ondansetron has been researched along with Sensitivity and Specificity in 18 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The oral bioavailability of ondansetron averaged 67 per cent and the elimination half-life after oral administration was 5." | 2.69 | Pharmacokinetics and bioavailability studies of generic ondansetron, and the innovator preparation, in healthy Thai male volunteers. ( Apisariyakul, A; Kumsorn, B; Manorot, M; Nawoot, S; Rojanasthien, N; Sangdee, C; Teekachunhatean, S, 1999) |
| " The analytical method was applied to evaluate the relative bioavailability of two pharmaceutical formulations containing 8 mg of ondansetron each in 25 healthy volunteers using a randomized, two-period crossover design." | 1.36 | Development and validation of a rapid and sensitive LC-ESI-MS/MS method for ondansetron quantification in human plasma and its application in comparative bioavailability study. ( Azevedo, CP; Borges, DC; Borges, NC; Moreira, RF; Moreno, RA; Oliveira-Silva, D; Salvadori, MC; Sverdloff, CE, 2010) |
| "Pyrimethamine was used as the internal standard." | 1.31 | Determination of ondansetron and its hydroxy metabolites in human serum using solid-phase extraction and liquid chromatography/positive ion electrospray tandem mass spectrometry. ( Bartlett, MG; Stewart, JT; Xu, X, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 2 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 2 |
| He, Z | 1 |
| Huang, C | 1 |
| Wan, H | 1 |
| Zhang, J | 1 |
| Zhong, H | 1 |
| Li, J | 1 |
| Wang, Q | 1 |
| Zhang, H | 1 |
| Duan, M | 1 |
| Zhao, Q | 1 |
| Zhong, D | 2 |
| Yuan, Y | 1 |
| Arellano, C | 1 |
| Gandia, P | 1 |
| Bettuing, L | 1 |
| Woodley, J | 1 |
| Chatelut, E | 1 |
| Moreira, RF | 1 |
| Salvadori, MC | 1 |
| Azevedo, CP | 1 |
| Oliveira-Silva, D | 1 |
| Borges, DC | 1 |
| Moreno, RA | 1 |
| Sverdloff, CE | 1 |
| Borges, NC | 1 |
| Alvarez, JC | 1 |
| Charbit, B | 1 |
| Grassin-Delyle, S | 1 |
| Demolis, JL | 1 |
| Funck-Brentano, C | 1 |
| Abe, E | 1 |
| Dotsikas, Y | 1 |
| Kousoulos, C | 1 |
| Tsatsou, G | 1 |
| Loukas, YL | 1 |
| Liu, K | 1 |
| Dai, X | 1 |
| Chen, X | 1 |
| Rubenstein, EB | 1 |
| Elting, LS | 1 |
| Ng, CL | 1 |
| Ong, CP | 1 |
| Lee, HK | 1 |
| Li, SF | 1 |
| Wring, SA | 1 |
| Rooney, RM | 1 |
| Goddard, CP | 1 |
| Waterhouse, I | 1 |
| Jenner, WN | 1 |
| Brown, NJ | 1 |
| Horton, A | 1 |
| Rumsey, RD | 1 |
| Read, NW | 1 |
| Siluveru, M | 1 |
| Stewart, JT | 3 |
| Dépôt, M | 1 |
| Leroux, S | 1 |
| Caillé, G | 1 |
| Rojanasthien, N | 1 |
| Manorot, M | 1 |
| Kumsorn, B | 1 |
| Nawoot, S | 1 |
| Teekachunhatean, S | 1 |
| Sangdee, C | 1 |
| Apisariyakul, A | 1 |
| Xu, X | 1 |
| Bartlett, MG | 1 |
| Bauer, S | 1 |
| Störmer, E | 1 |
| Kaiser, R | 1 |
| Tremblay, PB | 1 |
| Brockmöller, J | 1 |
| Roots, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Drug Monitoring of Corticosteroids/β2-agonists in Hair in Asthmatic Patients: an Open-label Feasibility Study[NCT03691961] | 24 participants (Actual) | Interventional | 2018-09-20 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ondansetron and Sensitivity and Specificity
| Article | Year |
|---|---|
Pharmacokinetics and bioavailability studies of generic ondansetron, and the innovator preparation, in healthy Thai male volunteers.
