omeprazole has been researched along with Vitamin B 12 Deficiency in 14 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Vitamin B 12 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 38-year-old Caucasian man with mild hypertension and no other significant medical history developed profound erectile dysfunction within 2 days of initiating over-the-counter omeprazole therapy, with erectile function rapidly normalizing following discontinuation of the drug." | 8.02 | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report. ( Perry, TW, 2021) |
| "A 38-year-old Caucasian man with mild hypertension and no other significant medical history developed profound erectile dysfunction within 2 days of initiating over-the-counter omeprazole therapy, with erectile function rapidly normalizing following discontinuation of the drug." | 4.02 | Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report. ( Perry, TW, 2021) |
| "A 78-year-old nonvegetarian white woman with symptomatic gastroesophageal reflux (GER) was started on cimetidine 300 mg 4 times daily in February 1990 and took various other antisecretory medications over the course of the next 4 1/2 years." | 3.71 | Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor. ( Page, RL; Ruscin, JM; Valuck, RJ, 2002) |
| "As chronic use of antiulcer medications might predispose older persons to cobalamin deficiency, we studied participants (> 65 years) in the clinical examination of the Canadian Study of Health and Aging to test the association between the use of an antiulcer medication (histamine-2 blocker or proton pump inhibitor) at baseline with initiation of cobalamin replacement during the 5 year follow-up period." | 1.31 | The association between antiulcer medication and initiation of cobalamin replacement in older persons. ( Mitchell, SL; Rockwood, K, 2001) |
| "H pylori was detected in the dental plaque with camphylobacter-like organism test gels." | 1.31 | The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B12-deficiency anemia. ( Avcu, F; Avcu, N; Beyan, C; Kaptan , K; Nevruz, O; Ozyurt, M; Ural, AU; Yalçin, A, 2001) |
| "Whether such treatment will result in vitamin B12 deficiency is controversial." | 1.30 | Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. ( Gibril, F; Jensen, RT; Sutliff, VE; Termanini, B; Venzon, DJ; Yu, F, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Rehmani, A | 1 |
| Mehta, I | 1 |
| Siu, NY | 1 |
| Smith, E | 1 |
| Perry, TW | 1 |
| Reimer, C | 1 |
| Bytzer, P | 1 |
| Hershko, C | 1 |
| Hoffbrand, AV | 1 |
| Keret, D | 1 |
| Souroujon, M | 1 |
| Maschler, I | 1 |
| Monselise, Y | 1 |
| Lahad, A | 1 |
| Raghunath, AS | 1 |
| O'Morain, C | 1 |
| McLoughlin, RC | 1 |
| Marcuard, SP | 1 |
| Albernaz, L | 1 |
| Khazanie, PG | 1 |
| Bellou, A | 1 |
| Aimone-Gastin, I | 1 |
| De Korwin, JD | 1 |
| Bronowicki, JP | 1 |
| Moneret-Vautrin, A | 1 |
| Nicolas, JP | 1 |
| Bigard, MA | 1 |
| Guéant, JL | 1 |
| Termanini, B | 1 |
| Gibril, F | 1 |
| Sutliff, VE | 1 |
| Yu, F | 1 |
| Venzon, DJ | 1 |
| Jensen, RT | 1 |
| Brieva, L | 1 |
| Ara, JR | 1 |
| Bertol, V | 1 |
| Canellas, A | 1 |
| del Agua, C | 1 |
| Bradford, GS | 1 |
| Taylor, CT | 1 |
| Mitchell, SL | 1 |
| Rockwood, K | 1 |
| Avcu, N | 1 |
| Avcu, F | 1 |
| Beyan, C | 1 |
| Ural, AU | 1 |
| Kaptan , K | 1 |
| Ozyurt, M | 1 |
| Nevruz, O | 1 |
| Yalçin, A | 1 |
| ter Heide, H | 1 |
| Hendriks, HJ | 1 |
| Heijmans, H | 1 |
| Menheere, PP | 1 |
| Spaapen, LJ | 1 |
| Bakker, JA | 1 |
| Forget, PP | 1 |
| Ruscin, JM | 1 |
| Page, RL | 1 |
| Valuck, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparing Omeprazole With Fluoxetine for Treatment of Non Erosive Reflux Disease and Its Subgroups: a Double-blind Placebo-controlled Clinical Trial[NCT01269788] | Phase 2/Phase 3 | 144 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis[NCT01524757] | 48 participants (Anticipated) | Interventional | 2012-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for omeprazole and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Review article: the long-term use of proton-pump inhibitors.
Topics: Age Factors; Enzyme Inhibitors; Gastritis, Atrophic; Gastroesophageal Reflux; Helicobacter Infection | 2005 |
Omeprazole and vitamin B12 deficiency.
Topics: Humans; Omeprazole; Vitamin B 12 Deficiency | 1999 |
1 trial available for omeprazole and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12)
Topics: Adult; Humans; Malabsorption Syndromes; Male; Middle Aged; Omeprazole; Protein Binding; Reference Va | 1994 |
11 other studies available for omeprazole and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Nutritional Optic Neuropathy From Chronic Omeprazole Use.
Topics: Adult; Contrast Sensitivity; Female; Gastroesophageal Reflux; Humans; Omeprazole; Optic Disk; Optic | 2021 |
Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report.
Topics: Adult; Aged; Enterocolitis, Pseudomembranous; Erectile Dysfunction; Humans; Male; Omeprazole; Proton | 2021 |
[Adverse events associated with long-term use of proton pump inhibitors].
Topics: Anti-Ulcer Agents; Bacterial Infections; Congenital Abnormalities; Dyspepsia; Fractures, Bone; Gastr | 2012 |
Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anemia, Iron-Deficiency; Antibodies, Bacterial; Autoantibodies | 2005 |
Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy.
Topics: Anemia, Megaloblastic; Enzyme Inhibitors; Gastroesophageal Reflux; Hematinics; Humans; Malabsorption | 1996 |
Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome.
Topics: Achlorhydria; Adenosine Triphosphatases; Adolescent; Adult; Aged; Anti-Ulcer Agents; Drug Monitoring | 1998 |
[Polyneuropathy caused by vitamin B12 deficiency secondary to chronic atrophic gastritis and giardiasis].
Topics: Amoxicillin; Anemia, Pernicious; Anti-Bacterial Agents; Antiprotozoal Agents; Bismuth; Duodenitis; E | 1998 |
The association between antiulcer medication and initiation of cobalamin replacement in older persons.
Topics: Aged; Anti-Ulcer Agents; Canada; Female; Histamine H2 Antagonists; Humans; Male; Omeprazole; Stomach | 2001 |
The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B12-deficiency anemia.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anemia, Pernicious; Anti-Bacterial Agents; Anti-Ulcer A | 2001 |
Are children with cystic fibrosis who are treated with a proton-pump inhibitor at risk for vitamin B(12) deficiency?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Case-Control Studies; Child; Child, Preschool; | 2001 |
Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor.
Topics: Aged; Cimetidine; Creatinine; Enzyme Inhibitors; Female; Folic Acid; Gastroesophageal Reflux; Histam | 2002 |