Page last updated: 2024-11-01

omeprazole and Sleep Wake Disorders

omeprazole has been researched along with Sleep Wake Disorders in 5 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.

Research Excerpts

ExcerptRelevanceReference
"The effect of gastro-oesophageal reflux on sleep and sleep quality is highly controversial."5.33The effect of gastro-oesophageal reflux and omeprazole on key sleep parameters. ( Banwait, KS; Cohen, S; Dimarino, AJ; Dimarino, M; Doghramji, K; Eschinger, E; Greenberg, A, 2005)
"Rabeprazole treatment significantly improved subjective indices of sleep quality."2.71The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal reflux. ( Goodrich, S; Orr, WC; Robert, J, 2005)
"The consequences of nocturnal gastroesophageal reflux disease (GERD) may be greater than daytime GERD in terms of clinical complications such as increased risk of esophageal lesions and respiratory conditions, as well as issues of health-related quality of life, sleep, work productivity, and economics."2.44Nocturnal gastroesophageal reflux disease: issues, implications, and management strategies. ( Johnson, DA; Katz, PO, 2008)
"Acid reflux esophagitis was induced by ligating the transitional region between the forestomach and the glandular portion and then wrapping the duodenum near the pylorus."1.40Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. ( Arakawa, T; Fujiwara, Y; Nakahara, K; Shiba, M; Tanigawa, T; Tominaga, K; Tsukahara, T; Urade, Y; Watanabe, T; Yamagami, H, 2014)
"The effect of gastro-oesophageal reflux on sleep and sleep quality is highly controversial."1.33The effect of gastro-oesophageal reflux and omeprazole on key sleep parameters. ( Banwait, KS; Cohen, S; Dimarino, AJ; Dimarino, M; Doghramji, K; Eschinger, E; Greenberg, A, 2005)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakahara, K1
Fujiwara, Y1
Tsukahara, T1
Yamagami, H1
Tanigawa, T1
Shiba, M1
Tominaga, K1
Watanabe, T1
Urade, Y1
Arakawa, T1
Johnson, DA1
Katz, PO1
Orr, WC1
Goodrich, S1
Robert, J1
Dimarino, AJ1
Banwait, KS1
Eschinger, E1
Greenberg, A1
Dimarino, M1
Doghramji, K1
Cohen, S1
Huuhka, K1
Riutta, A1
Haataja, R1
Ylitalo, P1
Leinonen, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features in a Primary Care Setting: A Pragmatic, Randomized, Single Blind Study[NCT04028466]Phase 482 participants (Actual)Interventional2019-05-26Terminated (stopped due to Budget for the study was withdrawn and discontinued)
The Effect Of Pantoprazole 40 mg Once Daily Versus Placebo On The Power Spectral Analysis Of The Sleep Electroencephalogram (EEG) Of Patients With Gastroesophageal Reflux Disease (GERD)[NCT00674245]Phase 2/Phase 340 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for omeprazole and Sleep Wake Disorders

ArticleYear
Nocturnal gastroesophageal reflux disease: issues, implications, and management strategies.
    Reviews in gastroenterological disorders, 2008,Spring, Volume: 8, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Gastroesophageal Reflux; Heartburn; Humans; Lansoprazole; O

2008

Trials

2 trials available for omeprazole and Sleep Wake Disorders

ArticleYear
The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal reflux.
    Alimentary pharmacology & therapeutics, 2005, Jan-15, Volume: 21, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Antacids; Anti-Ulcer Agents; Benzimidazoles; Female;

2005
The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.
    Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:7

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Ag

2006

Other Studies

2 other studies available for omeprazole and Sleep Wake Disorders

ArticleYear
Acid reflux directly causes sleep disturbances in rat with chronic esophagitis.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Chronic Disease; Esophagitis, Peptic; Esophagus; Gastric Acid; Gastric Juice; Gastroesophag

2014
The effect of gastro-oesophageal reflux and omeprazole on key sleep parameters.
    Alimentary pharmacology & therapeutics, 2005, 08-15, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Anti-Ulcer Agents; Case-Control Studies; Female; Gastroesophageal Reflux; Humans;

2005
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