ondansetron has been researched along with Torsade de Pointes in 11 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary objective of this retrospective safety study was to determine the incidence of torsades de pointes (TdP) or death following perioperative administration of low-dose, 4 mg, ondansetron for postoperative nausea and vomiting." | 5.51 | The incidence of torsades de pointes with peri-operative low-dose ondansetron administration. ( Ackerman, MJ; Danke, H; Marienau, MS; Nuttall, GA; Oyen, LJ; Voogd, SC; Warner, PA, 2022) |
| "We report a case of nearly fatal ventricular tachyarrhythmia type Torsade de pointes caused by medication-induced prolongation of QTc duration (methadone, ondansetron, escitalopram)." | 3.79 | [Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures]. ( Flury, G; Neumeier, C; Thaler, S, 2013) |
| "Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization." | 2.80 | Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study. ( Owczuk, R; Tracz, K, 2015) |
| "Ondansetron is a commonly used antiemetic in the emergency department despite a 2011 FDA warning regarding dose-related QTc prolongation and torsades des pointes (TdP)." | 1.91 | QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron. ( Cole, JB; Fuchs, RT; Fushianes, GD; Lee, SC; Orozco, BS, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Nuttall, GA | 1 |
| Voogd, SC | 1 |
| Danke, H | 1 |
| Warner, PA | 1 |
| Oyen, LJ | 1 |
| Marienau, MS | 1 |
| Ackerman, MJ | 1 |
| Orozco, BS | 1 |
| Lee, SC | 1 |
| Fuchs, RT | 1 |
| Fushianes, GD | 1 |
| Cole, JB | 1 |
| Al-Khalil, M | 1 |
| Sack, A | 1 |
| Elson, R | 1 |
| Pleat, J | 1 |
| De Puy, F | 1 |
| Kay, GN | 1 |
| Lee, DY | 1 |
| Trinh, T | 1 |
| Roy, SK | 1 |
| Thaler, S | 1 |
| Neumeier, C | 1 |
| Flury, G | 1 |
| Koren, G | 1 |
| Tracz, K | 1 |
| Owczuk, R | 1 |
| Merli, GJ | 1 |
| Weitz, HH | 1 |
| Mehta, D | 1 |
| Sanatani, S | 1 |
| Whyte, SD | 1 |
1 review available for ondansetron and Torsade de Pointes
| Article | Year |
|---|---|
Web Exclusives. The consult guys - twisted after surgery: what caused torsades?
Topics: Antiemetics; Craniotomy; Electrocardiography; Female; Humans; Hypotension; Intracranial Aneurysm; Mi | 2015 |
3 trials available for ondansetron and Torsade de Pointes
| Article | Year |
|---|---|
The incidence of torsades de pointes with peri-operative low-dose ondansetron administration.
Topics: Antiemetics; DNA-Binding Proteins; Humans; Incidence; Ondansetron; Postoperative Nausea and Vomiting | 2022 |
Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Topics: Adolescent; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; E | 2015 |
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Topics: Ambulatory Surgical Procedures; Antiemetics; Child, Preschool; Droperidol; Electrocardiography; Fema | 2010 |
7 other studies available for ondansetron and Torsade de Pointes
| Article | Year |
|---|---|
QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron.
Topics: Adult; Antiemetics; DNA-Binding Proteins; Electrocardiography; Female; Heart Arrest; Humans; Long QT | 2023 |
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int | 2020 |
Electrocardiogram Challenge Syncope in a Woman With Nausea and Diarrhea.
Topics: Aged; Cholecalciferol; Clonazepam; Diarrhea; Esomeprazole; Female; Fluconazole; Humans; Nausea; Onda | 2017 |
Torsades de Pointes after Ondansetron Infusion in 2 Patients.
Topics: Electrocardiography; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Ondansetron; Seroton | 2017 |
[Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures].
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopr | 2013 |
Treating morning sickness in the United States--changes in prescribing are needed.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Heart Defects, Conge | 2014 |
In brief: intravenous ondanstron (Zofran) 32 mg withdrawn.
Topics: Antiemetics; Antineoplastic Agents; Humans; Long QT Syndrome; Nausea; Ondansetron; Product Recalls a | 2012 |