Topics: Adolescent; Adult; Antiemetics; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical | 1999 |
17 other studies available for ondansetron and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Quantification of ondansetron, granisetron and tropisetron in goat plasma using hydrophilic interaction liquid chromatography-solid phase extraction coupled with hydrophilic interaction liquid chromatography-triple quadrupole tandem mass spectrometry.
Topics: Acetonitriles; Animals; Chromatography, Liquid; Formates; Goats; Granisetron; Hydrophobic and Hydrop | 2018 |
Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method.
Topics: Animals; Chromatography, Liquid; Female; Linear Models; Male; Ondansetron; Random Allocation; Rats; | 2019 |
Quantification of topotecan by liquid chromatography-mass spectrometry (LC-MS). Application to intestinal transport using rat everted gut sacs.
Topics: Animals; Antiemetics; Antineoplastic Agents; Chromatography, Liquid; Drug Interactions; Duodenum; Hy | 2010 |
Development and validation of a rapid and sensitive LC-ESI-MS/MS method for ondansetron quantification in human plasma and its application in comparative bioavailability study.
Topics: Adolescent; Adult; Biological Availability; Chromatography, Liquid; Female; Humans; Male; Middle Age | 2010 |
Human plasma quantification of droperidol and ondansetron used in preventing postoperative nausea and vomiting with a LC/ESI/MS/MS method.
Topics: Chromatography, Liquid; Droperidol; Humans; Linear Models; Ondansetron; Postoperative Nausea and Vom | 2011 |
Development and validation of a rapid 96-well format based liquid-liquid extraction and liquid chromatography-tandem mass spectrometry analysis method for ondansetron in human plasma.
Topics: Chromatography, Liquid; Humans; Ondansetron; Reproducibility of Results; Sensitivity and Specificity | 2006 |
Quantitative determination of ondansetron in human plasma by enantioselective liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Ondansetron; Reproducibility of | 2008 |
Re-examination of clinical aspects of pharmacoeconomic analysis.
Topics: Antineoplastic Agents; Economics, Pharmaceutical; Humans; Metoclopramide; Ondansetron; Pharmacology, | 1994 |
Determination of pharmaceuticals and related impurities by capillary electrophoresis.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Alkenes; beta-Cyclodextrins; Capillary Action; Chromatography, Hi | 1994 |
A sensitive radioimmunoassay, combined with solid-phase extraction, for the sub-nanogram per ml determination of ondansetron in human plasma.
Topics: Animals; Antibody Specificity; Calibration; Chromatography, High Pressure Liquid; Cross Reactions; H | 1994 |
Granisetron and ondansetron: effects on the ileal brake mechanism in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Transit; Granisetron; Ileum; Indazoles; | 1993 |
Enantioselective determination of S-(+)- and R-(-)-ondansetron in human serum using derivatized cyclodextrin-modified capillary electrophoresis and solid-phase extraction.
Topics: Antiemetics; Cyclodextrins; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Linear M | 1997 |
High-resolution liquid chromatographic method using ultraviolet detection for determination of ondansetron in human plasma.
Topics: Antiemetics; Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Ondansetron; Sensit | 1997 |
High-performance liquid chromatographic analysis of ondansetron enantiomers in human serum using a reversed-phase cellulose-based chiral stationary phase and solid-phase extraction.
Topics: Antiemetics; Chromatography, High Pressure Liquid; Humans; Ondansetron; Receptors, Serotonin; Recept | 1997 |
Determination of ondansetron and its hydroxy metabolites in human serum using solid-phase extraction and liquid chromatography/positive ion electrospray tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Molecular Structure; Ondansetron; Pyrimethamine; Reprod | 2000 |
Simultaneous determination of ondansetron and tropisetron in human plasma using HPLC with UV detection.
Topics: Chromatography, High Pressure Liquid; Humans; Indoles; Ondansetron; Reference Standards; Reproducibi | 2002 |