omeprazole has been researched along with Precancerous Conditions in 31 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients undergoing long-term treatment with omeprazole, tiny gastric polyps, described histologically as glandular cysts, have occasionally been reported." | 7.69 | Observation of gastric glandular cysts in the corpus mucosa of the stomach under omeprazole treatment. ( Armbrecht, U; Bethke, B; Goldbrunner, P; Lütke, A; Rabast, U; Seifert, E; Stolte, M, 1995) |
| "In this double-blind study, patients with precancerous gastric dysplasia with or without intestinal metaplasia (IM) received either conventional treatment consisting of omeprazole and sucralfate (control group) or conventional treatment plus ATRA." | 5.20 | Addition of all-trans-retinoic acid to omeprazole and sucralfate therapy improves the prognosis of gastric dysplasia. ( Bai, Y; Chang, Y; Gao, Q; Jiang, Y; Jin, J; Jin, Z; Li, X; Lu, L; Su, X; Wu, L; Xing, L; Zhao, X; Zheng, Y, 2015) |
| "In patients undergoing long-term treatment with omeprazole, tiny gastric polyps, described histologically as glandular cysts, have occasionally been reported." | 3.69 | Observation of gastric glandular cysts in the corpus mucosa of the stomach under omeprazole treatment. ( Armbrecht, U; Bethke, B; Goldbrunner, P; Lütke, A; Rabast, U; Seifert, E; Stolte, M, 1995) |
| "Here we report 14." | 2.77 | Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. ( Blot, WJ; Brown, LM; Crystal-Mansour, S; Fraumeni, JF; Gail, MH; Han, ZX; Hu, Y; Li, JY; Liu, WD; Ma, JL; Pan, KF; Pee, D; Shen, L; You, WC; Zhang, L, 2012) |
| "Among the 18 new cases of gastric cancers that developed, no overall reduction was observed in participants who received H pylori eradication treatment (n = 7) compared with those who did not (n = 11) (P =." | 2.71 | Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. ( Chen, JS; Ching, CK; Feng, RE; Fong, DY; Ho, J; Hu, WH; Lai, KC; Lam, SK; Leung, SY; Wong, BC; Wong, WM; Yuen, ST; Zheng, TT, 2004) |
| "pylori at 6 wk were infected at 1 yr (recurrence rates 10." | 2.70 | Eradication rate of Helicobacter pylori in a Mexican population at high risk for gastric cancer and use of serology to assess cure. ( Figueroa, LS; Guarner, J; Halperin, D; Herrera-Goepfert, R; Ley, C; Mohar, A; Parsonnet, J, 2002) |
| "Gastric cancer is the second most frequent cause of death from cancer in the world and the leading cause of death from cancer in China." | 2.70 | An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity. ( Brown, LM; Chang, YS; Fraumeni, JF; Gail, MH; Heinrich, J; Liu, WD; Ma, JL; Xu, GW; Yang, CS; You, WC; Zhang, L, 2001) |
| "KTP laser destruction of Barrett's esophagus induced mucosal regeneration with normal squamous cell epithelium in combination with acid suppression." | 2.69 | KTP laser destruction of dysplasia and early cancer in columnar-lined Barrett's esophagus. ( Ell, C; Gossner, L; Hahn, EG; May, A; Seitz, G; Stolte, M, 1999) |
| "pylori-induced gastric cancer, irrespective of the timing of antibiotic administration." | 1.42 | Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model. ( Aponte-Pieras, JR; Lee, DS; Morrissey, R; Moss, SF; Rogers, AB; Zhang, S, 2015) |
