Page last updated: 2024-11-01

ondansetron and Dystonia

ondansetron has been researched along with Dystonia in 10 studies

Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)

Research Excerpts

ExcerptRelevanceReference
"To document ondansetron-induced dystonia, hypoglycemia, and seizures in a child."7.77Ondansetron-induced dystonia, hypoglycemia, and seizures in a child. ( Manchanda, S; Mittal, S; Patel, A; Puliyel, JM, 2011)
"Acute, severe dystonia is a frightening and potentially life-threatening surgical complication."5.56Acute, severe dystonia after strabismus surgery in a patient on propofol, ondansetron, and bupropion. ( Dagi, LR; Elhusseiny, AM; Grush, A, 2020)
"Ondansetron, a new 5-HT3 receptor antagonist, has been compared with high-dose metoclopramide in the control of acute emesis (24 h) induced by cisplatin (greater than or equal to 100 mg/m2)."5.07Progress in the control of acute and delayed emesis induced by cisplatin. ( Gandara, DR, 1991)
"To document ondansetron-induced dystonia, hypoglycemia, and seizures in a child."3.77Ondansetron-induced dystonia, hypoglycemia, and seizures in a child. ( Manchanda, S; Mittal, S; Patel, A; Puliyel, JM, 2011)
"We treated a patient who developed transient multifocal encephalopathy with extrapyramidal symptoms (oromandibular dystonia, oculogyric crisis, and limb dystonia) in temporal proximity to ondansetron administration on emergence from general anesthesia."3.72Ondansetron-induced multifocal encephalopathy. ( Goodman, BP; Ritter, MJ; Sprung, J; Wijdicks, EF, 2003)
"Acute, severe dystonia is a frightening and potentially life-threatening surgical complication."1.56Acute, severe dystonia after strabismus surgery in a patient on propofol, ondansetron, and bupropion. ( Dagi, LR; Elhusseiny, AM; Grush, A, 2020)
"Ondansetron was the only medication administered that had previously been associated with dystonic reactions."1.42Dystonic reaction associated with ondansetron administration in a patient with normal pressure hydrocephalus. ( Diaz-Parlet, J; Subramani, S, 2015)
"The onset of dystonia coincided temporally with the removal of a transdermal scopolamine patch used as adjunctive antiemetic therapy."1.33Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch. ( Roberge, RJ, 2006)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's5 (50.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Elhusseiny, AM1
Grush, A1
Dagi, LR1
Diaz-Parlet, J1
Subramani, S1
Patel, A2
Mittal, S1
Manchanda, S1
Puliyel, JM1
Size, MH1
Rubin, JS1
Ritter, MJ1
Goodman, BP1
Sprung, J2
Wijdicks, EF1
Sinclair, RC1
Bedforth, NM1
Roberge, RJ1
Ramakrishna, H1
Trentman, TL1
Hall, BA1
Ananthanarayan, C1
Blight, K1
Gandara, DR1

Trials

1 trial available for ondansetron and Dystonia

ArticleYear
Progress in the control of acute and delayed emesis induced by cisplatin.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27 Suppl 1

    Topics: Akathisia, Drug-Induced; Cisplatin; Dystonia; Humans; Imidazoles; Metoclopramide; Ondansetron; Serot

1991

Other Studies

9 other studies available for ondansetron and Dystonia

ArticleYear
Acute, severe dystonia after strabismus surgery in a patient on propofol, ondansetron, and bupropion.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2020, Volume: 24, Issue:5

    Topics: Adult; Antiemetics; Bupropion; Double-Blind Method; Dystonia; Female; Humans; Ondansetron; Propofol;

2020
Dystonic reaction associated with ondansetron administration in a patient with normal pressure hydrocephalus.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:5

    Topics: Aged; Anesthesia, General; Dystonia; Female; Humans; Hydrocephalus, Normal Pressure; Intracranial Pr

2015
Ondansetron-induced dystonia, hypoglycemia, and seizures in a child.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:1

    Topics: Antiemetics; Child, Preschool; Dystonia; Humans; Hypoglycemia; Male; Ondansetron; Seizures; Serotoni

2011
Acute dystonic reaction to general anesthesia with propofol and ondansetron: a graded response.
    Ear, nose, & throat journal, 2013, Volume: 92, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Antiemetics; Dystonia; Female; Humans; Ondanse

2013
Ondansetron-induced multifocal encephalopathy.
    Mayo Clinic proceedings, 2003, Volume: 78, Issue:9

    Topics: Antiemetics; Brain Diseases; Dystonia; Female; Hand; Humans; Mandible; Middle Aged; Mouth; Ocular Mo

2003
Dystonic reaction following anaesthesia.
    Anaesthesia, 2004, Volume: 59, Issue:7

    Topics: Adult; Anesthesia, Dental; Anesthesia, General; Antiemetics; Dystonia; Female; Humans; Ondansetron;

2004
Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.
    The Journal of emergency medicine, 2006, Volume: 30, Issue:3

    Topics: Administration, Topical; Adult; Antiemetics; Dexamethasone; Dopamine Antagonists; Dystonia; Emergenc

2006
Ondansetron and carpopedal spasm.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2008, Volume: 55, Issue:1

    Topics: Adult; Diagnosis, Differential; Dystonia; Female; Hand; Humans; Hyperventilation; Leg; Muscle Rigidi

2008
Dystonic reaction after anesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:1

    Topics: Adult; Anesthesia; Anesthetics, Intravenous; Antiemetics; Dystonia; Female; Humans; Ondansetron; Pro

2001