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ondansetron and Air Sickness

ondansetron has been researched along with Air Sickness in 16 studies

Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Research Excerpts

ExcerptRelevanceReference
"A prospective randomized study was performed to assess the value of some individual risk factors for postoperative nausea and vomiting (PONV), and to compare the efficacy of ondansetron, metoclopramide, dexamethason, and combinations of these antiemetics in preventing PONV in patients after laparoscopic cholecystectomy."9.12Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study. ( Leksowski, K; Peryga, P; Szyca, R, 2006)
"Ondansetron is currently being explored as a treatment for motion sickness due to its proven prophylactic effect on post-operative nausea, the nausea and vomiting associated with chemotherapy, and its lack of side effects."9.12High dose ondansetron for reducing motion sickness in highly susceptible subjects. ( Elkins, AN; Muth, ER, 2007)
"To determine (1) the efficacy and safety of ondansetron in the prevention of postoperative nausea and vomiting (PONV) in male outpatients; (2) prognostic factors for PONV in male outpatients; and (3) patients' perceptions of the debilitating effects of PONV in the ambulatory surgery setting."9.08Ondansetron prevents postoperative emesis in male outpatients. S3A-379 Study Group. ( Cox, F; Joslyn, AF; Khalil, SN; Kovac, AL; Pearman, MH; Prillaman, BA; Scuderi, PE, 1996)
" This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model."9.08Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997)
"We studied the efficacy and safety of intravenous ondansetron 4 mg for the prevention of postoperative nausea and vomiting after minor gynaecological laparoscopic surgery in Oriental women."9.07Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery. ( Chen, PP; Critchley, LA; Gin, TA; Ray, AK; Rowbottom, YM; Suen, TK, 1994)
"The post-operative anti-emetic efficacy of 4 and 8 mg of ondansetron in adult patients with and without a previous history of motion sickness (PHMS) was assessed by meta-analysis."8.80Prophylactic ondansetron for post-operative emesis: meta-analysis of its effectiveness in patients with and without a previous history of motion sickness. ( Canosa, L; Figueredo, E, 1999)
"The meclizine group had lower VNRS scores in the PACU at 15 (P = ."6.73Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. ( Benfield, DA; Forrester, CM; Kelly, JA; Matern, CE; Pellegrini, JE, 2007)
"The exact incidence of postoperative nausea and vomiting (PONV) in patients on steroids undergoing neurosurgical procedures is not known."6.73Effect of prophylactic ondansetron on postoperative nausea and vomiting in patients on preoperative steroids undergoing craniotomy for supratentorial tumors. ( Chandrashekharappa, KN; Mukherjee, KK; Nakra, D; Wig, J; Yaddanapudi, LN, 2007)
" The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist."6.69Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man. ( Clemes, SA; House, F; Palmer, JL; Reid, K; Somal, HS; Stott, JR; Troakes, C; Wright, RJ, 2000)
"A prospective randomized study was performed to assess the value of some individual risk factors for postoperative nausea and vomiting (PONV), and to compare the efficacy of ondansetron, metoclopramide, dexamethason, and combinations of these antiemetics in preventing PONV in patients after laparoscopic cholecystectomy."5.12Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study. ( Leksowski, K; Peryga, P; Szyca, R, 2006)
"Ondansetron is currently being explored as a treatment for motion sickness due to its proven prophylactic effect on post-operative nausea, the nausea and vomiting associated with chemotherapy, and its lack of side effects."5.12High dose ondansetron for reducing motion sickness in highly susceptible subjects. ( Elkins, AN; Muth, ER, 2007)
