ono 1078 has been researched along with Asthma in 114 studies
pranlukast: SRS-A antagonist; leukotriene D4 receptor antagonist
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results support the hypothesis that cysteinyl leukotriene is one of the most important components in the pathogenesis of aspirin-intolerant asthma." | 9.09 | Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma. ( Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Onuma, K; Sakamoto, H; Shoji, T; Yoshida, S, 2000) |
| "Acetaldehyde is a main factor of alcohol-induced asthma." | 9.09 | Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. ( Abo, M; Fujimura, M; Hashimoto, T; Kamio, Y; Katayama, N; Kita, T; Myou, S; Nakao, S; Nishitsuji, M; Nomura, S; Yoshimi, Y, 2001) |
| "Our results indicated that aspirin-induced asthma is associated with overproduction of LT with a shift to the 5-lipoxygenase series of the arachidonate cascade and that leukotriene receptor antagonist are useful for AIA through inhibition of production of LT and eosinophilic inflammation in the airway." | 7.71 | Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. ( Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, S, 2001) |
| "House dust mite (HDM) inhalation provocation tests were performed in HDM-sensitive asthmatic inpatients without AIA (HDM group; n = 6), and aspirin oral provocation tests were performed in AIA patients (ASA group; n = 7)." | 7.71 | Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. ( Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, SY, 2002) |
| "Cysteinyl leukotrienes (cysLTs) are considered to be the most important mediator involved in the pathogenesis of aspirin-intolerant asthma (AIA)." | 7.70 | Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids. ( Haruta, Y; Hiyama, K; Hozawa, S; Ishioka, S; Maeda, A; Tamagawa, K; Watanabe, T; Yamakido, M, 2000) |
| "The prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide." | 6.50 | Leukotriene receptor antagonists pranlukast and montelukast for treating asthma. ( Kohno, S; Matsuse, H, 2014) |
| "Among patients in whom coughing developed during the peak pollen season, airway responsiveness significantly increased in the fexofenadine group." | 5.14 | Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009) |
| "These results support the hypothesis that cysteinyl leukotriene is one of the most important components in the pathogenesis of aspirin-intolerant asthma." | 5.09 | Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma. ( Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Onuma, K; Sakamoto, H; Shoji, T; Yoshida, S, 2000) |
| "beta-adrenoreceptor blockers such as propranolol provoke bronchoconstriction only in asthmatic patients." | 5.09 | Effect of leukotriene and thromboxane antagonist on propranolol-induced bronchoconstriction. ( Abo, M; Fujimura, M; Hashimoto, T; Ishiura, Y; Kamio, Y; Matsuda, T; Myou, S, 1999) |
| "Acetaldehyde is a main factor of alcohol-induced asthma." | 5.09 | Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. ( Abo, M; Fujimura, M; Hashimoto, T; Kamio, Y; Katayama, N; Kita, T; Myou, S; Nakao, S; Nishitsuji, M; Nomura, S; Yoshimi, Y, 2001) |
| "We evaluated the effect of ONO-1078, a selective leukotriene-C4, -D4, and -E4-receptor antagonist, on bronchoconstriction intensity during inhalation challenge with dipyrone (a pyrazolone derivative) in six aspirin-sensitive asthmatics." | 5.07 | Inhibition of analgesic-induced asthma by leukotriene receptor antagonist ONO-1078. ( Dohi, Y; Kiuchi, H; Kuramitsu, K; Nagata, M; Sakamoto, Y; Tabe, K; Yamamoto, H; Yamamoto, K, 1994) |
| " Recognition of the involvement of cysLTs in the immunopathogenesis of various types of acute and chronic inflammatory disorders, especially bronchial asthma, prompted the development of selective cysLT receptor-1 (cysLTR1) antagonists, specifically montelukast, pranlukast, and zafirlukast." | 4.90 | Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function. ( Anderson, R; Feldman, C; Gravett, CM; Steel, HC; Theron, AJ; Tintinger, GR, 2014) |
| "Our results indicated that aspirin-induced asthma is associated with overproduction of LT with a shift to the 5-lipoxygenase series of the arachidonate cascade and that leukotriene receptor antagonist are useful for AIA through inhibition of production of LT and eosinophilic inflammation in the airway." | 3.71 | Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. ( Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, S, 2001) |
