ondansetron has been researched along with Morning Sickness in 22 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Morning Sickness: Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy." | 9.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| "To study the association between ondansetron exposure during pregnancy and the risks of spontaneous abortion, stillbirth, and major congenital malformations." | 9.12 | Comparison of Pregnancy Outcomes of Patients Treated With Ondansetron vs Alternative Antiemetic Medications in a Multinational, Population-Based Cohort. ( Dahl, M; Dormuth, CR; Filion, KB; Fisher, A; Lu, X; Ma, Z; Moriello, C; Paterson, JM; Platt, RW; Raymond, CB; Reynier, P; Suissa, S; Winquist, B; Wu, F; Zhang, J, 2021) |
| "To use data from two large studies of birth defects to describe time trends in ondansetron use for the treatment of first-trimester nausea and vomiting of pregnancy and to investigate associations, either previously reported or undescribed, between first-trimester ondansetron use and major birth defects." | 7.88 | Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. ( Anderka, M; Mitchell, AA; Parker, SE; Van Bennekom, C, 2018) |
| "Our study did not detect any adverse outcomes from the use of ondansetron in pregnancy but could not conclude that ondansetron is safe to use in pregnancy." | 7.79 | Off-label use of ondansetron in pregnancy in Western Australia. ( Bower, C; Colvin, L; Gill, AW; Slack-Smith, L; Stanley, FJ, 2013) |
| "While I usually prescribe doxylamine-pyridoxine for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital." | 7.78 | Motherisk update. Is ondansetron safe for use during pregnancy? ( Koren, G, 2012) |
| "Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy." | 5.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| "To study the association between ondansetron exposure during pregnancy and the risks of spontaneous abortion, stillbirth, and major congenital malformations." | 5.12 | Comparison of Pregnancy Outcomes of Patients Treated With Ondansetron vs Alternative Antiemetic Medications in a Multinational, Population-Based Cohort. ( Dahl, M; Dormuth, CR; Filion, KB; Fisher, A; Lu, X; Ma, Z; Moriello, C; Paterson, JM; Platt, RW; Raymond, CB; Reynier, P; Suissa, S; Winquist, B; Wu, F; Zhang, J, 2021) |
| "To use data from two large studies of birth defects to describe time trends in ondansetron use for the treatment of first-trimester nausea and vomiting of pregnancy and to investigate associations, either previously reported or undescribed, between first-trimester ondansetron use and major birth defects." | 3.88 | Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. ( Anderka, M; Mitchell, AA; Parker, SE; Van Bennekom, C, 2018) |
| "To examine ondansetron use in pregnancy in the context of other antiemetic use among a large insured United States population of women delivering live births." | 3.85 | Antiemetic use among pregnant women in the United States: the escalating use of ondansetron. ( Andrade, SE; Bird, ST; Greene, P; Haffenreffer, K; Reichman, ME; Sahin, L; Tassinari, MS; Taylor, LG; Toh, S, 2017) |
| "The use of ondansetron in the ED for nausea and vomiting of pregnancy was associated with similar mean time from administration to disposition as other antiemetics." | 3.81 | Comparison of antiemetics for nausea and vomiting of pregnancy in an emergency department setting. ( Gray, R; Lopes, V; Matteson, KA; Mayhall, EA, 2015) |
| "Our study did not detect any adverse outcomes from the use of ondansetron in pregnancy but could not conclude that ondansetron is safe to use in pregnancy." | 3.79 | Off-label use of ondansetron in pregnancy in Western Australia. ( Bower, C; Colvin, L; Gill, AW; Slack-Smith, L; Stanley, FJ, 2013) |
| " For morning sickness, 89% of those replying give dietary advice frequently or always, and 70% prescribe metoclopramide frequently or always, whereas 59% advise pyridoxine and 10% prescribe doxylamine." | 3.79 | A survey of prescribing for the management of nausea and vomiting in pregnancy in Australasia. ( Raymond, SH, 2013) |
| "While I usually prescribe doxylamine-pyridoxine for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital." | 3.78 | Motherisk update. Is ondansetron safe for use during pregnancy? ( Koren, G, 2012) |
| "Ondansetron is a 5-HT₃ receptor antagonist that has been approved for the prevention of nausea and vomiting associated with cancer chemotherapy, radiotherapy, and surgery." | 2.66 | Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron. ( Andrade, C, 2020) |
| "Of note, co-existing gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and psychosocial factors may have a negative impact on the management of NVP." | 2.50 | The outpatient management and special considerations of nausea and vomiting in pregnancy. ( Clark, SM; Dutta, E; Hankins, GD, 2014) |
| "Nausea during pregnancy affects 80% of pregnant women and can severely affect women's functioning and quality of life." | 1.48 | Getting through the day: a pilot qualitative study of U.S. women's experiences making decisions about anti-nausea medication during pregnancy. ( Dublin, S; Figueroa Gray, M; Hsu, C; Kiel, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 18 (81.82) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, KL | 1 |
