ondansetron has been researched along with Innate Inflammatory Response in 10 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Daily administration of ramosetron and ondansetron (5-HT3 antagonists) dose-dependently attenuated the severity of DSS-induced colitis and up-regulation of inflammatory mediator expression." | 7.83 | 5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis. ( Amagase, K; Horie, S; Kato, S; Matsumoto, K; Utsumi, D, 2016) |
| "There is a clear unmet need for new treatments in irritable bowel syndrome with diarrhea (IBS-D)." | 5.56 | Positive Effect of Bimodal Release Ondansetron in Irritable Bowel Syndrome With Diarrhea: Relevance of Low-Grade Inflammation? ( Melchior, C; Simrén, M, 2020) |
| "Daily administration of ramosetron and ondansetron (5-HT3 antagonists) dose-dependently attenuated the severity of DSS-induced colitis and up-regulation of inflammatory mediator expression." | 3.83 | 5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis. ( Amagase, K; Horie, S; Kato, S; Matsumoto, K; Utsumi, D, 2016) |
| "The role of peripheral 5-HT3 receptors in the nociceptive behavioral response and the effect of the 5-HT3 antagonist ondansetron on indices of acute and tonic pain were investigated in the formalin test in 25- and 90-day-old Wistar male rats." | 3.74 | [Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress]. ( Butkevich, IP; Makukhina, GV; Mikhaĭlenko, VA, 2007) |
| " To determine if this pathway plays a role in the pathophysiology of inflammation, we investigated the effects of spinally administered ondansetron (a selective 5HT3 receptor antagonist) on deep dorsal horn neuronal responses in carrageenan inflamed and naïve animals using in vivo electrophysiology." | 3.72 | Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. ( Dickenson, AH; Rahman, W; Rygh, LJ; Suzuki, R, 2004) |
| "Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds." | 2.66 | Post-Burn Pruritus. ( Chung, BY; Jung, MJ; Kang, SY; Kim, HB; Kim, HO; Kwak, IS; Park, CW, 2020) |
| "There is a clear unmet need for new treatments in irritable bowel syndrome with diarrhea (IBS-D)." | 1.56 | Positive Effect of Bimodal Release Ondansetron in Irritable Bowel Syndrome With Diarrhea: Relevance of Low-Grade Inflammation? ( Melchior, C; Simrén, M, 2020) |
| "Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules." | 1.48 | LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. ( Alencar Filho, EB; Almeida, JRGDS; Barreiro, EJL; Diniz, TC; Lavor, ÉM; Lima, LM; Lima-Saraiva, SRG; Mendes, RL; Oliveira Júnior, RG; Silva, JC; Silva, MGE; Soares, JMD, 2018) |
| "Snakebites are common in many regions of the United States." | 1.46 | White-Lipped Tree Viper (Cryptelytrops albolabris) Envenomation in an American Viper Keeper. ( Galdamez, LA; Greene, S; Tomasheski, R, 2017) |
| "The SP-induced hyperalgesia was both GABA(A) and NMDA receptor-dependent after pre- and post-treatment with selective antagonists at the spinal level." | 1.36 | Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. ( Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, BY | 1 |
| Kim, HB | 1 |
| Jung, MJ | 1 |
| Kang, SY | 1 |
| Kwak, IS | 1 |
| Park, CW | 1 |
| Kim, HO | 1 |
| Melchior, C | 1 |
| Simrén, M | 1 |
| Greene, S | 1 |
| Galdamez, LA | 1 |
| Tomasheski, R | 1 |
| Silva, JC | 1 |
| Oliveira Júnior, RG | 1 |
| Silva, MGE | 1 |
| Lavor, ÉM | 1 |
| Soares, JMD | 1 |
| Lima-Saraiva, SRG | 1 |
| Diniz, TC | 1 |
| Mendes, RL | 1 |
| Alencar Filho, EB | 1 |
| Barreiro, EJL | 1 |
| Lima, LM | 1 |
| Almeida, JRGDS | 1 |
| Utsumi, D | 1 |
| Matsumoto, K | 1 |
| Amagase, K | 1 |
| Horie, S | 1 |
| Kato, S | 1 |
| Asante, CO | 1 |
| Dickenson, AH | 2 |
| Lagraize, SC | 1 |
| Guo, W | 1 |
| Yang, K | 1 |
| Wei, F | 1 |
| Ren, K | 1 |
| Dubner, R | 1 |
| Rahman, W | 1 |
| Suzuki, R | 1 |
| Rygh, LJ | 1 |
| Butkevich, IP | 1 |
| Mikhaĭlenko, VA | 1 |
| Makukhina, GV | 1 |
| Sufka, KJ | 1 |
| Schomburg, FM | 1 |
| Giordano, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns[NCT06104540] | 24 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ondansetron and Innate Inflammatory Response
| Article | Year |
|---|---|
Post-Burn Pruritus.
Topics: Animals; Antipsychotic Agents; Burns; Gabapentin; Histamine Antagonists; Humans; Inflammation; Kerat | 2020 |
9 other studies available for ondansetron and Innate Inflammatory Response
| Article | Year |
|---|---|
Positive Effect of Bimodal Release Ondansetron in Irritable Bowel Syndrome With Diarrhea: Relevance of Low-Grade Inflammation?
Topics: Diarrhea; Double-Blind Method; Humans; Inflammation; Irritable Bowel Syndrome; Ondansetron | 2020 |
White-Lipped Tree Viper (Cryptelytrops albolabris) Envenomation in an American Viper Keeper.
Topics: Adult; Analgesics, Opioid; Animals; Antiemetics; Antivenins; Dyspnea; Emergency Service, Hospital; F | 2017 |
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrage | 2018 |
5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.
Topics: Animals; Benzimidazoles; Colitis; Colon; Dextran Sulfate; Dose-Response Relationship, Drug; Inflamma | 2016 |
Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal rapamycin-sensitive pathways in the rat.
Topics: Action Potentials; Afferent Pathways; Animals; Carrageenan; Dose-Response Relationship, Drug; Drug I | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilp | 2010 |
Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation.
Topics: Animals; Brain Stem; Carrageenan; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stim | 2004 |
[Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress].
Topics: Aging; Analgesics; Animals; Female; Inflammation; Male; Ondansetron; Pain; Phenylalanine; Pregnancy; | 2007 |
Receptor mediation of 5-HT-induced inflammation and nociception in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Ketanserin; M | 1992 |