| "House dust mite (HDM) inhalation provocation tests were performed in HDM-sensitive asthmatic inpatients without AIA (HDM group; n = 6), and aspirin oral provocation tests were performed in AIA patients (ASA group; n = 7)." | 3.71 | Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. ( Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, SY, 2002) |
| "Zafirlukast, montelukast and pranlukast are all cysteinyl leukotriene receptor antagonists that have recently been approved for the treatment of asthma." | 3.70 | Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal? ( Drazen, JM; Pauwels, R; Wechsler, ME, 1999) |
| "Cysteinyl leukotrienes (cysLTs) are considered to be the most important mediator involved in the pathogenesis of aspirin-intolerant asthma (AIA)." | 3.70 | Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids. ( Haruta, Y; Hiyama, K; Hozawa, S; Ishioka, S; Maeda, A; Tamagawa, K; Watanabe, T; Yamakido, M, 2000) |
| "The effects of lipid mediator antagonists: the LTD4-receptor antagonist pranlukast, the TXA2-receptor antagonist seratrodast, and the novel dual LTD4- and TXA2-receptor antagonist YM158 (3-[(4-tert-butylthiazol-2-yl)methoxy]-5'-[3-(4-chlorobenzenesu lfonyl) propyl]-2'-(1H-tetrazol-5-ylmethoxy)benzanilide monosodium salt monohydrate) were investigated in animals exhibiting immediate asthmatic response (IAR), late asthmatic response (LAR) and airway hyper-responsiveness (AHR)." | 3.70 | Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs. ( Arakida, Y; Honda, K; Miyata, K; Morio, H; Ohga, K; Okada, Y; Suwa, K; Yamada, T; Yokota, M, 2000) |
| "The contributions of histamine, cysteinyl leukotrienes (CysLTs) and thromboxane A2 (TXA2) to the asthmatic responses and the magnitudes of blood and lung eosinophilia at acute and chronic stages of our asthmatic model were comparatively determined." | 3.70 | Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs. ( Kohno, S; Nabe, T; Tomioka, H; Yamashita, K, 1999) |
| "Serum levels of leukotriene (LT) B(4), LTC(4), platelet- activating factor, histamine, IL-1beta, IL-4, IL-5, IL-6, and GM-CSF were measured at different time points, first just before or during menstruation when the peak expiratory flow rate (PEFR) began to decrease precipitously and second during the menstrual midcycle week (days 10-16) when the PEFR returned to baseline values in patients with PMA and in age-matched asthma patients without PMA at the same intervals." | 3.70 | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. ( Matsui, T; Nakasato, H; Ohrui, T; Sasaki, H; Sekizawa, K; Tamura, G; Yamaya, M, 1999) |
| "Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbation." | 2.77 | Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection. ( Fukahori, S; Fukushima, C; Kawano, T; Kohno, S; Matsuo, N; Matsuse, H; Nishino, T; Tomari, S; Tsuchida, T, 2012) |
| " All but two patients continued to receive pranlukast and no adverse effects were noted, at least during the 16-week therapy." | 2.70 | Efficacy and safety of long-term treatment of asthmatic patients with pranlukast, a cysteinyl-leukotriene-receptor antagonist: four-year followup study. ( Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, S, 2001) |
| "To investigate the effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, in patients with moderate/severe asthma, when combined with beclomethasone dipropionate (BDP)." | 2.70 | Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma. ( Fukushima, C; Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, S, 2001) |
| "Seratrodast did not suppress IAR or LAR." | 2.69 | Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma. ( Asai, S; Kohno, S; Matsuo, N; Matsuse, H; Obase, Y; Shimoda, T, 1998) |
| " In general, after both single and repeated doses, there were related increases in the corresponding Cmax and AUC with a rise in dose, although the increase was diminished at doses above 450 mg." | 2.68 | The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers. ( Allen, E; Brocks, DR; Dennis, MJ; Doyle, E; Georgiou, P; Stelman, G; Upward, JW; Wyld, P, 1996) |
| " Improvements in trough FEV1-that is, at the end of the dosing interval-were statistically significant for the group treated with pranlukast 225 mg twice daily compared with placebo at week 4." | 2.68 | Pranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma. ( Barnes, NC; Pujet, JC, 1997) |