"The purpose of this study was to determine the effects of the serotonin (5-HT3) receptor-antagonist antiemetics ondansetron and granisetron on the development of gastric tachyarrhythmia, nausea, and other symptoms of motion sickness."5.09The effects of serotonin (5-HT3) receptor antagonists on gastric tachyarrhythmia and the symptoms of motion sickness. ( Chillas, JC; Knox, GW; Levine, ME; Stern, RM, 2000)
"To determine (1) the efficacy and safety of ondansetron in the prevention of postoperative nausea and vomiting (PONV) in male outpatients; (2) prognostic factors for PONV in male outpatients; and (3) patients' perceptions of the debilitating effects of PONV in the ambulatory surgery setting."5.08Ondansetron prevents postoperative emesis in male outpatients. S3A-379 Study Group. ( Cox, F; Joslyn, AF; Khalil, SN; Kovac, AL; Pearman, MH; Prillaman, BA; Scuderi, PE, 1996)
" This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model."5.08Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997)
"We studied the efficacy and safety of intravenous ondansetron 4 mg for the prevention of postoperative nausea and vomiting after minor gynaecological laparoscopic surgery in Oriental women."5.07Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery. ( Chen, PP; Critchley, LA; Gin, TA; Ray, AK; Rowbottom, YM; Suen, TK, 1994)
"The post-operative anti-emetic efficacy of 4 and 8 mg of ondansetron in adult patients with and without a previous history of motion sickness (PHMS) was assessed by meta-analysis."4.80Prophylactic ondansetron for post-operative emesis: meta-analysis of its effectiveness in patients with and without a previous history of motion sickness. ( Canosa, L; Figueredo, E, 1999)
"Seasickness is a common problem, causing a significant decrement in performance among naval crew."2.74Ondansetron for the prevention of seasickness in susceptible sailors: an evaluation at sea. ( Asna, N; Bar, R; Hershkovitz, D; Kaminski, G; Shupak, A; Tal, D, 2009)
"The meclizine group had lower VNRS scores in the PACU at 15 (P = ."2.73Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. ( Benfield, DA; Forrester, CM; Kelly, JA; Matern, CE; Pellegrini, JE, 2007)
"The exact incidence of postoperative nausea and vomiting (PONV) in patients on steroids undergoing neurosurgical procedures is not known."2.73Effect of prophylactic ondansetron on postoperative nausea and vomiting in patients on preoperative steroids undergoing craniotomy for supratentorial tumors. ( Chandrashekharappa, KN; Mukherjee, KK; Nakra, D; Wig, J; Yaddanapudi, LN, 2007)
" The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist."2.69Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man. ( Clemes, SA; House, F; Palmer, JL; Reid, K; Somal, HS; Stott, JR; Troakes, C; Wright, RJ, 2000)
"Pretreatment with ondansetron, a serotonin 5-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%."1.40Thermoregulatory correlates of nausea in rats and musk shrews. ( Cerri, M; Corrigan, JJ; Del Vecchio, F; Dragic, AS; Kamphee, A; Nalivaiko, E; Ngampramuan, S; Romanovsky, AA; Rudd, JA, 2014)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's5 (31.25)18.2507
2000's7 (43.75)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ngampramuan, S1
Cerri, M1
Del Vecchio, F1
Corrigan, JJ1
Kamphee, A1
Dragic, AS1
Rudd, JA1
Romanovsky, AA1
Nalivaiko, E1
Banting, J1
Meriano, T1
Hershkovitz, D1
Asna, N1
Shupak, A1
Kaminski, G1
Bar, R1
Tal, D1
Sutton, M1
Mounsey, AL1
Russell, RG1
Leksowski, K1
Peryga, P1
Szyca, R1
Forrester, CM1
Benfield, DA1
Matern, CE1
Kelly, JA1
Pellegrini, JE1
Muth, ER1
Elkins, AN1
Wig, J1
Chandrashekharappa, KN1
Yaddanapudi, LN1
Nakra, D1
Mukherjee, KK1
Suen, TK1
Gin, TA1
Chen, PP1
Rowbottom, YM1
Critchley, LA1
Ray, AK1
Kovac, AL1
Pearman, MH1
Khalil, SN1
Scuderi, PE1
Joslyn, AF1
Prillaman, BA1
Cox, F1
Polati, E1
Verlato, G1
Finco, G1
Mosaner, W1
Grosso, S1
Gottin, L1
Pinaroli, AM1
Ischia, S1
Benline, TA1
French, J1
Poole, E1
Figueredo, E1
Canosa, L1
Reid, K1
Palmer, JL1
Wright, RJ2
Clemes, SA1
Troakes, C1
Somal, HS1
House, F1
Stott, JR2
Levine, ME1
Chillas, JC1
Stern, RM1
Knox, GW1
Barnes, GR1
Ruddock, CJ1