| "Omeprazole treatment in human colon cancer cell lines HCT-116 and HCA-7 cells resulted in induction of p21waf1/cip1 and decreased the expression of anti-apoptotic proteins Bcl-2, Bcl-XL and survivin in a dose-dependent manner." | 1.38 | Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats. ( Li, Q; Patlolla, JM; Rao, CV; Steele, VE; Zhang, Y, 2012) |
| "pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions." | 1.35 | Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. ( Fox, JG; Ge, Z; Lee, CW; Rickman, B; Rogers, AB; Wang, TC, 2008) |
| "Endoscopy after ER detected no new gastric cancers in these patients." | 1.30 | Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. ( Haruma, K; Kajiyama, G; Mashiba, H; Mukai, T; Okamoto, S; Sasaki, N; Sumii, K; Taniyama, K; Uemura, N; Yamaguchi, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (25.81) | 18.2507 |
| 2000's | 15 (48.39) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WQ | 1 |
| Ma, JL | 7 |
| Zhang, L | 7 |
| Brown, LM | 5 |
| Li, JY | 6 |
| Shen, L | 4 |
| Pan, KF | 5 |
| Liu, WD | 6 |
| Hu, Y | 3 |
| Han, ZX | 2 |
| Crystal-Mansour, S | 3 |
| Pee, D | 3 |
| Blot, WJ | 4 |
| Fraumeni, JF | 5 |
| You, WC | 7 |
| Gail, MH | 5 |
| Jin, J | 1 |
| Li, X | 1 |
| Xing, L | 1 |
| Chang, Y | 1 |
| Wu, L | 1 |
| Jin, Z | 1 |
| Su, X | 1 |
| Bai, Y | 1 |
| Zheng, Y | 1 |
| Jiang, Y | 1 |
| Zhao, X | 1 |
| Lu, L | 1 |
| Gao, Q | 1 |
| Zhang, S | 1 |
| Lee, DS | 1 |
| Morrissey, R | 1 |
| Aponte-Pieras, JR | 1 |
| Rogers, AB | 2 |
| Moss, SF | 1 |
| Zhang, Y | 2 |
| Zhou, T | 1 |
| Lord, RV | 1 |
| Wong, BC | 2 |
| Feng, GS | 1 |
| Zhang, XD | 1 |
| Li, J | 1 |
| Lu, AP | 1 |
| Xia, HH | 1 |
| Lam, S | 1 |
| Patlolla, JM | 1 |
| Li, Q | 1 |
| Steele, VE | 1 |
| Rao, CV | 1 |
| Mohar, A | 1 |
| Ley, C | 1 |
| Guarner, J | 1 |
| Herrera-Goepfert, R | 1 |
| Figueroa, LS | 1 |
| Halperin, D | 1 |
| Parsonnet, J | 1 |
| Barr, H | 3 |
| Overholt, BF | 3 |
| Panjehpour, M | 2 |
| Halberg, DL | 1 |
| Lam, SK | 1 |
| Wong, WM | 1 |
| Chen, JS | 2 |
| Zheng, TT | 1 |
| Feng, RE | 1 |
| Lai, KC | 1 |
| Hu, WH | 1 |
| Yuen, ST | 1 |
| Leung, SY | 1 |
| Fong, DY | 1 |
| Ho, J | 1 |
| Ching, CK | 1 |
| Leung, WK | 1 |
| Lin, SR | 1 |
| Ching, JY | 1 |
| To, KF | 1 |
| Ng, EK | 1 |
| Chan, FK | 1 |
| Lau, JY | 1 |
| Sung, JJ | 1 |
| Jin, ML | 2 |
| Chang, YS | 3 |
| Xu, GW | 3 |
| Wang, KK | 1 |
| Burdick, JS | 1 |
| Lightdale, CJ | 1 |
| Kimmey, M | 1 |
| Nava, HR | 1 |
| Sivak, MV | 1 |
| Nishioka, N | 1 |
| Marcon, N | 1 |
| Pedrosa, M | 1 |
| Bronner, MP | 1 |
| Grace, M | 1 |
| Depot, M | 1 |
| Lee, CW | 1 |
| Rickman, B | 1 |
| Ge, Z | 1 |
| Wang, TC | 1 |
| Fox, JG | 1 |
| Stolte, M | 2 |
| Bethke, B | 1 |
| Seifert, E | 1 |
| Armbrecht, U | 1 |
| Lütke, A | 1 |
| Goldbrunner, P | 1 |
| Rabast, U | 1 |
| Fuchs, KH | 1 |
| Engemann, R | 1 |
| Thiede, A | 1 |
| Hassall, E | 1 |
| Muñoz, N | 1 |
| Vivas, J | 1 |
| Buiatti, E | 1 |
| Kato, I | 1 |
| Oliver, W | 1 |
| Uemura, N | 1 |
| Mukai, T | 1 |
| Okamoto, S | 1 |
