ondansetron and Complication, Intraoperative studies

Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Research Excerpts

Excerpt	Relevance	Reference
"Ondansetron was effectively used to prevent spinal anesthesia-induced hypotension in the general population and women anesthetised for cesarean section."	5.20	Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. ( Dylczyk-Sommer, A; Jasiński, T; Marciniak, A; Owczuk, R; Polak-Krzemińska, A; Sawicka, W; Twardowski, P; Wenski, W; Wujtewicz, M; Wujtewicz, MA, 2015)
"To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone."	5.17	Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. ( Allen, TK; George, RB; Habib, AS; Ituk, US; McKeen, DM; Megalla, SA; White, WD, 2013)
"While interventions such as crystalloids, colloids, ephedrine, phenylephrine, ondansetron, or lower leg compression can reduce the incidence of hypotension, none have been shown to eliminate the need to treat maternal hypotension in some women."	5.05	Techniques for preventing hypotension during spinal anaesthesia for caesarean section. ( Chemali, M; Chooi, C; Cox, JJ; Cyna, AM; Emmett, RS; Lumb, RS; Middleton, P; Simmons, SW, 2020)

Research

Studies (7)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Discharge on Postoperative Day #2

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (28.57)	18.2507
2000's	2 (28.57)	29.6817
2010's	2 (28.57)	24.3611
2020's	1 (14.29)	2.80

Authors	Studies
Chooi, C	1
Cox, JJ	1
Lumb, RS	1
Middleton, P	1
Chemali, M	1
Emmett, RS	1
Simmons, SW	1
Cyna, AM	1
Habib, AS	1
George, RB	1
McKeen, DM	1
White, WD	1
Ituk, US	1
Megalla, SA	1
Allen, TK	1
Owczuk, R	1
Wenski, W	1
Twardowski, P	1
Dylczyk-Sommer, A	1
Sawicka, W	1
Wujtewicz, MA	1
Marciniak, A	1
Polak-Krzemińska, A	1
Jasiński, T	1
Wujtewicz, M	1
Fernando, SL	1
Broadfoot, AJ	1
Janeiro, M	1
Camblor, E	1
Fernández, R	1
Núñez, D	1
Ross, AK	1
Ferrero-Conover, D	1
Abouleish, EI	1
Rashid, S	1
Haque, S	1
Giezentanner, A	1
Joynton, P	1
Chuang, AZ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of the Efficacy of 6% Hydroxyethyl Starch (HES, 130/0.4) in Normal Saline Compared to Ringer's Lactate Solution for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section[NCT00694343]	Phase 4	167 participants (Actual)	Interventional	2008-06-30	Completed
The Time Required to Remain Sitting After Spinal Anesthesia for 50% of Patients to Not Experience Hypotension[NCT01561274]	Phase 2	50 participants (Actual)	Interventional	2012-03-31	Completed
The Oxygenation of the Brain During Caesarean Section. A Comparison of Ephedrine Versus Phenylephrine[NCT01509521]	Phase 4	24 participants (Anticipated)	Interventional	2012-02-29	Completed
Electrical Acupoint Stimulation Alleviates Hypotension After Spinal Anesthesia in Parturients: a Prospective Randomized Controlled Clinical Trial[NCT05724095]		90 participants (Actual)	Interventional	2023-02-20	Completed
Enhanced Recovery at Cesarean Birth to Improve Postoperative Outcomes and Reduce Postoperative Length of Stay[NCT02956616]	Phase 2	118 participants (Actual)	Interventional	2017-09-01	Completed
The Effect of Adding Metoclopramide and Ondansetron to a Prophylactic Phenylephrine Infusion for the Management of Nausea and Vomiting Associated With Spinal Anesthesia for Cesarean Section[NCT01216410]		306 participants (Actual)	Interventional	2008-12-31	Completed
Randomized Double Control Study to Assess the Efficacy of Administering 1 ml of Glycopyrrolate With the Spinal Dose in Minimizing Nausea and Vomiting in Patients Undergoing Cesarean Section Under Spinal Anesthesia[NCT02872935]	Phase 4	22 participants (Actual)	Interventional	2015-05-15	Terminated
IRB-HSR# 14583: Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients[NCT01414777]	Phase 2/Phase 3	68 participants (Actual)	Interventional	2009-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of patients discharged on postoperative Day #2 (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Postoperative Length of Hospital Stay

Intervention	Participants (Count of Participants)
Enhanced Recovery	5
Routine Perioperative Care	2

Postoperative Length of Hospital Stay in Hours from time of surgery (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Postoperative Pain Medication Requirement

Intervention	Hours (Median)
Enhanced Recovery	73.58
Routine Perioperative Care	75.50

