ondansetron has been researched along with Neuroblastoma in 12 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 1-year-old girl with stage-IV neuroblastoma developed ondansetron hydrochloride anaphylaxis." | 7.76 | Anaphylactic reaction owing to ondansetron administration in a child with neuroblastoma and safe use of granisetron: a case report. ( Batu, ED; Büyükpamukçu, M; Civelek, E; Demir, HA; Saçkesen, C; Yalçın, B, 2010) |
| "The pharmacological characteristics of 5-HT3 receptor (5-hydroxytryptamine3 receptor) recognition sites labelled with [3H]-(S)-zacopride and [3H]granisetron in membranes prepared from NG108-15 neuroblastoma-glioma cells were directly compared to investigate further differences in the binding characteristics of these two radioligands." | 7.68 | Differential binding characteristics of agonists at 5-HT3 receptor recognition sites in NG108-15 neuroblastoma-glioma cells labelled by [3H]-(S)-zacopride and [3H]granisetron. ( Barnes, JM; Barnes, NM, 1993) |
| "A 1-year-old girl with stage-IV neuroblastoma developed ondansetron hydrochloride anaphylaxis." | 3.76 | Anaphylactic reaction owing to ondansetron administration in a child with neuroblastoma and safe use of granisetron: a case report. ( Batu, ED; Büyükpamukçu, M; Civelek, E; Demir, HA; Saçkesen, C; Yalçın, B, 2010) |
| "The pharmacological characteristics of 5-HT3 receptor (5-hydroxytryptamine3 receptor) recognition sites labelled with [3H]-(S)-zacopride and [3H]granisetron in membranes prepared from NG108-15 neuroblastoma-glioma cells were directly compared to investigate further differences in the binding characteristics of these two radioligands." | 3.68 | Differential binding characteristics of agonists at 5-HT3 receptor recognition sites in NG108-15 neuroblastoma-glioma cells labelled by [3H]-(S)-zacopride and [3H]granisetron. ( Barnes, JM; Barnes, NM, 1993) |
| "The effect of a novel 5-HT3 receptor antagonist, BRL 46470, has been studied on two electrophysiological models for 5-HT3 receptors: grease-gap recordings from rat isolated vagus nerve and whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma NG108-15 cells." | 3.68 | BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors. ( Blackburn, TP; Grahame-Smith, DG; Leslie, RA; Newberry, NR; Sprosen, TS; Watkins, CJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosen, T | 1 |
| Seeger, TF | 1 |
| McLean, S | 1 |
| Nagel, AA | 1 |
| Ives, JL | 1 |
| Guarino, KJ | 1 |
| Bryce, D | 1 |
| Furman, J | 1 |
| Roth, RW | 1 |
| Chalabi, PM | 1 |
| Carroll, C | 1 |
| Clinton, F | 1 |
| Smith, A | 1 |
| Fox, A | 1 |
| Capra, M | 1 |
| Pears, J | 1 |
| Owens, C | 1 |
| Demir, HA | 1 |
| Batu, ED | 1 |
| Yalçın, B | 1 |
| Civelek, E | 1 |
| Saçkesen, C | 1 |
| Büyükpamukçu, M | 1 |
| Stewart, A | 1 |
| Davies, PA | 1 |
| Kirkness, EF | 1 |
| Safa, P | 1 |
| Hales, TG | 1 |
| Morain, P | 1 |
| Abraham, C | 1 |
| Lacoste, JM | 1 |
| Malen, C | 1 |
| Laubie, M | 1 |
| Giesen-Crouse, E | 1 |
| Barnes, JM | 1 |
| Barnes, NM | 1 |
| Newberry, NR | 1 |
| Watkins, CJ | 1 |
| Sprosen, TS | 1 |
| Blackburn, TP | 1 |
| Grahame-Smith, DG | 1 |
| Leslie, RA | 1 |
| Toral, J | 1 |
| Hu, W | 1 |
| Critchett, D | 1 |
| Solomon, AJ | 1 |
| Barrett, JE | 1 |
| Sokol, PT | 1 |
| Ziai, MR | 1 |
| Arango, HA | 1 |
| Kalter, CS | 1 |
| Decesare, SL | 1 |
| Fiorica, JV | 1 |
| Lyman, GH | 1 |
| Spellacy, WN | 1 |
| Barann, M | 1 |
| Göthert, M | 1 |
| Brüss, M | 1 |
| Bönisch, H | 1 |
| Peters, JA | 2 |
| Malone, HM | 2 |
| Lambert, JJ | 2 |
1 review available for ondansetron and Neuroblastoma
| Article | Year |
|---|---|
Management of chemotherapy in a pregnancy complicated by a large neuroblastoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Female; Filgrastim; Gra | 1994 |
11 other studies available for ondansetron and Neuroblastoma
| Article | Year |
|---|---|
Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.
Topics: Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry; Glioma; Imidazoles; Mice; Molecu | 1990 |
Revised antiemetics guidelines and the impact on nutritional status during induction chemotherapy in children with high-risk neuroblastoma.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dexamethasone; | 2018 |
Anaphylactic reaction owing to ondansetron administration in a child with neuroblastoma and safe use of granisetron: a case report.
Topics: Anaphylaxis; Antiemetics; Antineoplastic Agents; Brain Neoplasms; Female; Granisetron; Humans; Infan | 2010 |
Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.
Topics: Animals; Biguanides; Calcium; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Dru | 2003 |
The antagonist properties of S 11978 on 5HT3 receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Binding, Competitive; Electrophysiology; Indoles; Kinetics; Mice; Neuroblastoma; Ondansetro | 1993 |
Differential binding characteristics of agonists at 5-HT3 receptor recognition sites in NG108-15 neuroblastoma-glioma cells labelled by [3H]-(S)-zacopride and [3H]granisetron.
Topics: Animals; Benzamides; Biguanides; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bri | 1993 |
BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; Glio | 1993 |
5-HT3 receptor-independent inhibition of the depolarization-induced 86Rb efflux from human neuroblastoma cells, TE671, by ondansetron.
Topics: Anti-Anxiety Agents; Benzamides; Benzofurans; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; H | 1995 |
Inhibition by steroids of [14C]-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells.
Topics: Animals; Carbon Radioisotopes; Cations; Dexamethasone; Dose-Response Relationship, Drug; Drug Intera | 1999 |
Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine.
Topics: Animals; Cell Line; Imidazoles; Ion Channels; Membrane Potentials; Mice; Neuroblastoma; Neurons; Ond | 1990 |
Physiological and pharmacological properties of 5-HT3 receptors--a patch clamp-study.
Topics: Action Potentials; Animals; Cocaine; Ganglia; Guinea Pigs; Imidazoles; Ion Channels; Ketamine; Metoc | 1991 |