO), the neurological deficits were evaluated 24 h later." | 1.32 | [An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia]. ( Wei, EQ; Xu, QQ; Yu, YP; Zheng, MZ; Zhu, CY; Zhu, YF, 2003) |
| "Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice." | 1.31 | [Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice]. ( Wang, PL; Wang, RD; Wei, EQ; Zeng, LH; Zhang, WP, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, QJ | 1 |
| Wang, H | 1 |
| Liu, ZX | 1 |
| Fang, SH | 5 |
| Song, XM | 1 |
| Lu, YB | 2 |
| Zhang, WP | 7 |
| Sa, XY | 1 |
| Ying, HZ | 1 |
| Wei, EQ | 11 |
| Lin, KN | 1 |
| Huang, XQ | 1 |
| Zeng, LH | 1 |
| Wang, RD | 1 |
| Wang, PL | 1 |
| Zhang, LH | 2 |
| Zhu, CY | 2 |
| Xu, QQ | 1 |
| Yu, YP | 1 |
| Zhu, YF | 1 |
| Zheng, MZ | 1 |
| Zhang, SH | 3 |
| Chen, Z | 4 |
| Zhang, SF | 1 |
| Li, W | 1 |
| Wang, ML | 4 |
| Liu, LY | 1 |
| Yu, GL | 4 |
| Xu, HM | 1 |
| Chu, LS | 4 |
| Zhang, Q | 2 |
| Mei, RH | 1 |
| Zhao, MH | 1 |
| Weng, JQ | 1 |
| Zhou, Y | 3 |
11 other studies available for ono 1078 and Brain Ischemia
| Article | Year |
|---|---|
HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Chromones; Cyclohexanecarboxylic Acids; | 2015 |
Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
Topics: Apoptosis; Brain Ischemia; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Membrane; Cell Nuc | 2012 |
[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].
Topics: Animals; Brain; Brain Ischemia; Chromones; Dexamethasone; Infarction, Middle Cerebral Artery; Leukot | 2001 |
Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Chromones; Disease Models, Animal; Hippocampus; Ischemic A | 2003 |
[An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia].
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Chromones; Female; Hippocampus; Infarction, Middle | 2003 |
[Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats].
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Chromo | 2004 |
[Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].
Topics: Animals; Anti-Bacterial Agents; Antipyrine; Brain Ischemia; Chromones; Edaravone; Evoked Potentials; | 2004 |
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.
Topics: Acetates; Animals; Antipyrine; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Chromones; C | 2005 |
Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Cell Count; Chromones; Chronic Dise | 2005 |
Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; CD11b Antigen; Chromones; Immunoglobulin G | 2006 |
Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Cerebral Infarction; Chromones; Disease Models, Animal; Encepha | 2006 |