| "The prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide." | 2.50 | Leukotriene receptor antagonists pranlukast and montelukast for treating asthma. ( Kohno, S; Matsuse, H, 2014) |
| " The drug at this dosage was superior to both comparators in improving mean attack scores and morning and/or evening peak expiratory flow rates, and decreasing the use of rescue bronchodilators (p < 0." | 2.42 | Pranlukast: a review of its use in the management of asthma. ( Goa, KL; Keam, SJ; Lyseng-Williamson, KA, 2003) |
| " This dosage is also as effective when added to low-dosage inhaled corticosteroid therapy as doubling of corticosteroid dosages." | 2.41 | Zafirlukast: an update of its pharmacology and therapeutic efficacy in asthma. ( Dunn, CJ; Goa, KL, 2001) |
| " However, the effects of pharmacokinetic variability are less well known." | 1.35 | Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics. ( Asano, K; Fujita, H; Fukunaga, K; Ishizaka, A; Nakade, S; Nakajima, T; Oguma, T; Sayama, K; Shiomi, T; Suzuki, Y; Tanigawara, Y, 2009) |
| " The robustness of the population pharmacokinetic model was evaluated by using 200 bootstrap samples." | 1.33 | Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. ( Higuchi, S; Miyata, Y; Nakade, S; Nakayama, K; Ohno, T; Ueda, S; Yukawa, E, 2006) |
| "Fifteen men with bronchial asthma were studied for 5 years." | 1.32 | Clinical evaluation of response to long-term treatment with Pranlukast in patients with bronchial asthma. ( Hayashi, T; Izawa, J; Maruoka, N; Matsumura, Y; Morita, S; Niitsuma, T; Nukaga, M; Okita, M; Sakurai, K; Tsuji, A; Tsuyuguchi, M, 2004) |
| "Eighty-one adult patients with bronchial asthma who suffered from an unstable peak expiratory flow rate (PEFR) and asthmatic attacks that developed at irregular intervals in spite of inhaling beclometasone dipropionate (CAS 5534-09-8, BDP) in excess of 400 micrograms/day were treated with pranlukast (CAS 103177-37-3, Onon) 450 mg/day for 1 to 2 years and the clinical effects of its long-term administration were studied." | 1.32 | Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma. ( Hirose, M; Horiguchi, T; Ito, T; Kondo, R; Shiga, M; Tachikawa, S, 2003) |
| "Allergic airway eosinophilia is suppressed by cysteinyl leukotriene (CysLT) receptor (CysLT1 receptor) antagonists in several species including humans and guinea-pigs, suggesting that CysLTs are directly or indirectly involved in induction of the response." | 1.31 | Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. ( Kawai, T; Kohno, S; Miura, M; Nabe, T; Yamashita, K, 2002) |
| " The estimated geometric mean AUCO-t and Cmax ratios (95% CI in parentheses) for elderly : young were 1." | 1.29 | The pharmacokinetics of pranlukast in healthy young and elderly subjects. ( Brocks, DR; Collie, H; Dennis, MJ; Hust, R; Köester, FE; Qian, Y; Upward, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.88) | 18.7374 |
| 1990's | 47 (41.23) | 18.2507 |
| 2000's | 55 (48.25) | 29.6817 |
| 2010's | 11 (9.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Itadani, S | 1 |
| Yashiro, K | 1 |
| Aratani, Y | 1 |
| Sekiguchi, T | 1 |
| Kinoshita, A | 1 |
| Moriguchi, H | 1 |
| Ohta, N | 1 |
| Takahashi, S | 1 |
| Ishida, A | 1 |
| Tajima, Y | 1 |
| Hisaichi, K | 1 |
| Ima, M | 1 |
| Ueda, J | 1 |
| Egashira, H | 1 |
| Sekioka, T | 1 |
| Kadode, M | 1 |
| Yonetomi, Y | 1 |
| Nakao, T | 1 |
| Inoue, A | 1 |
| Nomura, H | 1 |
| Kitamine, T | 1 |
| Fujita, M | 1 |
| Nabe, T | 5 |
| Yamaura, Y | 1 |
| Matsumura, N | 1 |
| Imagawa, A | 1 |
| Nakayama, Y | 1 |
| Takeuchi, J | 1 |
| Ohmoto, K | 1 |
| Hur, J | 1 |
| Kang, JY | 1 |
| Rhee, CK | 1 |
| Kim, YK | 1 |
| Lee, SY | 1 |
| Pike, KC | 1 |
| Akhbari, M | 1 |
| Kneale, D | 1 |
| Harris, KM | 1 |
| Matsuse, H | 13 |
| Kohno, S | 16 |
| Kawano, T | 11 |
| Tsuchida, T | 3 |
| Fukahori, S | 3 |
| Fukushima, C | 10 |
| Nishino, T | 2 |
| Theron, AJ | 1 |
| Steel, HC | 1 |
| Tintinger, GR | 1 |
| Gravett, CM | 1 |
| Anderson, R | 1 |
| Feldman, C | 1 |
| Harada, S | 1 |
| Harada, N | 1 |
| Itoigawa, Y | 1 |
| Katsura, Y | 1 |
| Kasuga, F | 1 |
| Ishimori, A | 1 |
| Makino, F | 1 |
| Ito, J | 1 |
| Atsuta, R | 1 |
| Takahashi, K | 1 |
| Tomari, S | 9 |
| Hirose, H | 1 |
| Matsuo, N | 3 |
| Matsunaga, K | 1 |
| Yanagisawa, S | 1 |
| Ichikawa, T | 1 |
| Akamatsu, K | 1 |
| Koarai, A | 1 |