| Yamaguchi, S | 1 |
| Mashiba, H | 1 |
| Taniyama, K | 1 |
| Sasaki, N | 1 |
| Haruma, K | 1 |
| Sumii, K | 1 |
| Kajiyama, G | 1 |
| Groves, FD | 1 |
| Heinrich, JP | 1 |
| Hu, J | 1 |
| Mark, SD | 1 |
| Rabkin, CS | 1 |
| Gossner, L | 1 |
| May, A | 1 |
| Seitz, G | 1 |
| Hahn, EG | 1 |
| Ell, C | 1 |
| Gotoda, T | 1 |
| Saito, D | 1 |
| Kondo, H | 1 |
| Ono, H | 1 |
| Oda, I | 1 |
| Fujishiro, M | 1 |
| Yamaguchi, H | 1 |
| Ofman, JJ | 1 |
| Lewin, K | 1 |
| Ramers, C | 1 |
| Ippoliti, A | 1 |
| Lieberman, D | 1 |
| Weinstein, W | 1 |
| Ohkusa, T | 1 |
| Fujiki, K | 1 |
| Takashimizu, I | 1 |
| Kumagai, J | 1 |
| Tanizawa, T | 1 |
| Eishi, Y | 1 |
| Yokoyama, T | 1 |
| Watanabe, M | 1 |
| Heinrich, J | 1 |
| Yang, CS | 1 |
| McDonald, JM | 1 |
| Longnecker, DS | 1 |
| Bell, RH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Hybrid and Bismuth Containing Quadruple Therapies for Helicobacter Pylori Eradication: a Randomized Controlled Trial[NCT02541864] | 330 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection - a Randomized Controlled Trial (REHYTRI Study)[NCT02359435] | 440 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| A Phase II, Multi-Center Study of Interventional Spray Cryotherapy for Early-Stage Esophageal Cancer (ICE-CANCER)[NCT01868139] | 1 participants (Actual) | Interventional | 2013-06-30 | Terminated (stopped due to insufficient accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Repeated endoscopy with rapid urease test, histological examination and culture or urea breath tests are conducted to assess H. pylori status. (NCT02541864)
Timeframe: at the 6th week after the end of anti- H. pylori therapy
| Intervention | participants (Number) |
|---|---|
| Pantoprazole+Bismuth+Tetra+Metro | 154 |
| Hybrid Therapy | 154 |
Evaluate eradication outcome by endoscopy urease test and histology or urea breath test (NCT02359435)
Timeframe: at the 6th week after the end of anti- H. pylori therapy
| Intervention | participants (Number) |
|---|---|
| Reverse Hybrid Therapy | 206 |
| Standard Triple Therapy | 191 |
4 reviews available for omeprazole and Precancerous Conditions
| Article | Year |
|---|---|
Does antireflux surgery prevent progression of Barrett's esophagus?
Topics: Adenocarcinoma; Barrett Esophagus; Cohort Studies; Combined Modality Therapy; Disease Progression; E | 2011 |
High-grade dysplasia in Barrett's oesophagus. The case against oesophageal resection.
Topics: Anti-Ulcer Agents; Barrett Esophagus; Endoscopy, Gastrointestinal; Esophageal Neoplasms; Esophagecto | 2007 |
[Surgical or conservative therapy of Barrett esophagus?].
Topics: Antacids; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Follow-Up Studies; Gastroesophageal Re | 1994 |
Barrett's esophagus: new definitions and approaches in children.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Child; Child, Preschool; Cimetidine; End | 1993 |
14 trials available for omeprazole and Precancerous Conditions
| Article | Year |
|---|---|
Addition of all-trans-retinoic acid to omeprazole and sucralfate therapy improves the prognosis of gastric dysplasia.
