Compounds > ondansetron
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ondansetron and Renal Insufficiency

ondansetron has been researched along with Renal Insufficiency in 4 studies

Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Research Excerpts

ExcerptRelevanceReference
"Elevated plasma histamine levels are considered to play a part in the pathophysiology of hemodialysis-related pruritus."9.10Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. ( Domröse, U; Dunker, N; Gollnick, H; Neumann, KH; Weisshaar, E, 2003)
"Elevated plasma histamine levels are considered to play a part in the pathophysiology of hemodialysis-related pruritus."5.10Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. ( Domröse, U; Dunker, N; Gollnick, H; Neumann, KH; Weisshaar, E, 2003)
"Pruritus is the most distressing symptom in haemodialysis (HD) patients."2.71Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients. ( Dunker, N; Gollnick, H; Röhl, FW; Weisshaar, E, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Weisshaar, E2
Dunker, N2
Domröse, U1
Neumann, KH1
Gollnick, H2
Röhl, FW1
Luz, C1
Souza, A1
Reis, R1
Fregoneze, JB1
de Castro e Silva, E1
Childs, AM1
Coates, AS1
Cox, KM1
Mainwaring, PN1

Trials

2 trials available for ondansetron and Renal Insufficiency

ArticleYear
Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy.
    Clinical nephrology, 2003, Volume: 59, Issue:2

    Topics: Adult; Cetirizine; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Indoles; Male;

2003
Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients.
    Experimental dermatology, 2004, Volume: 13, Issue:5

    Topics: Adult; Aged; Antipruritics; Cetirizine; Female; Histamine; Histamine H1 Antagonists; Humans; Indoles

2004

Other Studies

2 other studies available for ondansetron and Renal Insufficiency

ArticleYear
Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats.
    Brain research, 2006, Jul-12, Volume: 1099, Issue:1

    Topics: Amygdala; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Biguanides; Dose-Resp

2006
Severe vascular adverse effects with thrombocytopenia and renal failure following emetogenic chemotherapy and ondansetron.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1994, Volume: 5, Issue:1

    Topics: Adult; Antineoplastic Agents; Emetics; Female; Humans; Male; Ondansetron; Renal Insufficiency; Throm

1994