| Hirano, T | 1 |
| Sugiura, H | 1 |
| Minakata, Y | 1 |
| Ichinose, M | 1 |
| Sagara, H | 1 |
| Yukawa, T | 1 |
| Kashima, R | 1 |
| Okada, T | 1 |
| Fukuda, T | 1 |
| Asano, K | 2 |
| Nakade, S | 2 |
| Shiomi, T | 2 |
| Nakajima, T | 1 |
| Suzuki, Y | 2 |
| Fukunaga, K | 2 |
| Oguma, T | 1 |
| Sayama, K | 1 |
| Fujita, H | 1 |
| Tanigawara, Y | 1 |
| Ishizaka, A | 1 |
| Mizutani, N | 1 |
| Inui, S | 1 |
| Yoshino, S | 1 |
| Watanabe, S | 1 |
| Aizawa-Yashiro, T | 1 |
| Tsuruga, K | 1 |
| Takahashi, T | 1 |
| Ito, E | 1 |
| Tanaka, H | 3 |
| Yasui, H | 1 |
| Fujisawa, T | 1 |
| Inui, N | 1 |
| Kato, M | 1 |
| Hashimoto, D | 1 |
| Enomoto, N | 1 |
| Nakamura, Y | 2 |
| Shirai, T | 2 |
| Suda, T | 1 |
| Nakamura, H | 2 |
| Chida, K | 2 |
| Baba, K | 2 |
| Sakakibara, A | 2 |
| Yagi, T | 2 |
| Niwa, S | 2 |
| Wakayama, H | 1 |
| Takagi, K | 2 |
| Hasegawa, N | 1 |
| Kudo, H | 1 |
| Matsuzaki, T | 1 |
| Hakuno, H | 1 |
| Kanazawa, M | 1 |
| Yamaguchi, K | 2 |
| Terashima, T | 1 |
| Amakawa, K | 1 |
| Matsumaru, A | 1 |
| Horiguchi, T | 5 |
| Tachikawa, S | 5 |
| Kondo, R | 4 |
| Miyazaki, J | 3 |
| Sasaki, Y | 1 |
| Banno, K | 1 |
| Handa, M | 1 |
| Keam, SJ | 1 |
| Lyseng-Williamson, KA | 1 |
| Goa, KL | 2 |
| Fujimoto, K | 1 |
| Yamaguchi, S | 3 |
| Urushibata, K | 1 |
| Koizumi, T | 1 |
| Kubo, K | 1 |
| Machida, I | 4 |
| Kondo, Y | 4 |
| Obase, Y | 9 |
| Shimoda, T | 7 |
| Choi, IS | 1 |
| Koh, YI | 1 |
| Joo, JY | 1 |
| Lee, SH | 1 |
| Bae, WG | 1 |
| Saeki, S | 3 |
| Mitsuta, K | 5 |
| Katsura, T | 1 |
| Yoshida, F | 1 |
| Takinishi, Y | 1 |
| Shiga, M | 4 |
| Sugiyama, M | 1 |
| Hirose, M | 3 |
| Ito, T | 1 |
| Kobayashi, S | 2 |
| Ishizuka, S | 1 |
| Tamura, N | 1 |
| Takaya, M | 1 |
| Kaneda, K | 1 |
| Hashimoto, H | 1 |
| Kemp, JP | 1 |
| Parameswaran, K | 2 |
| Watson, R | 2 |
| Gauvreau, GM | 1 |
| Sehmi, R | 1 |
| O'Byrne, PM | 3 |
| Yanagawa, H | 1 |
| Sugita, A | 1 |
| Azuma, M | 1 |
| Ogawa, H | 1 |
| Kitamuro, C | 1 |
| Yoneda, K | 1 |
| Shinkawa, K | 1 |
| Tani, K | 1 |
| Sone, S | 1 |
| Kanazawa, H | 1 |
| Yoshikawa, T | 1 |
| Hirata, K | 1 |
| Yoshikawa, J | 1 |
| Liang, H | 1 |
| Fanat, A | 1 |
| Snider, DP | 1 |
| Shimbo, J | 1 |
| Onodera, O | 1 |
| Tanaka, K | 1 |
| Tsuji, S | 1 |
| Niitsuma, T | 1 |
| Izawa, J | 1 |
| Maruoka, N | 1 |
| Nukaga, M | 1 |
| Tsuji, A | 1 |
| Okita, M | 1 |
| Sakurai, K | 1 |
| Morita, S | 1 |
| Tsuyuguchi, M | 1 |
| Matsumura, Y | 2 |
| Hayashi, T | 1 |
| Yamauchi, K | 2 |
| Shinjo, Y | 1 |
| Niwa, T | 1 |
| Imoto, K | 1 |
| Koda, A | 1 |
| Matsui, T | 2 |
| Suzuki, K | 2 |
| Ueda, S | 1 |
| Ohno, T | 1 |
| Nakayama, K | 1 |
| Miyata, Y | 1 |
| Yukawa, E | 1 |
| Higuchi, S | 1 |
| Mizuta, Y | 1 |
| Watanabe, T | 2 |
| Iinuma, Y | 1 |
| Naito, S | 1 |
| Nitta, K | 1 |
| Guilpain, P | 1 |
| Pagnoux, C | 1 |
| Lhote, F | 1 |
| Mouthon, L | 1 |
| Guillevin, L | 1 |
| Kobayashi, K | 1 |
| Hayashi, N | 1 |
| Ohira, D | 1 |
| Nasu, T | 1 |
| Otake, Y | 1 |
| Hata, H | 1 |
| Steinke, JW | 1 |
| Culp, JA | 1 |
| Taki, F | 1 |
| Suzuki, R | 1 |
| Torii, K | 1 |
| Matsumoto, S | 2 |
| Taniguchi, H | 1 |
| Yamamoto, H | 1 |
| Nagata, M | 1 |
| Kuramitsu, K | 1 |
| Tabe, K | 1 |
| Kiuchi, H | 1 |
| Sakamoto, Y | 1 |
| Yamamoto, K | 1 |
| Dohi, Y | 1 |
| Taniguchi, Y | 1 |
| Tamura, G | 3 |
| Honma, M | 1 |
| Aizawa, T | 1 |
| Maruyama, N | 1 |
| Shirato, K | 1 |
| Takishima, T | 1 |
| Fujimura, M | 4 |
| Sakamoto, S | 1 |
| Kamio, Y | 3 |
| Matsuda, T | 3 |
| Misawa, M | 1 |
| Sugiyama, Y | 1 |
| Nakagawa, N | 2 |
| Obata, T | 2 |
| Kobayashi, T | 2 |
| Okada, Y | 4 |
| Nambu, F | 3 |
| Terawaki, T | 2 |
| Furuya, T | 1 |
| Muryobayashi, K | 1 |
| Sawada, M | 1 |
| Aishita, H | 2 |
| Brocks, DR | 2 |
| Upward, J | 1 |
| Hust, R | 1 |
| Köester, FE | 1 |
| Collie, H | 1 |
| Qian, Y | 1 |
| Dennis, MJ | 2 |
| Sakakibara, H | 1 |
| Hirose, K | 1 |
| Okawara, S | 1 |
| Yoshida, K | 1 |
| Mori, A | 1 |
| Sugiyama, H | 1 |
| Suko, M | 1 |
| Okudaira, H | 2 |
| Ito, K | 1 |
| Inokuma, S | 1 |
| Upward, JW | 1 |
| Georgiou, P | 1 |
| Stelman, G | 1 |
| Doyle, E | 1 |
| Allen, E | 1 |
| Wyld, P | 1 |
| Kagoshima, M | 2 |
| Tomomatsu, N | 2 |
| Iwahisa, Y | 2 |
| Kawakami, Y | 2 |
| Terasawa, M | 2 |
| Nishi, K | 1 |
| Watanabe, K | 2 |
| Ooka, T | 1 |
| Tamaoki, J | 1 |
| Kondo, M | 1 |
| Sakai, N | 1 |
| Nakata, J | 1 |
| Takemura, H | 1 |
| Nagai, A | 1 |
| Takizawa, T | 1 |
| Konno, K | 1 |
