ondansetron has been researched along with Long QT Syndrome in 30 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have sought to determine the effect of a standardized dose of intravenous ondansetron on the QTc duration of children under 14years of age treated for gastroenteritis-associated vomiting in a pediatric ED." | 7.88 | Effect of intravenous ondansetron on QTc interval in children with gastroenteritis. ( Alansari, K; Hoffman, RJ, 2018) |
| "While I usually prescribe doxylamine-pyridoxine for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital." | 7.78 | Motherisk update. Is ondansetron safe for use during pregnancy? ( Koren, G, 2012) |
| " Physicians and pharmacists should be cautious for drug-drug interactions when pipamperon is prescribed, especially in combination with other QT-prolongating agents." | 5.48 | Drug-drug interaction related to the use of pipamperon and ondansetron in a child treated for leukemia. ( Bauters, T; Bordon, V; Buts, S; Laureys, G, 2018) |
| "To describe a case of ventricular tachycardia after co-administration of ondansetron and dimenhydrinate to a child with occult congenital QT prolongation." | 5.36 | Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome. ( Froese, A; McKechnie, K, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 5.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| " Ondansetron, which is widely used in treatment of nausea and vomiting symptoms in head injuries, was issued a safety warning from the U." | 4.31 | Ondansetron Safety Regarding Prolong QTc for Children with Head Trauma. ( Assaad, R; Pratt, RE; Qiao, H; Territo, HM; Wrotniak, BH, 2023) |
| "We have sought to determine the effect of a standardized dose of intravenous ondansetron on the QTc duration of children under 14years of age treated for gastroenteritis-associated vomiting in a pediatric ED." | 3.88 | Effect of intravenous ondansetron on QTc interval in children with gastroenteritis. ( Alansari, K; Hoffman, RJ, 2018) |
| "This was an observational study looking at patients aged 6 months to 18 years receiving intravenous ondansetron for nausea, vomiting, or the inability to take fluids in the emergency department." | 3.88 | Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms. ( Clark, JM; Jacobs, T; Krammes, SK; Lutes, RE, 2018) |
| "While I usually prescribe doxylamine-pyridoxine for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital." | 3.78 | Motherisk update. Is ondansetron safe for use during pregnancy? ( Koren, G, 2012) |
| "Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization." | 2.80 | Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study. ( Owczuk, R; Tracz, K, 2015) |
| "The purpose of this article is to outline the risk of cardiac adverse events (AEs) from 5-HT3-RAs, with focus on the three most commonly used, ondansetron, granisetron and palonosetron." | 2.50 | 5-Hydroxytryptamine3 receptor antagonists and cardiac side effects. ( Brygger, L; Herrstedt, J, 2014) |
| "Ondansetron is a commonly used antiemetic in the emergency department despite a 2011 FDA warning regarding dose-related QTc prolongation and torsades des pointes (TdP)." | 1.91 | QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron. ( Cole, JB; Fuchs, RT; Fushianes, GD; Lee, SC; Orozco, BS, 2023) |
