ono 1078 has been researched along with Brain Edema in 5 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats." | 7.72 | [Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004) |
| "Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls." | 5.33 | Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005) |
| "To determine the protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats." | 3.72 | [Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats]. ( Chen, Z; Wei, EQ; Zhang, SF; Zhang, SH; Zhu, CY, 2004) |
| "Montelukast was injected intraperitoneally either as multiple doses (once a day for 3 days and 30 min before MCAO) or as a single dose (at 30 min before, 30 min after, or 1 h after MCAO), respectively, and pranlukast and edaravone were used as controls." | 1.33 | Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. ( Chen, Z; Chu, LS; Mei, RH; Wei, EQ; Xu, HM; Yu, GL; Zhang, Q; Zhang, SH; Zhang, WP; Zhao, MH, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, QJ | 1 |
| Wang, H | 1 |
| Liu, ZX | 1 |
| Fang, SH | 1 |
| Song, XM | 1 |
| Lu, YB | 1 |
| Zhang, WP | 4 |
| Sa, XY | 1 |
| Ying, HZ | 1 |
| Wei, EQ | 5 |
| Mei, RH | 2 |
| Zhu, CY | 2 |
| Zhao, MH | 2 |
| Zhang, SH | 2 |
| Chen, Z | 3 |
| Zhang, SF | 1 |
| Yu, GL | 1 |
| Xu, HM | 1 |
| Chu, LS | 1 |
| Zhang, Q | 1 |
| Qian, XD | 1 |
| Zhang, L | 1 |
| Sheng, WW | 1 |
| Wang, ML | 1 |
5 other studies available for ono 1078 and Brain Edema
| Article | Year |
|---|---|
HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Chromones; Cyclohexanecarboxylic Acids; | 2015 |
Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Chromones; Infarction, Middle Cerebral Artery; Leukotrien | 2002 |
[Protective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia induced by endothelin-1 in rats].
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Chromo | 2004 |
Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice.
Topics: Acetates; Animals; Antipyrine; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Chromones; C | 2005 |
Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, protects mice against brain cold injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cell Count; Chromones; Cold Temperature; Dose-Response | 2006 |