The amount of postoperative pain medication required for each patient in Morphine Milligram Equivalents (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Breastfeeding Initiation

Intervention	Morphine Milligram Equivalents (Mean)
Enhanced Recovery	117.16
Routine Perioperative Care	119.38

All patients will be queried regarding whether breastfeeding was initiated after cesarean birth and how soon after birth (NCT02956616)
Timeframe: Until patient's day of hospital discharge or a maximum of one month from cesarean delivery

Intraoperative Nausea and Vomiting

Intervention	Participants (Count of Participants)
	Breastfeeding	Bottlefeeding	Both Breastfeeding and Bottlefeeding
Enhanced Recovery	39	4	15
Routine Perioperative Care	29	2	29

Comparison of intraoperative nausea and vomiting between the 3 groups. (NCT01216410)
Timeframe: Intraoperatively

Maternal Hemodynamics

Intervention	participants (Number)
Combination Group	23
Metoclopramide	31
Phenylephrine Infusion	49

The number of patients with systolic blood pressure decrease to less than 20 % of baseline intraoperatively (NCT01216410)
Timeframe: Intraoperatively

Pruritus

Satisfaction

Intervention	participants with SBP< 20 % baseline (Number)
Combination Group	16
Metoclopramide	19
Phenylephrine Infusion	16

Intervention	participants (Number)
Combination Group	95
Metoclopramide	93
Phenylephrine Infusion	97

1=very satisfied, 2=somewhat satisfied, 3= neither satisfied nor dissatisfied, 4=somewhat dissatisfied, 5= very dissatisfied. Number of very satisfied subjects posted. (NCT01216410)
Timeframe: 24 h

Postoperative Nausea and Vomiting (PONV)

Number of Participants Who Experienced Vomiting.

Intervention	participants (Number)
Combination Group	94
Metoclopramide	85
Phenylephrine Infusion	87

Intervention	participants (Number)
	0-2 hrs PONV	2-6 hrs PONV	6-24 hrs PONV
Combination Group	20	28	22
Metoclopramide	33	35	26
Phenylephrine Infusion	39	41	22

This measure is observed by care team. Reported as vomiting, yes or no. (NCT02872935)
Timeframe: From the administration of the spinal anesthesia to delivery of baby; Total time 90minutes

Number of Participants Who Reported Nausea

Intervention	Participants (Count of Participants)
Placebo: Normal Saline	4
Glycopyrrolate Group	2

Did the subject report nausea? The subject will respond with yes or no. (NCT02872935)
Timeframe: From the administration of the spinal anesthesia to delivery of baby - Total time 90minutes

Article	Year
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020
Techniques for preventing hypotension during spinal anaesthesia for caesarean section. The Cochrane database of systematic reviews, 2020, 07-01, Volume: 7 Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Colloids; Crystalloid So	2020

Article	Year
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstetrics and gynecology, 2013, Volume: 121, Issue:3 Topics: Adult; Anesthesia, Spinal; Antiemetics; Cardiotonic Agents; Cesarean Section; Drug Therapy, Combinat	2013
Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. Minerva anestesiologica, 2015, Volume: 81, Issue:6 Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Antiemetics; Blood Pressure; Double-Blind Method; Femal	2015
Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia. Anaesthesia, 1999, Volume: 54, Issue:5 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Double-Blind Meth	1999
Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia. Anaesthesia, 1999, Volume: 54, Issue:5 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Double-Blind Meth	1999
Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia. Anaesthesia, 1999, Volume: 54, Issue:5 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Double-Blind Meth	1999
Ondansetron versus placebo for the control of nausea and vomiting during Caesarean section under spinal anaesthesia. Anaesthesia, 1999, Volume: 54, Issue:5 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Section; Double-Blind Meth	1999

Article	Year
Ondansetron anaphylaxis: a case report and protocol for skin testing. British journal of anaesthesia, 2009, Volume: 102, Issue:2 Topics: Adult; Anaphylaxis; Antiemetics; Female; Humans; Hypotension; Intraoperative Complications; Ondanset	2009
[Narcolepsy and anesthesia]. Revista espanola de anestesiologia y reanimacion, 2007, Volume: 54, Issue:3 Topics: Analgesia, Epidural; Anesthesia, Intravenous; Antiemetics; Benzhydryl Compounds; Chemical and Drug I	2007
Anaphylactoid reaction due to the administration of ondansetron in a pediatric neurosurgical patient. Anesthesia and analgesia, 1998, Volume: 87, Issue:4 Topics: Anaphylaxis; Antiemetics; Child; Cranial Fossa, Posterior; Drug Hypersensitivity; Female; Humans; In	1998

ondansetron and Complication, Intraoperative