| " Physicians and pharmacists should be cautious for drug-drug interactions when pipamperon is prescribed, especially in combination with other QT-prolongating agents." | 1.48 | Drug-drug interaction related to the use of pipamperon and ondansetron in a child treated for leukemia. ( Bauters, T; Bordon, V; Buts, S; Laureys, G, 2018) |
| "Ondansetron is known to cause QT interval prolongation, but this effect and clinical significance has not been prospectively studied in adult emergency department (ED) patients." | 1.43 | Intravenous Ondansetron and the QT Interval in Adult Emergency Department Patients: An Observational Study. ( Cartwright, L; Grossart, EA; Kang, CS; Moffett, PM; O'Keefe, D, 2016) |
| "To determine the most common drug-drug interaction (DDI) pairs contributing to QTc prolongation in cardiac intensive care units (ICUs)." | 1.39 | Drug-drug interactions contributing to QT prolongation in cardiac intensive care units. ( Armahizer, MJ; Kane-Gill, SL; Seybert, AL; Smithburger, PL, 2013) |
| "Ondansetron is a 5-HT3 receptor antagonist commonly prescribed to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery but may increase the risk of developing prolongation of the QT interval of the electrocardiogram, which can lead to an abnormal and potentially fatal heart rhythm and recently raised FDA concerns and warnings." | 1.38 | Nifedipine blocks ondansetron electrophysiological effects in rabbit purkinje fibers and decreases early after depolarization incidence. ( Gerard, JL; Hanouz, JL; Lemoine, S; Plaud, B; Puddu, PE; Rouet, R; Salle, L; Worou, ME, 2012) |
| "To describe a case of ventricular tachycardia after co-administration of ondansetron and dimenhydrinate to a child with occult congenital QT prolongation." | 1.36 | Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome. ( Froese, A; McKechnie, K, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 1.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 19 (63.33) | 24.3611 |
| 2020's | 9 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, H | 1 |
| Jeon, W | 1 |
| Ko, Y | 1 |
| Jeong, S | 1 |
| Lee, J | 1 |
| Assaad, R | 1 |
| Pratt, RE | 1 |
| Wrotniak, BH | 1 |
| Qiao, H | 1 |
| Territo, HM | 1 |
| Orozco, BS | 1 |
| Lee, SC | 1 |
| Fuchs, RT | 1 |
| Fushianes, GD | 1 |
| Cole, JB | 1 |
| Safaeian, R | 1 |
| Hassani, V | 1 |
| Asghari, A | 1 |
| Mohseni, M | 1 |
| Ashraf, H | 1 |
| Koleini, ZS | 1 |
| Al-Khalil, M | 1 |
| Sack, A | 1 |
| Elson, R | 1 |
| Pleat, J | 1 |
| Miller, J | 1 |
| House, S | 1 |
| Lovato, L | 1 |
| Meltzer, A | 1 |
| Hahn, B | 1 |
| Avarello, J | 1 |
| Plasse, T | 1 |
| Kalfus, I | 1 |
| Fathi, R | 1 |
| Silverman, R | 1 |
| Kamath, A | 1 |
| Rai, KM | 1 |
| Shreyas, R | 1 |
| Saxena, PUP | 1 |
| Banerjee, S | 1 |
| Sutherland, H | 1 |
| Miller, M | 1 |
| Tomanec, A | 1 |
| Xu, KT | 1 |
| Barton, T | 1 |
| Richman, P | 1 |
| Bauters, T | 1 |
| Buts, S | 1 |
| Bordon, V | 1 |
| Laureys, G | 1 |
| Hoffman, RJ | 1 |
| Alansari, K | 1 |
| Ko, JS | 1 |
| Guo, S | 1 |
| Hassel, J | 1 |
| Celestino-Soper, P | 1 |
| Lynnes, TC | 1 |
| Tisdale, JE | 1 |
| Zheng, JJ | 1 |
| Taylor, SE | 1 |
| Foroud, T | 1 |
| Murray, MD | 1 |
| Kovacs, RJ | 1 |
| Li, X | 1 |
| Lin, SF | 1 |
| Chen, Z | 1 |
| Vatta, M | 1 |
| Chen, PS | 1 |
| Rubart, M | 1 |
| Darpo, B | 1 |
| Benson, C | 1 |
| Brown, R | 1 |
| Dota, C | 1 |
| Ferber, G | 1 |
| Ferry, J | 1 |
| Jarugula, V | 1 |
| Keirns, J | 1 |
| Ortemann-Renon, C | 1 |
| Pham, T | 1 |
| Riley, S | 1 |
| Sarapa, N | 1 |
| Ticktin, M | 1 |
| Zareba, W | 1 |
| Couderc, JP | 1 |