Topics: Adult; Aged; Double-Blind Method; Drug Therapy, Combination; Female; Gastric Mucosa; Humans; Intesti | 2015 |
Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Celecoxib; China; Clarithromycin; Cyclooxygenase 2; Cyclo | 2015 |
Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Celecoxib; Clarithromycin; Cyclooxygenase 2 Inhibitors; D | 2012 |
Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Ascorbic Acid; China; Confounding Factors, Epidemio | 2012 |
Eradication rate of Helicobacter pylori in a Mexican population at high risk for gastric cancer and use of serology to assess cure.
Topics: Adenocarcinoma; Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Antibodies, Bacterial; | 2002 |
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin | 2004 |
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin | 2004 |
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin | 2004 |
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin | 2004 |
Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication.
Topics: Aged; Amoxicillin; Anti-Ulcer Agents; Clarithromycin; Disease Progression; Drug Therapy, Combination | 2004 |
Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions.
Topics: Adult; Amoxicillin; Ascorbic Acid; China; Disease Progression; Double-Blind Method; Drug Therapy, Co | 2006 |
Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett's high-grade dysplasia.
Topics: Adenocarcinoma; Aged; Anti-Ulcer Agents; Barrett Esophagus; Biopsy; Combined Modality Therapy; Dihem | 2007 |
Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study design and baseline data.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anticarcinogenic Agents; Antioxidants; Clarithromyc | 1996 |
Factorial trial of three interventions to reduce the progression of precancerous gastric lesions in Shandong, China: design issues and initial data.
Topics: Adult; Amoxicillin; Anti-Ulcer Agents; Ascorbic Acid; China; Double-Blind Method; Drug Therapy, Comb | 1998 |
KTP laser destruction of dysplasia and early cancer in columnar-lined Barrett's esophagus.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Barrett Esophagus; Esophageal Neo | 1999 |
The economic impact of the diagnosis of dysplasia in Barrett's esophagus.
Topics: Anti-Ulcer Agents; Barrett Esophagus; Biopsy; Cost-Benefit Analysis; Esophageal Neoplasms; Esophagos | 2000 |
An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity.
Topics: Adult; Aged; Amoxicillin; Antioxidants; Ascorbic Acid; beta Carotene; China; Double-Blind Method; Dr | 2001 |
13 other studies available for omeprazole and Precancerous Conditions
| Article | Year |
|---|---|
Effects of Helicobacter pylori treatment on gastric cancer incidence and mortality in subgroups.
Topics: Adult; Age Factors; Aged; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Fol | 2014 |
Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model.
Topics: Animals; Anti-Bacterial Agents; Chemokine CXCL10; Chemokine CXCL9; Clarithromycin; Gastric Mucosa; G | 2015 |
Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Growth Processes; Colonic Neoplasms; | 2012 |
Ablative mucosectomy is the procedure of choice to prevent Barrett's cancer.
Topics: Adenocarcinoma; Anti-Ulcer Agents; Barrett Esophagus; Catheter Ablation; Esophageal Neoplasms; Esoph | 2003 |
[Patient with increased stomach cancer risk. Helicobacter can cause damage here].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Benzimidazoles; Clarithromycin; Drug Therapy, | 2002 |
Photodynamic therapy for Barrett's esophagus with dysplasia and/or early stage carcinoma: long-term results.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Barrett Esophagus; Esophageal Neo | 2003 |
Porfimer sodium photodynamic therapy for management of Barrett's esophagus with high-grade dysplasia.
Topics: Anti-Ulcer Agents; Barrett Esophagus; Catheter Ablation; Dihematoporphyrin Ether; Esophageal Neoplas | 2006 |
Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.
Topics: Animals; Anti-Infective Agents; Anti-Ulcer Agents; Carcinoma in Situ; Cell Proliferation; Clarithrom | 2008 |
Observation of gastric glandular cysts in the corpus mucosa of the stomach under omeprazole treatment.
Topics: Adult; Aged; Cysts; Diagnosis, Differential; Female; Gastric Mucosa; Gastroesophageal Reflux; Humans | 1995 |
Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Biopsy; Clarithromycin; Combined Modality Therapy; Dose | 1997 |
Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenoma; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; A | 1999 |
Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Biop | 2001 |
Effect of hypergastrinemia on pancreatic carcinogenesis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenoma; Animals; Anti-Ulcer Agents; Azaserine; Carcinoma i | 2002 |