Page last updated: 2024-11-01

ondansetron and Aging

ondansetron has been researched along with Aging in 5 studies

Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The role of peripheral 5-HT3 receptors in the nociceptive behavioral response and the effect of the 5-HT3 antagonist ondansetron on indices of acute and tonic pain were investigated in the formalin test in 25- and 90-day-old Wistar male rats."3.74[Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress]. ( Butkevich, IP; Makukhina, GV; Mikhaĭlenko, VA, 2007)
"Ondansetron was well tolerated by all age groups with no increase in the number of adverse events observed in older volunteers."2.67Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers. ( Benedetti, TL; Bryson, JC; Kernodle, AE; Powell, JR; Pritchard, JF, 1992)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alzoubi, KH1
Aleisa, AM1
Alkadhi, KA1
Butkevich, IP1
Mikhaĭlenko, VA1
Makukhina, GV1
Pritchard, JF1
Bryson, JC1
Kernodle, AE1
Benedetti, TL1
Powell, JR1
Riekkinen, P2
Sirviö, J1
Barnes, JM1
Costall, B1
Coughlan, J1
Domeney, AM1
Gerrard, PA1
Kelly, ME1
Naylor, RJ1
Onaivi, ES1
Tomkins, DM1
Tyers, MB1

Trials

1 trial available for ondansetron and Aging

ArticleYear
Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Evaluation Studies as Topic; Female; Hu

1992

Other Studies

4 other studies available for ondansetron and Aging

ArticleYear
In vivo expression of ganglionic long-term potentiation in superior cervical ganglia from hypertensive aged rats.
    Neurobiology of aging, 2010, Volume: 31, Issue:5

    Topics: Aging; Animals; Blood Pressure; Blotting, Western; Calcineurin; Calcium-Calmodulin-Dependent Protein

2010
[Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2007, Volume: 93, Issue:2

    Topics: Aging; Analgesics; Animals; Female; Inflammation; Male; Ondansetron; Pain; Phenylalanine; Pregnancy;

2007
Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Aging; Alanine; Animals; Antidepressive Agents; Electroencephalography; Electrophysiology; Imidazole

1991
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: Aging; Animals; Arecoline; Brain; Callithrix; Choline O-Acetyltransferase; Cognition; Female; Habitu

1990