| Matsuura, M | 1 |
| Barnes, NC | 1 |
| Pujet, JC | 1 |
| Grossman, J | 1 |
| Faiferman, I | 2 |
| Dubb, JW | 1 |
| Tompson, DJ | 1 |
| Busse, W | 1 |
| Bronsky, E | 1 |
| Montanaro, A | 1 |
| Southern, L | 1 |
| Tinkelman, D | 1 |
| Oosaki, R | 1 |
| Mizushima, Y | 2 |
| Kashii, T | 1 |
| Kawasaki, A | 1 |
| Kobayashi, M | 1 |
| Drazen, JM | 2 |
| Yokoyama, A | 1 |
| Kohno, N | 1 |
| Sakai, K | 1 |
| Hirasawa, Y | 1 |
| Kondo, K | 1 |
| Hiwada, K | 1 |
| Tan, RA | 1 |
| Szefler, SJ | 1 |
| Hamilton, A | 1 |
| Stober, P | 1 |
| Watson, RM | 1 |
| Panettieri, RA | 1 |
| Tan, EM | 1 |
| Ciocca, V | 1 |
| Luttmann, MA | 1 |
| Leonard, TB | 1 |
| Hay, DW | 1 |
| Asai, S | 1 |
| Schurman, SJ | 1 |
| Alderman, JM | 1 |
| Massanari, M | 1 |
| Lacson, AG | 1 |
| Perlman, SA | 1 |
| Kasahara, J | 1 |
| Doi, M | 1 |
| Rosenwasser, LJ | 1 |
| Kinoshita, M | 1 |
| Shiraishi, T | 1 |
| Koga, T | 1 |
| Ayabe, M | 1 |
| Rikimaru, T | 1 |
| Oizumi, K | 1 |
| Hoshino, M | 1 |
| Sim, JJ | 1 |
| Ishii, K | 1 |
| Hosaka, K | 1 |
| Sakamoto, T | 1 |
| Tomita, K | 1 |
| Hashimoto, K | 2 |
| Nakamoto, N | 1 |
| Tokuyasu, H | 1 |
| Yamasaki, A | 1 |
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| Kawasaki, Y | 1 |
| Fukutani, K | 1 |
| Saito, T | 1 |
| Kurokawa, K | 1 |
| Teramoto, S | 1 |
| Miyazaki, N | 1 |
| Kaneko, S | 1 |
| Hashimoto, M | 2 |
| Abe, S | 2 |
| Arakida, Y | 3 |
| Ohga, K | 3 |
| Suwa, K | 3 |
| Yokota, M | 3 |
| Miyata, K | 2 |
| Yamada, T | 3 |
| Honda, K | 2 |
| Nakasato, H | 1 |
| Ohrui, T | 1 |
| Sekizawa, K | 1 |
| Yamaya, M | 1 |
| Sasaki, H | 1 |
| Kohrogi, H | 1 |
| Iwagoe, H | 1 |
| Fujii, K | 1 |
| Hamamoto, J | 1 |
| Fukuda, K | 1 |
| Hirata, N | 1 |
| Kawano, O | 1 |
| Matsumoto, M | 1 |
| Suga, M | 1 |
| Ando, M | 1 |
| Wechsler, ME | 1 |
| Pauwels, R | 1 |
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| Nakajima, S | 1 |
| Yamashita, K | 2 |
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| Abo, M | 2 |
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| Hashimoto, T | 2 |
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| Yoshida, S | 2 |
| Sakamoto, H | 1 |
| Ishizaki, Y | 2 |
| Onuma, K | 2 |
| Shoji, T | 2 |
| Nakagawa, H | 2 |
| Hasegawa, H | 2 |
| Nakabayashi, M | 2 |
| Amayasu, H | 2 |
| Ishioka, S | 2 |
| Hozawa, S | 2 |
| Haruta, Y | 2 |
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| Maeda, A | 2 |
| Yamakido, M | 2 |
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| Matsumoto, Y | 1 |
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| Pan, LH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fractional Concentration of Exhaled NO(FeNO) to Direct The Treatment of Sub-acute Cough：A Prospective, Open Label, Randomized and Placebo-Controlled Trial[NCT02655562] | Phase 4 | 200 participants (Anticipated) | Interventional | 2016-04-30 | Suspended (stopped due to There are difficulties in recruiting patients) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for ono 1078 and Asthma
| Article | Year |
|---|---|
Interventions for autumn exacerbations of asthma in children.
Topics: Acetates; Adrenal Cortex Hormones; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Behavior The | 2018 |
Leukotriene receptor antagonists pranlukast and montelukast for treating asthma.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Chromones; Cyclopropanes; Cysteine; Humans; Leukot | 2014 |
Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetates; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; A | 2014 |
Pranlukast: a review of its use in the management of asthma.
Topics: Adolescent; Adult; Aged; Animals; Anti-Asthmatic Agents; Asthma; Child; Chromones; Disease Models, A | 2003 |
Recent advances in the management of asthma using leukotriene modifiers.
Topics: Acetates; Administration, Inhalation; Adolescent; Adult; Asthma; Child; Child, Preschool; Chromones; | 2003 |
[Antileukotrienes and Churg-Strauss syndrome].
Topics: Acetates; Adult; Anti-Asthmatic Agents; Antibodies, Antineutrophil Cytoplasmic; Asthma; Chromones; C | 2007 |
Leukotriene synthesis inhibitors versus antagonists: the pros and cons.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Asthma; Chromones; Cyclopropa | 2007 |
[The brittle asthmatic and the morning dipper].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Chromones; Circad | 1996 |
[Peptidoleukotriene receptor antagonists in asthma therapy].
