ondansetron has been researched along with Muscle Contraction in 45 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell-shaped dose-response relationship." | 5.28 | The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. ( Moss, HE; Sanger, GJ, 1990) |
| " were hundreds of times more potent than 1 (ondansetron) and 2 (granisetron) in their inhibitory effects on cisplatin-induced emesis in ferrets and restraint stress-induced increases in fecal pellet output in rats." | 3.69 | Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives. ( Furuya, T; Kurihara, H; Miyata, K; Ohta, M; Suzuki, T; Tokunaga, T; Yanagisawa, I, 1996) |
| ") displaced the 5-HT dose-response curve to the right, with apparent DR2 values of 0." | 1.29 | Serotonin (5-HT)3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats. ( Honda, K; Ito, H; Kamato, T; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M; Yuki, H, 1994) |
| "6% acetic acid) in conscious rats with a bell-shaped dose-response curve." | 1.29 | Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model. ( Dahl, SG; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ, 1996) |
| ") had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell-shaped dose-response relationship." | 1.28 | The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. ( Moss, HE; Sanger, GJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 30 (66.67) | 18.2507 |
| 2000's | 11 (24.44) | 29.6817 |
| 2010's | 4 (8.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Youssefyeh, RD | 1 |
| Campbell, HF | 1 |
| Airey, JE | 1 |
| Klein, S | 1 |
| Schnapper, M | 1 |
| Powers, M | 1 |
| Woodward, R | 1 |
| Rodriguez, W | 1 |
| Golec, S | 1 |
| Studt, W | 1 |
| Robertson, DW | 1 |
| Lacefield, WB | 1 |
| Bloomquist, W | 1 |
| Pfeifer, W | 1 |
| Simon, RL | 1 |
| Cohen, ML | 2 |
| Bermudez, J | 1 |
| Fake, CS | 1 |
| Joiner, GF | 1 |
| Joiner, KA | 1 |
| King, FD | 1 |
| Miner, WD | 1 |
| Sanger, GJ | 2 |
| Monge, A | 1 |
| Palop, JA | 1 |
| Del Castillo, JC | 1 |
| Calderó, JM | 1 |
| Roca, J | 1 |
| Romero, G | 1 |
| Del Río, J | 1 |
| Lasheras, B | 1 |
| López-Rodríguez, ML | 2 |
| Benhamú, B | 2 |
| Morcillo, MJ | 1 |
| Tejada, ID | 1 |
| Orensanz, L | 1 |
| Alfaro, MJ | 1 |
| Martín, MI | 2 |
| Mahesh, R | 1 |
| Perumal, RV | 1 |
| Pandi, PV | 1 |
| Nam, Y | 1 |
| Lee, JM | 1 |
| Wang, Y | 1 |
| Ha, HS | 1 |
| Sohn, UD | 2 |
| Afzal, A | 1 |
| Khan, BT | 1 |
| Bakhtiar, S | 1 |
| Khin, PP | 1 |
| Zaw, TS | 1 |
| Taniguchi, H | 1 |
| Ariga, H | 1 |
| Zheng, J | 1 |
| Ludwig, K | 1 |
| Mantyh, C | 1 |
| Pappas, TN | 1 |
| Takahashi, T | 1 |
| Heredia, DJ | 1 |
| Dickson, EJ | 1 |
| Bayguinov, PO | 1 |
| Hennig, GW | 1 |
| Smith, TK | 1 |
| Johannsen, S | 1 |
| Roewer, N | 1 |
| Schuster, F | 1 |
| Pascual, D | 1 |
| Girón, R | 1 |
| Alsasua, A | 1 |
| Lograno, MD | 1 |
| Romano, MR | 1 |
| Liu, H | 1 |
| Irving, HR | 1 |
| Tan, YY | 1 |
| Meng, L | 1 |
| Chetty, N | 2 |
| Coupar, IM | 4 |
| Komada, T | 1 |
| Yano, S | 1 |
| Chess-Williams, R | 1 |
| Kerr, KP | 1 |
| Shiba, Y | 2 |
| Mizumoto, A | 4 |
| Inatomi, N | 1 |
| Haga, N | 1 |
| Yamamoto, O | 1 |
| Itoh, Z | 4 |
| Yamano, M | 1 |
| Kamato, T | 1 |
| Nishida, A | 1 |
| Ito, H | 1 |
| Yuki, H | 1 |
| Tsutsumi, R | 1 |
| Honda, K | 1 |
| Miyata, K | 4 |
| Desai, KM | 1 |
| Warner, TD | 1 |
| Vane, JR | 1 |
| Costall, B | 1 |
| Naylor, RJ | 2 |
| Tuladhar, BR | 2 |
| Davidson, HI | 1 |
| Andrews, PL | 1 |
| Kojima, S | 1 |
| Shimo, Y | 1 |
| Csillik-Perczel, V | 1 |
| Bakonyi, A | 1 |
| Yemane, T | 1 |
| Vitalis, B | 1 |
| Horvath, E | 1 |
| Solyom, S | 1 |
| Szekely, JI | 1 |
| Harsing, LG | 1 |
| Ohta, M | 3 |
| Suzuki, T | 3 |
| Furuya, T | 1 |
| Kurihara, H | 1 |
| Tokunaga, T | 2 |
| Yanagisawa, I | 2 |
| Nagashima, S | 1 |
| Mase, T | 1 |
| McLean, PG | 1 |
| Sevcík, J | 1 |
| Ruzicka, V | 1 |
| Slánsky, J | 1 |
| Masek, K | 1 |
| Langlois, A | 1 |
| Pascaud, X | 1 |
| Junien, JL | 1 |
| Dahl, SG | 1 |
| Rivière, PJ | 1 |
| Matsuhisa, A | 1 |
| González, AA | 1 |
| Puig, MM | 1 |
| Graf, S | 1 |