| Patel, J | 1 |
| Lee, JH | 2 |
| Park, YH | 1 |
| Kim, JT | 1 |
| Kim, CS | 1 |
| Kim, HS | 1 |
| Obal, D | 1 |
| Yang, D | 1 |
| Sessler, DI | 1 |
| Marzuillo, P | 1 |
| Benettoni, A | 1 |
| Germani, C | 1 |
| Ferrara, G | 1 |
| D'Agata, B | 1 |
| Barbi, E | 1 |
| Brygger, L | 1 |
| Herrstedt, J | 1 |
| Tracz, K | 1 |
| Owczuk, R | 1 |
| Kim, SH | 1 |
| Lee, SM | 1 |
| Kim, YK | 1 |
| Park, SY | 1 |
| Cho, SH | 1 |
| Chai, WS | 1 |
| Jin, HC | 1 |
| Moffett, PM | 1 |
| Cartwright, L | 1 |
| Grossart, EA | 1 |
| O'Keefe, D | 1 |
| Kang, CS | 1 |
| Krammes, SK | 1 |
| Jacobs, T | 1 |
| Clark, JM | 1 |
| Lutes, RE | 1 |
| Trivedi, S | 1 |
| Schiltz, B | 1 |
| Kanipakam, R | 1 |
| Bos, JM | 1 |
| Ackerman, MJ | 1 |
| Ouellette, Y | 1 |
| Charbit, B | 2 |
| Alvarez, JC | 1 |
| Dasque, E | 1 |
| Abe, E | 1 |
| Démolis, JL | 1 |
| Funck-Brentano, C | 2 |
| McKechnie, K | 1 |
| Froese, A | 1 |
| Mehta, D | 1 |
| Sanatani, S | 1 |
| Whyte, SD | 1 |
| Rouet, R | 1 |
| Worou, ME | 1 |
| Puddu, PE | 1 |
| Lemoine, S | 1 |
| Plaud, B | 1 |
| Salle, L | 1 |
| Gerard, JL | 1 |
| Hanouz, JL | 1 |
| Koren, G | 1 |
| Armahizer, MJ | 1 |
| Seybert, AL | 1 |
| Smithburger, PL | 1 |
| Kane-Gill, SL | 1 |
| Albaladejo, P | 1 |
| Legrand, M | 1 |
| Samain, E | 1 |
| Marty, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical ECG Study to Evaluate Electrophysiological Effects of Potential QT Prolonging Drugs With Novel ECG Biomarkers With Exposure-Response Analysis[NCT05716854] | Phase 1 | 44 participants (Actual) | Interventional | 2023-03-21 | Completed | ||
| Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position[NCT03232125] | 54 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ondansetron and Long QT Syndrome
| Article | Year |
|---|---|
Droperidol- and ondansetron-induced life-threatening arrhythmias.
Topics: Aged; Antiemetics; Arrhythmias, Cardiac; Droperidol; Fatal Outcome; Female; Humans; Long QT Syndrome | 2013 |
Acquired long QT syndrome: a focus for the general pediatrician.
Topics: Adolescent; Death, Sudden, Cardiac; Electrocardiography; Female; General Practitioners; Humans; Long | 2014 |
5-Hydroxytryptamine3 receptor antagonists and cardiac side effects.
Topics: Aged; Antiemetics; Antineoplastic Agents; Cardiovascular Diseases; Granisetron; Humans; Isoquinoline | 2014 |
7 trials available for ondansetron and Long QT Syndrome
| Article | Year |
|---|---|
The effects of ondansetron versus dexamethasone on electrocardiographic markers of ventricular repolarization in children undergoing cochlear implant.
Topics: Antiemetics; Child; Cochlear Implantation; Cochlear Implants; Deafness; Dexamethasone; Double-Blind | 2020 |
Absence of QT prolongation after administration of a 24-mg bimodal-release ondansetron pill (RHB-102).
Topics: Administration, Oral; Adolescent; Adult; Antiemetics; Delayed-Action Preparations; Double-Blind Meth | 2021 |
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
Topics: Arrhythmias, Cardiac; Biomarkers; Cetirizine; Drug-Related Side Effects and Adverse Reactions; Elect | 2020 |
Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Topics: Adolescent; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; E | 2015 |
Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia.
Topics: Adult; Aged; Anesthesia, General; Antiemetics; Benzimidazoles; Cholecystectomy, Laparoscopic; Dose-R | 2014 |
Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study.