| Wilson, M | 1 |
| Vincent, EC | 1 |
| Safranek, S | 1 |
| Andrade, C | 1 |
| MacDuffie, KE | 1 |
| Kleinhans, NM | 1 |
| Stout, K | 1 |
| Wilfond, BS | 1 |
| Dormuth, CR | 1 |
| Winquist, B | 1 |
| Fisher, A | 1 |
| Wu, F | 1 |
| Reynier, P | 1 |
| Suissa, S | 1 |
| Dahl, M | 1 |
| Ma, Z | 1 |
| Lu, X | 1 |
| Zhang, J | 1 |
| Raymond, CB | 1 |
| Filion, KB | 1 |
| Platt, RW | 1 |
| Moriello, C | 1 |
| Paterson, JM | 1 |
| Parker, SE | 1 |
| Van Bennekom, C | 1 |
| Anderka, M | 1 |
| Mitchell, AA | 1 |
| Figueroa Gray, M | 1 |
| Hsu, C | 1 |
| Kiel, L | 1 |
| Dublin, S | 1 |
| Kiernan, E | 1 |
| Jones, KL | 1 |
| Lehmann, AS | 1 |
| Renbarger, JL | 1 |
| McCormick, CL | 1 |
| Topletz, AR | 1 |
| Rouse, C | 1 |
| Haas, DM | 1 |
| Colvin, L | 1 |
| Gill, AW | 1 |
| Slack-Smith, L | 1 |
| Stanley, FJ | 1 |
| Bower, C | 1 |
| Furyk, JS | 1 |
| Meek, R | 1 |
| McKenzie, S | 1 |
| Koren, G | 4 |
| Oliveira, LG | 1 |
| Capp, SM | 1 |
| You, WB | 1 |
| Riffenburgh, RH | 1 |
| Carstairs, SD | 1 |
| Clark, SM | 1 |
| Dutta, E | 1 |
| Hankins, GD | 1 |
| Maltepe, C | 2 |
| Madjunkova, S | 1 |
| Cunningham, K | 1 |
| Oliveira, L | 1 |
| Capp, S | 1 |
| Mayhall, EA | 1 |
| Gray, R | 1 |
| Lopes, V | 1 |
| Matteson, KA | 1 |
| Taylor, LG | 1 |
| Bird, ST | 1 |
| Sahin, L | 1 |
| Tassinari, MS | 1 |
| Greene, P | 1 |
| Reichman, ME | 1 |
| Andrade, SE | 1 |
| Haffenreffer, K | 1 |
| Toh, S | 1 |
| Raymond, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069] | 36 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for ondansetron and Morning Sickness
| Article | Year |
|---|---|
Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron.
Topics: Abnormalities, Drug-Induced; Administration, Intravenous; Administration, Oral; Antiemetics; Female; | 2020 |
Comparison of Pregnancy Outcomes of Patients Treated With Ondansetron vs Alternative Antiemetic Medications in a Multinational, Population-Based Cohort.
Topics: Abortion, Spontaneous; Adult; Antiemetics; Canada; Cohort Studies; Congenital Abnormalities; Databas | 2021 |
Medications that Cause Fetal Anomalies and Possible Prevention Strategies.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Analg | 2019 |
The outpatient management and special considerations of nausea and vomiting in pregnancy.
Topics: Ambulatory Care; Antiemetics; Diet Therapy; Doxylamine; Female; Fluid Therapy; Gastroesophageal Refl | 2014 |
1 trial available for ondansetron and Morning Sickness
| Article | Year |
|---|---|
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St | 2014 |
17 other studies available for ondansetron and Morning Sickness
| Article | Year |
|---|---|
How safe and effective is ondansetron for nausea and vomiting in pregnancy?
Topics: Antiemetics; Female; Humans; Morning Sickness; Ondansetron; Pregnancy | 2019 |
Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Ethics, Research; Female; Hu | 2020 |
Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Case-Control Studies; Drug Administration Schedule; | 2018 |
Getting through the day: a pilot qualitative study of U.S. women's experiences making decisions about anti-nausea medication during pregnancy.
Topics: Adolescent; Adult; Antiemetics; Decision Making; Female; Focus Groups; Humans; Morning Sickness; Ond | 2018 |
Ondansetron looks safe in pregnancy, so far.
Topics: Antiemetics; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pregnancy Outcome; Pregnancy | 2013 |
Pharmacogenetic predictors of nausea and vomiting of pregnancy severity and response to antiemetic therapy: a pilot study.
Topics: Adult; Antiemetics; Female; Humans; Metoclopramide; Morning Sickness; Ondansetron; Pilot Projects; P | 2013 |
Off-label use of ondansetron in pregnancy in Western Australia.
Topics: Adult; Antiemetics; Congenital Abnormalities; Female; Humans; Hyperemesis Gravidarum; Infant, Newbor | 2013 |
Drug treatment of adults with nausea and vomiting in primary care.
Topics: Adult; Antiemetics; Domperidone; Droperidol; Female; Histamine Antagonists; Humans; Male; Metoclopra | 2014 |
Treating morning sickness in the United States--changes in prescribing are needed.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Heart Defects, Conge | 2014 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Odansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
In reply.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Comparison of antiemetics for nausea and vomiting of pregnancy in an emergency department setting.
Topics: Adult; Antiemetics; Cohort Studies; Emergency Service, Hospital; Female; Humans; Hypotension, Orthos | 2015 |
Antiemetic use among pregnant women in the United States: the escalating use of ondansetron.
Topics: Adult; Algorithms; Antiemetics; Female; Humans; Morning Sickness; Ondansetron; Pilot Projects; Pract | 2017 |
Motherisk update. Is ondansetron safe for use during pregnancy?
Topics: Antiemetics; Canada; Cleft Palate; Female; Fetus; Humans; Long QT Syndrome; Morning Sickness; Nausea | 2012 |
A survey of prescribing for the management of nausea and vomiting in pregnancy in Australasia.
Topics: Antiemetics; Australia; Dopamine Antagonists; Female; Histamine Antagonists; Humans; Hyperemesis Gra | 2013 |
Preventing recurrence of severe morning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morning Sickness; Ondansetr | 2006 |