Topics: Asthma; Chromones; Humans; Indoles; Leukotriene Antagonists; Phenylcarbamates; Propionates; Quinolin | 1996 |
Challenge studies of a leukotriene receptor antagonist.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Provocation Tests; | 1997 |
New directions in asthma drug therapy.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chromones; Humans; Hydroxyur | 1998 |
The role of antileukotrienes in asthma management.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Ind | 1998 |
Zafirlukast: an update of its pharmacology and therapeutic efficacy in asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Anti-Asthmatic Agents; Asthma; Child | 2001 |
Antileukotrienes in asthma: present situation.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Chromones; Clinical Trials as Topic; | 2001 |
[Leukotriene modifiers].
Topics: Acetates; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; L | 2001 |
A brief review of preclinical and clinical studies with LY171883 and some comments on newer cysteinyl leukotriene receptor antagonists.
Topics: Acetophenones; Animals; Asthma; Azoles; Bronchi; Chromones; Dicarboxylic Acids; Drug Evaluation; Dru | 1988 |
38 trials available for ono 1078 and Asthma
| Article | Year |
|---|---|
Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Asthmatic Agents; Asthma; Chromones; D | 2016 |
Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic | 2008 |
Molecular mechanism of the additive effects of leukotriene modifier in asthmatic patients receiving steroid therapy.
Topics: Acetates; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Chemokine CCL5; Chromo | 2009 |
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig | 2009 |
Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation.
Topics: Administration, Oral; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Anti-Asth | 2012 |
Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection.
Topics: Adult; Anti-Asthmatic Agents; Antigens, Viral; Asthma; Chromones; Drug Combinations; Female; Humans; | 2012 |
Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein.
Topics: Adult; Aged; Analysis of Variance; Asthma; Beclomethasone; Benzoquinones; Blood Proteins; Chromones; | 2002 |
Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.
Topics: Administration, Inhalation; Adult; Albuterol; Analysis of Variance; Androstadienes; Anti-Asthmatic A | 2002 |
[Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma].
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Biomarkers; Blood Proteins; Chromones; D | 2003 |
The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma.
Topics: Adult; Antigens, CD34; Asthma; Basophils; Bone Marrow; Bronchial Provocation Tests; Chromones; Cross | 2004 |
Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Blood Proteins; Chromones; Double-Blind Method; Eosinophil Gra | 2004 |
Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma.
Topics: Adult; Allergens; Asthma; Bronchial Hyperreactivity; Cell Count; Chemotactic Factors; Chromones; Cro | 2004 |
Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Aged; Androstadienes; Anti-Asthmatic Agents; A | 2007 |
Inhibition of analgesic-induced asthma by leukotriene receptor antagonist ONO-1078.
Topics: Adult; Aged; Aspirin; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Chromones; Dipyrone; | 1994 |
The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects.
Topics: Administration, Oral; Adult; Allergens; Asthma; Bronchoconstriction; Capsules; Chromones; Double-Bli | 1993 |
Effect of a leukotriene antagonist, ONO-1078, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chromones; Double-Blind | 1993 |
The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers.
Topics: Adolescent; Adult; Asthma; Chromones; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Dr | 1996 |
Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. The Tokyo Joshi-Idai Asthma Research Group.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Beclomethasone; | 1997 |
Pranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Asthmatic Agents; Asthma; Chromones; D | 1997 |
Results of the first U.S. double-blind, placebo-controlled, multicenter clinical study in asthma with pranlukast, a novel leukotriene receptor antagonist.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Chromones; Double-Blind Method; Female; Forced Expiratory Volu | 1997 |
Therapeutic effect of pranlukast, a selective cysteinyl leukotriene receptor antagonist, on bronchial asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Asthma; Beclomethasone; Chromones; Fe | 1997 |
Effect of pranlukast, a leukotriene receptor antagonist, in patients with severe asthma refractory to corticosteroids.
Topics: Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Chromones; Female; Glucocorticoids; Humans; Leu | 1998 |
Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early- and late-phase bronchoconstriction and airway hyperresponsiveness in asthmatic subjects.
Topics: Adolescent; Adult; Allergens; Anti-Asthmatic Agents; Asthma; Bronchial Diseases; Chromones; Cross-Ov | 1998 |
Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma.
Topics: Administration, Oral; Adult; Anti-Asthmatic Agents; Antigens; Asthma; Benzoquinones; Blood Proteins; | 1998 |
Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma.
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Blood Proteins; Chromones; Eosinophil Granule Proteins; | 1999 |
Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma.
Topics: Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Antigens, CD; Asthma; Bronchi; Bronchial Pro | 1998 |
[Pranlukast allows reduction of inhaled steroid dose without deterioration in lung function in adult asthmatics].
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Case-Control Studi | 1999 |
Leukotriene (LT)-receptor antagonist is more effective in asthmatic patients with a low baseline ratio of urinary LTE4 to 2,3-dinor-6-keto-prostaglandin (PG)F1alpha.
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Chromones; Female; Humans; Leukotriene Antagonists; Leuk | 1999 |
Effect of leukotriene and thromboxane antagonist on propranolol-induced bronchoconstriction.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Asthma; Benzoquinones; Bronchoconstriction; Chromones; Dou | 1999 |
Decreased exhaled nitric oxide in mild persistent asthma patients treated with a leukotriene receptor antagonist, pranlukast.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Chromones; Female; Humans; Leukotriene Antagonists; Male; Midd | 1999 |
Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma.
