ondansetron has been researched along with Parkinson Disease in 11 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This systematic review identified published studies that evaluated the use of ondansetron in individuals with psychosis associated with dementia." | 8.98 | Is ondansetron beneficial for psychosis associated with dementia?. ( Farheen, SA; Lingamchetty, T; Maksimowski, M; Tampi, RR, 2018) |
| "This systematic review identified published studies that evaluated the use of ondansetron in individuals with psychosis associated with dementia." | 4.98 | Is ondansetron beneficial for psychosis associated with dementia?. ( Farheen, SA; Lingamchetty, T; Maksimowski, M; Tampi, RR, 2018) |
| " In the prelevodopa era, depression and other psychiatric disorders were described in PD, but in untreated patients psychosis was rare." | 4.79 | Parkinson's disease: drug-induced psychiatric states. ( Brown, D; Factor, SA; Molho, ES; Podskalny, GD, 1995) |
| "Ondansetron did not cause any worsening in basic PD symptoms or levodopa efficacy and was well tolerated with no major side effects." | 2.68 | Psychosis in advanced Parkinson's disease: treatment with ondansetron, a 5-HT3 receptor antagonist. ( Friedberg, G; Livneh, M; Melamed, E; Zoldan, J, 1995) |
| "Psychotic symptoms in Parkinson's disease (PD) are relatively common and, in addition to creating a disturbance in patients' daily lives, have consistently been shown to be associated with poor outcome." | 2.44 | Pathophysiology and treatment of psychosis in Parkinson's disease: a review. ( Fernandez, HH; Zahodne, LB, 2008) |
| "We hypothesized that hyperalgesia of 6-OHDA rats may be related to increased excitability of SDH neurons, and functional change of 5-HT3 receptor may reverse the hyperalgesia of 6-OHDA lesioned rats and decrease cell excitability of SDH neurons." | 1.72 | Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Li, CJ | 1 |
| Zhang, LG | 1 |
| Liu, LB | 1 |
| An, MQ | 1 |
| Dong, LG | 1 |
| Gu, HY | 1 |
| Dai, YP | 1 |
| Wang, F | 1 |
| Mao, CJ | 1 |
| Liu, CF | 1 |
| Kwan, C | 1 |
| Huot, P | 1 |
| Schoen, NB | 1 |
| Jermakowicz, WJ | 1 |
| Luca, CC | 1 |
| Jagid, JR | 1 |
| Tampi, RR | 1 |
| Maksimowski, M | 1 |
| Lingamchetty, T | 1 |
| Farheen, SA | 1 |
| Simonetto, M | 1 |
| Ferigo, L | 1 |
| Zanet, L | 1 |
| Capus, L | 1 |
| Antonutti, L | 1 |
| Zorzon, M | 1 |
| Pizzolato, G | 1 |
| Zahodne, LB | 1 |
| Fernandez, HH | 1 |
| Rasimas, JJ | 1 |
| Zoldan, J | 3 |
| Friedberg, G | 3 |
| Livneh, M | 1 |
| Melamed, E | 3 |
| Factor, SA | 1 |
| Molho, ES | 1 |
| Podskalny, GD | 1 |
| Brown, D | 1 |
| Goldberg-Stern, H | 1 |
| Weizman, A | 1 |
3 reviews available for ondansetron and Parkinson Disease
| Article | Year |
|---|---|
Is ondansetron beneficial for psychosis associated with dementia?.
Topics: Antipsychotic Agents; Cognition Disorders; Dementia; Humans; Ondansetron; Parkinson Disease; Psychot | 2018 |
Pathophysiology and treatment of psychosis in Parkinson's disease: a review.
Topics: Antidepressive Agents; Antipsychotic Agents; Cholinesterase Inhibitors; Clinical Trials as Topic; El | 2008 |
Parkinson's disease: drug-induced psychiatric states.
Topics: Aged; Anxiety; Bipolar Disorder; Clozapine; Depression; Electroconvulsive Therapy; Humans; Levodopa; | 1995 |
3 trials available for ondansetron and Parkinson Disease
| Article | Year |
|---|---|
Psychosis in advanced Parkinson's disease: treatment with ondansetron, a 5-HT3 receptor antagonist.
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Ondansetron; Parkinson Disease; Psychose | 1995 |
Ondansetron for hallucinosis in advanced Parkinson's disease.
Topics: Aged; Female; Hallucinations; Humans; Male; Middle Aged; Ondansetron; Parkinson Disease | 1993 |
Ondansetron, a 5-HT3 antagonist for visual hallucinations and paranoid delusional disorder associated with chronic L-DOPA therapy in advanced Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Delusions; Female; Hallucinations; Humans; Levodopa; | 1996 |
5 other studies available for ondansetron and Parkinson Disease
| Article | Year |
|---|---|
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P | 2022 |
5-HT
Topics: Antipsychotic Agents; Humans; Ondansetron; Parkinson Disease; Psychotic Disorders; Receptors, Seroto | 2019 |
Acute symptomatic peri-lead edema 33 hours after deep brain stimulation surgery: a case report.
Topics: Anti-Inflammatory Agents; Brain Edema; Deep Brain Stimulation; Dexamethasone; Headache; Humans; Male | 2017 |
Acute Akinesia, an unusual complication in Parkinson's Disease: a case report.
Topics: Acute Disease; Aged; Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Creatine Kinase; Dis | 2008 |
Treatment of psychosis in Lewy body disease.
Topics: Comorbidity; Electroconvulsive Therapy; Humans; Lewy Body Disease; Ondansetron; Parkinson Disease; P | 2008 |