| Sarna, SK | 1 |
| Nakajima, M | 1 |
| Shiihara, Y | 1 |
| Sano, I | 1 |
| Sakai, T | 1 |
| Amemiya, N | 1 |
| Hatta, S | 1 |
| Ohshika, H | 1 |
| Hemedah, M | 1 |
| Mitchelson, FJ | 1 |
| Yokoyama, T | 1 |
| Takasaki, K | 1 |
| Kitazawa, T | 1 |
| Karasawa, A | 1 |
| Kusaka, H | 1 |
| Womack, MD | 1 |
| Bymaster, FP | 1 |
| Falcone, JF | 1 |
| Bauzon, D | 1 |
| Kennedy, JS | 1 |
| Schenck, K | 1 |
| DeLapp, NW | 1 |
| Tonini, M | 1 |
| Coccini, T | 1 |
| Onori, L | 1 |
| Candura, SM | 1 |
| Rizzi, CA | 1 |
| Manzo, L | 1 |
| Elswood, CJ | 1 |
| Bunce, KT | 1 |
| Humphrey, PP | 1 |
| Yoshida, N | 2 |
| Iwanaga, Y | 2 |
| Torii, K | 1 |
| Wakabayashi, K | 1 |
| Conti, A | 1 |
| Monopoli, A | 1 |
| Forlani, A | 1 |
| Ongini, E | 1 |
| Antona, C | 1 |
| Biglioli, P | 1 |
| Fox, A | 1 |
| Morton, IK | 1 |
| Moss, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Serotonin Signalling in IBD Patients[NCT01650311] | 60 participants (Anticipated) | Observational | 2012-07-31 | Recruiting | |||
| Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients[NCT02939287] | Phase 3 | 429 participants (Actual) | Interventional | 2017-09-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
45 other studies available for ondansetron and Muscle Contraction
| Article | Year |
|---|---|
Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides.
Topics: Amides; Animals; Antiemetics; Benzamides; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Co | 1992 |
Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Guinea Pig | 1992 |
5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.
Topics: Animals; Antiemetics; Carboxylic Acids; Ferrets; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; | 1990 |
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.
Topics: Animals; Brain; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Quinoxal | 1993 |
Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.
Topics: Animals; Benzimidazoles; Cell Membrane; Cerebral Cortex; Electric Stimulation; Guinea Pigs; Ileum; M | 1999 |
Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Microwaves; Muscle Contraction; Muscle, Smoo | 2004 |
The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function.
Topics: Animals; Benzamides; Carbachol; Cats; Cells, Cultured; Domperidone; Dose-Response Relationship, Drug | 2016 |
Ondansetron: A newer aspect of dose response relationship on ileal smooth muscles of rabbit.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Female; Ileum; In Vitro Techniques; Male; | 2016 |
Signal Transduction Underlying the Inhibitory Mechanism of Fluoxetine on Electrical Field Stimulation Response in Rat Ileal Smooth Muscle.
Topics: 4-Aminopyridine; Amides; Animals; Atropine; Azepines; Benzophenanthridines; Bicuculline; Calcimycin; | 2017 |
Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats.
Topics: Animals; Duodenum; Gastrointestinal Motility; Ghrelin; Growth Hormone-Releasing Hormone; Indoles; Ma | 2008 |
Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon.
Topics: Animals; Colon; Evoked Potentials; Feces; Female; Gastrointestinal Motility; Intestinal Mucosa; Male | 2009 |
Ondansetron-induced muscular contractures in malignant hyperthermia-susceptible individuals.
Topics: Adult; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Humans; Male; Malignant Hyp | 2012 |
New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.
Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Aza Compounds; Behavior, Animal; Benzimidazoles; | 2003 |
Pharmacological characterization of the 5-HT1A, 5-HT2 and 5-HT3 receptors in the bovine ciliary muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliar | 2003 |
Influences of gender and region on responses to 5-HT in the rat small intestine.
Topics: Acetylcholine; Animals; DNA, Complementary; Dose-Response Relationship, Drug; Estrous Cycle; Female; | 2004 |
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Emptying; Gastric Fundu | 2007 |
Demonstration of 5-HT(3) receptor function and expression in the mouse bladder.