Topics: Adult; Analgesics; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; | 2000 |
Effect of pranlukast on bronchial inflammation in patients with asthma.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchoconstricti | 2000 |
Effects of pranlukast, a leukotriene receptor antagonist, on airway inflammation in mild asthmatics.
Topics: Adult; Asthma; Chromones; Eosinophils; Female; Humans; Inflammation; Leukocyte Count; Leukotriene An | 2001 |
Clinical effects of pranlukast, an oral leukotriene receptor antagonist, in mild-to-moderate asthma: a 4 week randomized multicentre controlled trial.
Topics: Adrenergic beta-Agonists; Adult; Aged; Analysis of Variance; Asthma; Chromones; Consumer Product Saf | 2001 |
Efficacy and safety of long-term treatment of asthmatic patients with pranlukast, a cysteinyl-leukotriene-receptor antagonist: four-year followup study.
Topics: Adult; Aged; Asthma; Chromones; Diarrhea; Female; Humans; Male; Middle Aged; Peak Expiratory Flow Ra | 2001 |
Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients.
Topics: Acetaldehyde; Adult; Asthma; Bronchoconstriction; Chromones; Cross-Over Studies; Cysteine; Double-Bl | 2001 |
Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma.
Topics: Administration, Inhalation; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Beclomethasone; | 2001 |
Effect of leukotriene antagonist on experimental and clinical bronchial asthma.
Topics: Allergens; Anaphylaxis; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Chromones; Drug Evalu | 1991 |
60 other studies available for ono 1078 and Asthma
| Article | Year |
|---|---|
Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.
Topics: Animals; Asthma; Biological Availability; Butyrates; Dogs; Guinea Pigs; Humans; Indoles; Leukotriene | 2015 |
The leukotriene receptor antagonist pranlukast attenuates airway remodeling by suppressing TGF-β signaling.
Topics: Airway Remodeling; Animals; Asthma; Cell Line; Chromones; Collagen; Disease Models, Animal; Female; | 2018 |
Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner.
Topics: Adrenal Cortex Hormones; Analysis of Variance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell C | 2014 |
Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics.
Topics: Alleles; Anti-Asthmatic Agents; Asian People; Asthma; Chromones; Female; Forced Expiratory Volume; G | 2009 |
Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchial Hyperreactivity; Chro | 2010 |
Successful multidrug treatment of a pediatric patient with severe Churg-Strauss syndrome refractory to prednisolone.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Child; Chromones; Churg-Strauss Syndrome; C | 2011 |
Correlation between cysteinyl leukotriene release from leukocytes and clinical response to a leukotriene inhibitor.
Topics: Adolescent; Adult; Asthma; Chromones; Cysteine; Female; Humans; Inflammation Mediators; Leukocytes; | 2002 |
Evaluation of the combined effect of pranlukast during high-dose steroid inhalation.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Anti-Inflammatory Ag | 2002 |
Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; | 2003 |
Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics.
Topics: Adult; Allergens; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Cells, Cultured; Chromones | 2003 |
Churg-Strauss syndrome may be induced by leukotriene modifiers in severe asthma.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Chromones; Churg-Strauss Syndrome; Eosinophilia; Humans; Leu | 2003 |
Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchitis; Chemokine CCL5; | 2003 |
The Churg-Strauss syndrome after pranlukast treatment in a patient not receiving corticosteroids.
Topics: Aged; Anti-Asthmatic Agents; Asthma; Chromones; Churg-Strauss Syndrome; Female; Humans; Leukotriene | 2003 |
Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Aged; Anti-Asthmatic Agents; Asthma; | 2003 |
Churg-Strauss syndrome (CSS) in a patient receiving pranlukast.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Chromones; Churg-Strauss Syndrome; Cyclophosphamide; Do | 2003 |
Long-term follow-up of pulmonary function in bronchial asthma patients treated with pranlukast.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Chromones; Dose- | 2004 |
Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast.
Topics: Anti-Asthmatic Agents; Asthma; Chromones; Churg-Strauss Syndrome; Humans; Leukotriene Antagonists; R | 2005 |
Clinical evaluation of response to long-term treatment with Pranlukast in patients with bronchial asthma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Asthma; Chromones; Circadian Rhythm; Fe | 2004 |
Delayed-type asthmatic response induced by repeated intratracheal exposure to toluene-2,4-diisocyanate in guinea pigs.
Topics: Airway Resistance; Albumins; Albuterol; Allergens; Animals; Asthma; Chromones; Dexamethasone; Diseas | 2005 |
Effect of pet removal on pet allergic asthma.
Topics: Adult; Animals; Animals, Domestic; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Chrom | 2005 |
Effects of various anti-asthmatic agents on mite allergen-pulsed murine bone marrow-derived dendritic cells.
Topics: Albuterol; Androstadienes; Animals; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Asthma; Bone | 2005 |
Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.
Topics: Adolescent; Algorithms; Anti-Asthmatic Agents; Asthma; Child; Child, Preschool; Chromones; Data Inte | 2006 |
Effects of anti-inflammatory therapies on recurrent and low-grade respiratory syncytial virus infections in a murine model of asthma.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Asthma; Bronchoalveola | 2006 |
Eosinophilic tumor in a patient with bronchial asthma receiving pranlukast.
Topics: Anti-Asthmatic Agents; Asthma; Biopsy; Child; Chromones; Diagnosis, Differential; Eosinophilic Granu | 2007 |
Reduction of the severity of bronchial hyperresponsiveness by the novel leukotriene antagonist 4-oxo-8-[4-(4-phenyl-butoxy)benzoylamino]-2- (tetrazol-5-yl)-4H-1-benzopyran hemihydrate.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Chromones; Female; Forced Expirator | 1994 |
An airway hyperresponsiveness model in rat allergic asthma.
