Page last updated: 2024-11-03

ono 1078 and Brain Ischemia

ono 1078 has been researched along with Brain Ischemia in 11 studies

pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats."7.72[Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004)
"Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls."5.33Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005)
"To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats."3.72[Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004)
"Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls."1.33Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005)
"Focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO)."1.33Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice. ( Chen, Z; Chu, LS; Fang, SH; Wang, ML; Wei, EQ; Weng, JQ; Yu, GL; Zhang, LH; Zhang, Q; Zhang, SH; Zhang, WP; Zhou, Y, 2005)
"Focal cerebral ischemia in mice was induced by permanent middle cerebral artery occlusion (MCAO)."1.33Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice. ( Chu, LS; Fang, SH; Wang, ML; Wei, EQ; Yu, GL; Zhang, WP; Zhou, Y, 2006)
"Transient global cerebral ischemia was induced by four-vessel occlusion for 10 min and followed by 72-h reperfusion."1.32Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats. ( Wei, EQ; Zhang, LH, 2003)
"After middle cerebral artery occlusion (MCAO), the neurological deficits were evaluated 24 h later."1.32[An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia]. ( Wei, EQ; Xu, QQ; Yu, YP; Zheng, MZ; Zhu, CY; Zhu, YF, 2003)
"Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice."1.31[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice]. ( Wang, PL; Wang, RD; Wei, EQ; Zeng, LH; Zhang, WP, 2001)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (81.82)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shi, QJ1
Wang, H1
Liu, ZX1
Fang, SH5
Song, XM1
Lu, YB2
Zhang, WP7
Sa, XY1
Ying, HZ1
Wei, EQ11
Lin, KN1
Huang, XQ1
Zeng, LH1
Wang, RD1
Wang, PL1
Zhang, LH2
Zhu, CY2
Xu, QQ1
Yu, YP1
Zhu, YF1
Zheng, MZ1
Zhang, SH3
Chen, Z4
Zhang, SF1
Li, W1
Wang, ML4
Liu, LY1
Yu, GL4
Xu, HM1
Chu, LS4
Zhang, Q2
Mei, RH1
Zhao, MH1
Weng, JQ1
Zhou, Y3

Other Studies

11 other studies available for ono 1078 and Brain Ischemia

ArticleYear
HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats.
    Neuroscience, 2015, Apr-16, Volume: 291

    Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Chromones; Cyclohexanecarboxylic Acids;

2015
Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:12

    Topics: Apoptosis; Brain Ischemia; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Membrane; Cell Nuc

2012
[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Chromones; Dexamethasone; Infarction, Middle Cerebral Artery; Leukot

2001
Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on transient global cerebral ischemia in rats.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:12

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Chromones; Disease Models, Animal; Hippocampus; Ischemic A

2003
[An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia].
    Sheng li xue bao : [Acta physiologica Sinica], 2003, Dec-25, Volume: 55, Issue:6

    Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Chromones; Female; Hippocampus; Infarction, Middle

2003
[Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:1

    Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Chromo

2004
[Effects of edaravone, minocycline and ONO-1078 on oxygen/glucose deprivation-induced electrophysiological alteration in rat hippocampal slices].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Antipyrine; Brain Ischemia; Chromones; Edaravone; Evoked Potentials;

2004
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.
    Pharmacology, 2005, Volume: 73, Issue:1

    Topics: Acetates; Animals; Antipyrine; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Chromones; C

2005
Pranlukast, a cysteinyl leukotriene receptor-1 antagonist, protects against chronic ischemic brain injury and inhibits the glial scar formation in mice.
    Brain research, 2005, Aug-16, Volume: 1053, Issue:1-2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Cell Count; Chromones; Chronic Dise

2005
Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; CD11b Antigen; Chromones; Immunoglobulin G

2006
Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.
    Neuroscience, 2006, Jul-07, Volume: 140, Issue:3

    Topics: Animals; Astrocytes; Brain Ischemia; Cerebral Infarction; Chromones; Disease Models, Animal; Encepha

2006