Topics: Adult; Antiemetics; Area Under Curve; Cross-Over Studies; Double-Blind Method; Droperidol; Drug Inte | 2008 |
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Topics: Ambulatory Surgical Procedures; Antiemetics; Child, Preschool; Droperidol; Electrocardiography; Fema | 2010 |
20 other studies available for ondansetron and Long QT Syndrome
| Article | Year |
|---|---|
The effect of oral ondansetron on QT interval in children with acute gastroenteritis; a retrospective observational study.
Topics: Antiemetics; Child; Child, Preschool; Electrocardiography; Gastroenteritis; Humans; Infant; Long QT | 2021 |
Ondansetron Safety Regarding Prolong QTc for Children with Head Trauma.
Topics: Adult; Antiemetics; Child; Craniocerebral Trauma; Electrocardiography; Humans; Long QT Syndrome; Nau | 2023 |
QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron.
Topics: Adult; Antiemetics; DNA-Binding Proteins; Electrocardiography; Female; Heart Arrest; Humans; Long QT | 2023 |
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int | 2020 |
Effect of domperidone, ondansetron, olanzapine-containing antiemetic regimen on QT
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Domperidone; Drug Co | 2021 |
QTc interval changes following low-dose ondansetron administration in the emergency department.
Topics: Antiemetics; Electrocardiography; Emergency Service, Hospital; Humans; Long QT Syndrome; Ondansetron | 2022 |
Drug-drug interaction related to the use of pipamperon and ondansetron in a child treated for leukemia.
Topics: Butyrophenones; Child; Drug Interactions; Electrocardiography; Humans; Leukemia; Long QT Syndrome; M | 2018 |
Effect of intravenous ondansetron on QTc interval in children with gastroenteritis.
Topics: Administration, Intravenous; Adolescent; Antiemetics; Child; Child, Preschool; Electrocardiography; | 2018 |
Ondansetron blocks wild-type and p.F503L variant small-conductance Ca
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Cells, Cultured; Female; HEK293 Cells; Humans; Long QT Syn | 2018 |
The effect of sevoflurane and ondansetron on QT interval and transmural dispersion of repolarization in children.
Topics: Adolescent; Anesthetics, Inhalation; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Co | 2014 |
Perioperative doses of ondansetron or dolasetron do not lengthen the QT interval.
Topics: Aged; Aged, 80 and over; Female; Heart Rate; Humans; Indoles; Long QT Syndrome; Male; Middle Aged; O | 2014 |
Intravenous Ondansetron and the QT Interval in Adult Emergency Department Patients: An Observational Study.
Topics: Adult; Aged; Antiemetics; Cohort Studies; Electrocardiography; Emergency Service, Hospital; Female; | 2016 |
Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms.
Topics: Adolescent; Antiemetics; Child; Child, Preschool; Electrocardiography; Female; Humans; Infant; Long | 2018 |
Effect of Ondansetron on QT Interval in Patients Cared for in the PICU.
Topics: Adolescent; Antiemetics; Child; Child, Preschool; Critical Care; Electrocardiography; Female; Humans | 2016 |
Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome.
Topics: Antiemetics; Child; Dimenhydrinate; Drug Therapy, Combination; Electrocardiography; Female; Humans; | 2010 |
Nifedipine blocks ondansetron electrophysiological effects in rabbit purkinje fibers and decreases early after depolarization incidence.
Topics: Animals; Antiemetics; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship | 2012 |
Motherisk update. Is ondansetron safe for use during pregnancy?
Topics: Antiemetics; Canada; Cleft Palate; Female; Fetus; Humans; Long QT Syndrome; Morning Sickness; Nausea | 2012 |
In brief: intravenous ondanstron (Zofran) 32 mg withdrawn.
Topics: Antiemetics; Antineoplastic Agents; Humans; Long QT Syndrome; Nausea; Ondansetron; Product Recalls a | 2012 |
Drug-drug interactions contributing to QT prolongation in cardiac intensive care units.
Topics: Amiodarone; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Infective Agents; Antipsychotic Agents | 2013 |
Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron.
Topics: Adult; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Ondanse | 2005 |