Topics: Animals; Female; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth; Ondansetron; Protein | 2007 |
Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs.
Topics: Animals; Anti-Bacterial Agents; Atropine; Dipeptides; Dogs; Dopamine; Eating; Erythromycin; Hexameth | 1995 |
Serotonin (5-HT)3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats.
Topics: Animals; Benzimidazoles; Bradycardia; Colon; Disease Models, Animal; Dose-Response Relationship, Dru | 1994 |
5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig.
Topics: Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; In Vitro Techniques; Male; Metoclo | 1994 |
5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum.
Topics: 4-Aminobenzoic Acid; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro | 1993 |
Stimulation of gastrointestinal motility by cisplatin in the ferret: activation of an intrinsic cholinergic mechanism dissociated from emesis.
Topics: Animals; Atropine; Cisplatin; Female; Ferrets; Gastrointestinal Motility; Male; Muscle Contraction; | 1993 |
Investigation into the 5-hydroxytryptamine-induced atropine-resistant neurogenic contraction of guinea-pig proximal colon.
Topics: 5-Methoxytryptamine; Animals; Atropine; Colon; Dipeptides; Dose-Response Relationship, Drug; Guinea | 1996 |
GYKI-46 903, a non-competitive antagonist for 5-HT3 receptors.
Topics: 5-Methoxytryptamine; Animals; Binding, Competitive; Bradycardia; Bridged Bicyclo Compounds, Heterocy | 1996 |
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives.
Topics: Animals; Benzimidazoles; Cisplatin; Crystallography, X-Ray; Defecation; Ferrets; Guinea Pigs; In Vit | 1996 |
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. IV. Synthesis and pharmacological evaluation of the oxidation products of (-)-(R)-5-[(1-methyl-1H-indol-3-yl)carbonyl] -4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (YM060: ramosetron).
Topics: Animals; Benzimidazoles; Colon; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; M | 1996 |
Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; In Vitro Techniques; Jejunum; Male; | 1996 |
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?
Topics: Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Ketanse | 1996 |
Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Colon; Granisetron; Indoles; Male; Mus | 1996 |
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. Synthesis and structure-activity relationships of 9-methyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indol-4-one derivatives.
Topics: Animals; Colon; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Male; Muscle Contraction; Mus | 1997 |
Ondansetron facilitates neuromuscular transmission in the guinea-pig ileum.
Topics: 5-Methoxytryptamine; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles | 1997 |
5-HT-induced colonic contractions: enteric locus of action and receptor subtypes.
Topics: Animals; Atropine; Colon; Dogs; Granisetron; Hexamethonium; Infusions, Intra-Arterial; Methysergide; | 1997 |
Effect of 5-hydroxytryptamine on gastrointestinal motility in conscious guinea-pigs.
Topics: Animals; Atropine; Consciousness; Duodenum; Eating; Fasting; Female; Gastrointestinal Motility; Guin | 1997 |
Effects of ondansetron on electrically evoked contraction in rat stomach fundus: possible involvement of 5-HT2B receptors.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Electric Stimulation; Gastric Fundus; Hydrogen; Male; M | 1997 |
[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.
Topics: 5-Methoxytryptamine; Animals; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship | 1999 |
Change of the involvement of 5-HT3 receptor in the gastric motor stimulating actions of KW-5139 (Leu13-motilin acetate) in the recovered and post-operative periods in dogs.
Topics: Anesthesia Recovery Period; Animals; Atropine; Dinoprost; Dogs; Gastrointestinal Agents; Gastrointes | 2000 |
Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.
Topics: Animals; Atropine; Dioxanes; Dose-Response Relationship, Drug; Female; Granisetron; Ileum; In Vitro | 2000 |
Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relatio | 2001 |
The influence of neuronal 5-hydroxytryptamine receptor antagonists on non-cholinergic ganglionic transmission in the guinea-pig enteric excitatory reflex.
Topics: Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyc | 1992 |
Identification of putative 5-HT4 receptors in guinea-pig ascending colon.
Topics: Animals; Colon; Female; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Methysergide; Metoclo | 1991 |
Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Digestion; | 1991 |
Involvement of 5-hydroxytryptamine 3 receptors in regulation of interdigestive gastric contractions by motilin in the dog.
Topics: Acetylcholine; Animals; Digestion; Dogs; Gastrointestinal Motility; Granisetron; Imidazoles; Indazol | 1991 |
Role of 5-HT2 receptors in serotonin-induced contraction in the human mammary artery.
Topics: Female; Humans; Imidazoles; In Vitro Techniques; Ketanserin; Mammary Arteries; Muscle Contraction; M | 1990 |
An examination of the 5-HT3 receptor mediating contraction and evoked [3H]-acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contractio | 1990 |
The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension.
Topics: Animals; Blood Pressure; Duodenum; Granisetron; Imidazoles; Indazoles; Indoles; Male; Morphine; Musc | 1990 |