Reviews

3 reviews available for ondansetron and Air Sickness

ArticleYear
Sea State Green.
    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2016,summer, Volume: 16, Issue:2

    Topics: Acupressure; Antiemetics; Cholinergic Antagonists; Dopamine Antagonists; Emergency Medical Technicia

2016
FPIN's Clinical Inquiries. Treatment of motion sickness.
    American family physician, 2012, Jul-15, Volume: 86, Issue:2

    Topics: Antiemetics; Cholinergic Antagonists; Histamine Antagonists; Humans; Motion Sickness; Ondansetron; P

2012
Prophylactic ondansetron for post-operative emesis: meta-analysis of its effectiveness in patients with and without a previous history of motion sickness.
    European journal of anaesthesiology, 1999, Volume: 16, Issue:8

    Topics: Antiemetics; Humans; MEDLINE; Motion Sickness; Ondansetron; Postoperative Nausea and Vomiting

1999

Trials

12 trials available for ondansetron and Air Sickness

ArticleYear
Ondansetron for the prevention of seasickness in susceptible sailors: an evaluation at sea.
    Aviation, space, and environmental medicine, 2009, Volume: 80, Issue:7

    Topics: Adolescent; Adult; Cognition; Cross-Over Studies; Double-Blind Method; Female; Humans; Israel; Male;

2009
Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study.
    Surgical endoscopy, 2006, Volume: 20, Issue:6

    Topics: Adult; Aged; Antiemetics; Cholecystectomy, Laparoscopic; Dexamethasone; Drug Therapy, Combination; F

2006
Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population.
    AANA journal, 2007, Volume: 75, Issue:1

    Topics: Adult; Drug Therapy, Combination; Elective Surgical Procedures; Female; Humans; Male; Meclizine; Mid

2007
High dose ondansetron for reducing motion sickness in highly susceptible subjects.
    Aviation, space, and environmental medicine, 2007, Volume: 78, Issue:7

    Topics: Adolescent; Adult; Analysis of Variance; Antiemetics; Dimenhydrinate; Disease Susceptibility; Dose-R

2007
Effect of prophylactic ondansetron on postoperative nausea and vomiting in patients on preoperative steroids undergoing craniotomy for supratentorial tumors.
    Journal of neurosurgical anesthesiology, 2007, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Inhalation; Antiemetics; Craniotomy; Double-Blind Method; Female; Hum

2007
Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery.
    Anaesthesia and intensive care, 1994, Volume: 22, Issue:2

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Double-Blind Method; Female; Follow-Up Studi

1994
Ondansetron prevents postoperative emesis in male outpatients. S3A-379 Study Group.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:8

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, General; Antiemetics;

1996
Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Antiemet

1997
Anti-emetic drug effects on pilot performance: granisetron vs. ondansetron.
    Aviation, space, and environmental medicine, 1997, Volume: 68, Issue:11

    Topics: Administration, Oral; Adult; Aerospace Medicine; Affect; Antiemetics; Attention; Cross-Over Studies;

1997
Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.
    British journal of clinical pharmacology, 2000, Volume: 50, Issue:1

    Topics: Adolescent; Adult; Antiemetics; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination;

2000
The effects of serotonin (5-HT3) receptor antagonists on gastric tachyarrhythmia and the symptoms of motion sickness.
    Aviation, space, and environmental medicine, 2000, Volume: 71, Issue:11

    Topics: Adolescent; Adult; Antiemetics; Cross-Over Studies; Double-Blind Method; Electrodiagnosis; Female; G

2000
The effect on motion sickness and oculomotor function of GR 38032F, a 5-HT3-receptor antagonist with anti-emetic properties.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Antiemetics; Clinical Trials as Topic; Double-Blind Method; Electrooculography; E

1989

Other Studies

1 other study available for ondansetron and Air Sickness

ArticleYear
Thermoregulatory correlates of nausea in rats and musk shrews.
    Oncotarget, 2014, Mar-30, Volume: 5, Issue:6

    Topics: Animals; Body Temperature Regulation; Feeding Behavior; Hypothermia; Male; Motion Sickness; Nausea;

2014