ondansetron has been researched along with Asystole in 3 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To present a case of asystole during spinal anesthesia that responded to atropine and ondansetron and to discuss the possible pathophysiology with special emphasis on the Bezold-Jarisch reflex and the role of 5-HT3 receptors in mediating bradycardia and sympathoinhibition." | 7.72 | Witnessed asystole during spinal anesthesia treated with atropine and ondansetron: a case report. ( Martinek, RM, 2004) |
| "Ondansetron is commonly used to treat vomiting in gastroenteritis, but has a United States Food and Drug Administration black box warning for risk of Q wave to T wave time interval (QT) prolongation." | 3.83 | Fatal Cardiac Arrest in 2 Children: Possible Role of Ondansetron. ( Boucher, J; Brenner, SM, 2016) |
| "To present a case of asystole during spinal anesthesia that responded to atropine and ondansetron and to discuss the possible pathophysiology with special emphasis on the Bezold-Jarisch reflex and the role of 5-HT3 receptors in mediating bradycardia and sympathoinhibition." | 3.72 | Witnessed asystole during spinal anesthesia treated with atropine and ondansetron: a case report. ( Martinek, RM, 2004) |
| "Ondansetron is a commonly used antiemetic in the emergency department despite a 2011 FDA warning regarding dose-related QTc prolongation and torsades des pointes (TdP)." | 1.91 | QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron. ( Cole, JB; Fuchs, RT; Fushianes, GD; Lee, SC; Orozco, BS, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Orozco, BS | 1 |
| Lee, SC | 1 |
| Fuchs, RT | 1 |
| Fushianes, GD | 1 |
| Cole, JB | 1 |
| Brenner, SM | 1 |
| Boucher, J | 1 |
| Martinek, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IRB-HSR# 14583: Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients[NCT01414777] | Phase 2/Phase 3 | 68 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for ondansetron and Asystole
| Article | Year |
|---|---|
QT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron.
Topics: Adult; Antiemetics; DNA-Binding Proteins; Electrocardiography; Female; Heart Arrest; Humans; Long QT | 2023 |
Fatal Cardiac Arrest in 2 Children: Possible Role of Ondansetron.
Topics: Child; Fatal Outcome; Gastroenteritis; Heart Arrest; Humans; Infant; Male; Ondansetron; United State | 2016 |
Witnessed asystole during spinal anesthesia treated with atropine and ondansetron: a case report.
Topics: Anesthesia, Spinal; Atropine; Drug Therapy, Combination; Heart Arrest; Humans; Male; Middle Aged; On | 2004 |