omeprazole has been researched along with Testicular Neoplasms in 2 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lansoprazole treatment produced effects on the liver consistent with an enhanced metabolic capacity, including significant increases in relative liver weights, total microsomal CYP content, individual CYP protein levels, and enhanced CYP-dependent testosterone metabolism in vitro." | 1.32 | Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis. ( Coulson, M; Gibson, GG; Graham, M; Hammond, T; Plant, N, 2003) |
| "Lansoprazole is a substituted benzimidazole which inhibits gastric acid secretion by inhibiting the hydrogen-potassium ATPase (proton pump) in the parietal cell." | 1.29 | Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole. ( Ando, T; Fort, FL; Hamashima, T; Hodgen, GD; Kitazaki, T; Mahony, MC; Miyajima, H; Sato, S; Suzuki, T; Yamamoto, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coulson, M | 1 |
| Gibson, GG | 1 |
| Plant, N | 1 |
| Hammond, T | 1 |
| Graham, M | 1 |
| Fort, FL | 1 |
| Miyajima, H | 1 |
| Ando, T | 1 |
| Suzuki, T | 1 |
| Yamamoto, M | 1 |
| Hamashima, T | 1 |
| Sato, S | 1 |
| Kitazaki, T | 1 |
| Mahony, MC | 1 |
| Hodgen, GD | 1 |
2 other studies available for omeprazole and Testicular Neoplasms
| Article | Year |
|---|---|
Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Chromatography, High Pressur | 2003 |
Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Carcinogens; Chorionic Gonadotropin; Dose-Response | 1995 |