Topics: Acetylcholine; Animals; Ascaris; Asthma; Bronchial Hyperreactivity; Capillary Permeability; Chromone | 1993 |
Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma.
Topics: Acetylcholine; Acute-Phase Reaction; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrict | 1993 |
The pharmacokinetics of pranlukast in healthy young and elderly subjects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Asthma; Chromones; Female; Humans | 1996 |
[Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils].
Topics: Asthma; Blood Proteins; Cells, Cultured; Chromones; Depression, Chemical; Eosinophil Granule Protein | 1996 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; D | 1997 |
[Cough-variant asthma successfully treated with a peptide leukotriene receptor antagonist].
Topics: Anti-Asthmatic Agents; Asthma; Chromones; Cough; Female; Humans; Leukotriene Antagonists; Middle Age | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepin | 1997 |
Leukotriene modifiers: what is their position in asthma therapy?
Topics: Anti-Asthmatic Agents; Asthma; Chromones; Humans; Leukotriene Antagonists | 1998 |
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists.
Topics: Asthma; Carbachol; Cells, Cultured; Chromones; Dicarboxylic Acids; DNA Replication; Epidermal Growth | 1998 |
Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.
Topics: Acute Disease; Asthma; Biopsy; Child; Chromones; Creatinine; Follow-Up Studies; Glycosuria; Hematuri | 1998 |
Leukotriene modifiers: new drugs, old and new reactions.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Autoimmune Diseases; Chromones; Churg-Strauss Syndrome; Cyc | 1999 |
Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast.
Topics: Anti-Asthmatic Agents; Asthma; Chromones; Churg-Strauss Syndrome; Female; Humans; Leukotriene Antago | 1999 |
Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs.
Topics: Administration, Oral; Animals; Asthma; Chromones; Disease Models, Animal; Guinea Pigs; Immunization, | 1999 |
Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist.
Topics: Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Chromones; Cytokines; Female; Histamine; Humans; L | 1999 |
The role of cysteinyl leukotrienes in the pathogenesis of asthma: clinical study of leukotriene antagonist pranlukast for 1 year in moderate and severe asthma.
Topics: Adult; Aged; Asthma; Chromones; Female; Humans; Leukotriene Antagonists; Male; Middle Aged; Peak Exp | 1999 |
Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal?
Topics: Acetates; Adrenal Cortex Hormones; Asthma; Chromones; Churg-Strauss Syndrome; Cyclopropanes; Eosinop | 1999 |
Effects of ONO-1078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma.
Topics: Adult; Animals; Asthma; Chromones; Cytokines; Female; Humans; Hypersensitivity; Leukocytes, Mononucl | 1999 |
Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs.
Topics: Administration, Inhalation; Airway Obstruction; Aluminum Hydroxide; Animals; Antigens; Asthma; Benzo | 1999 |
Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic protein levels in patients with asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Anti-Asthmatic Agents; Asthma; Blood Proteins; Ch | 1999 |
Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Benzoquinones; B | 2000 |
[Churg-Strauss syndrome during corticosteroid tapering in a patient with bronchial asthma receiving pranlukast].
Topics: Anti-Asthmatic Agents; Asthma; Chromones; Churg-Strauss Syndrome; Female; Humans; Leukotriene Antago | 2000 |
Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aspirin; Asthma; Bronchial Hyperreactivity; Chromones; Drug To | 2000 |
Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, N | 2000 |
Churg-Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma.
Topics: Administration, Inhalation; Administration, Topical; Anti-Asthmatic Agents; Anti-Inflammatory Agents | 2001 |
Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients.
Topics: Adult; Aspirin; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchoconstriction; Chromones | 2001 |
Fulminant eosinophilic endomyocarditis in an asthmatic patient treated with pranlukast after corticosteroid withdrawal.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Biopsy; Chromones; Eosinophilia; Female; Humans; Myocarditis; | 2001 |
Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.
Topics: Acute Disease; Anti-Asthmatic Agents; Asthma; Chromones; Diagnosis, Differential; Female; Humans; Le | 2001 |
Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.
Topics: Adult; Anti-Asthmatic Agents; Aspirin; Asthma; Blood Proteins; Bronchial Provocation Tests; Chromone | 2002 |
Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Topics: Animals; Asthma; Cell Survival; Chromones; Cysteine; Eosinophilia; Guinea Pigs; Interleukin-5; Kinet | 2002 |
[The effectiveness of the long-term treatment with pranlukast in pediatric patients with mild to moderate asthma].
Topics: Adolescent; Anti-Asthmatic Agents; Asthma; Child; Child, Preschool; Chromones; Female; Humans; Infan | 2002 |
[Evaluation before and after pranlukast administration with the QOL questionnaire (revised version 2001) for pediatric patients with bronchial asthma and their parents or caregivers].
Topics: Anti-Asthmatic Agents; Asthma; Child, Preschool; Chromones; Female; Humans; Leukotriene Antagonists; | 2002 |
In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Binding, Competitive; Chromones; Guinea Pigs; In Vitro | 1992 |
[Bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 (LTC4) and LTD4 in guinea pigs].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Chromones; Guinea Pigs; Hist | 1992 |
Inhibition of endogenous leukotriene-mediated lung anaphylaxis in guinea pigs by a novel receptor antagonist ONO-1078.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Chromones; Guinea Pigs; Lung; Male; Muscle Contra | 1990 |
[Eicosanoids in bronchial asthma].
Topics: Acrylates; Arachidonic Acids; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Chromones; Cycloo | 1990 |