Page last updated: 2024-11-01

omeprazole and Myocardial Infarction

omeprazole has been researched along with Myocardial Infarction in 20 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Research Excerpts

ExcerptRelevanceReference
"It remains unclear whether concomitant use of omeprazole attenuates platelet function as compared with that of famotidine in patients with acute coronary syndromes (ACS) who receive clopidogrel."9.16Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study. ( Endo, T; Fukui, K; Hibi, K; Himeno, H; Kimura, K; Morita, S; Sugano, T; Tsukahara, K; Umemura, S; Yano, H, 2012)
"In this randomized crossover study analyzing patients after acute myocardial infarction, omeprazole coadministration showed a significant pharmacodynamic interaction with clopidogrel, whereas pantoprazole did not."9.15Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction. ( Albuquerque, A; Araújo, C; Fontes-Carvalho, R; Pimentel-Nunes, P; Ribeiro, VG, 2011)
"We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue."7.91Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats. ( Goyal, SN; Mahajan, UB; Ojha, S; Patil, AS; Patil, CR; Singh, AD, 2019)
" It is unclear if polymyositis was triggered by interaction of the statin with omeprazole and/or gemfibrozil, or if it developed secondary to long-term use of atorvastatin only."5.39Statin-associated polymyositis following omeprazole treatment. ( Flores, RM; Kanth, R; Shah, MS, 2013)
"Among patients who had MINS, dabigatran 110 mg twice daily lowered the risk of major vascular complications, with no significant increase in major bleeding."5.27Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. ( Bangdiwala, SI; Berwanger, O; Biccard, BM; Botto, F; Chaudhry, NK; Connolly, SJ; de Nadal, M; Devereaux, PJ; Duceppe, E; Eikelboom, JW; Erb, J; Franzosi, MG; Guyatt, G; Hoeft, A; Iglesias, PP; Kearon, C; Magloire, P; Mayosi, B; Meyhoff, CS; Neary, J; Pettit, S; Rahate, PV; Rao, M; Rao-Melacini, P; Rodseth, R; Sessler, DI; Sharma, M; Srinathan, SK; Szczeklik, W; Tandon, V; Villar, JC; Vincent, J; Xavier, D; Yusuf, S, 2018)
"It remains unclear whether concomitant use of omeprazole attenuates platelet function as compared with that of famotidine in patients with acute coronary syndromes (ACS) who receive clopidogrel."5.16Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study. ( Endo, T; Fukui, K; Hibi, K; Himeno, H; Kimura, K; Morita, S; Sugano, T; Tsukahara, K; Umemura, S; Yano, H, 2012)
"In this randomized crossover study analyzing patients after acute myocardial infarction, omeprazole coadministration showed a significant pharmacodynamic interaction with clopidogrel, whereas pantoprazole did not."5.15Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction. ( Albuquerque, A; Araújo, C; Fontes-Carvalho, R; Pimentel-Nunes, P; Ribeiro, VG, 2011)
"We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue."3.91Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats. ( Goyal, SN; Mahajan, UB; Ojha, S; Patil, AS; Patil, CR; Singh, AD, 2019)
" The first compares primary coronary angioplasty with streptokinase in the treatment of acute myocardial infarction, in the second trial, lansoprazole is compared with omeprazole in the treatment of reflux oesophagitis."3.70Sample size calculation in economic evaluations. ( Al, MJ; Michel, BC; Rutten, FF; van Hout, BA, 1998)
"Randomized patients with available aspirin dosing information in COGENT (N = 3,752) were divided into "low-dose" (≤ 100 mg) and "high-dose" (>100 mg) aspirin groups."2.82Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M, 2016)
" It is unclear if polymyositis was triggered by interaction of the statin with omeprazole and/or gemfibrozil, or if it developed secondary to long-term use of atorvastatin only."1.39Statin-associated polymyositis following omeprazole treatment. ( Flores, RM; Kanth, R; Shah, MS, 2013)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's4 (20.00)29.6817
2010's14 (70.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Muthiah, MD1
Zheng, H1
Chew, NWS1
Xiao, J1
Lim, LG1
Tan, HC1
Lee, CH1
Low, AF1
Foo, LL1
Richards, AM1
Dan, YY1
Ho, KY1
Yip, JWL1
Chan, MY1
Duceppe, E2
Yusuf, S2
Tandon, V2
Rodseth, R2
Biccard, BM2
Xavier, D2
Szczeklik, W2
Meyhoff, CS2
Franzosi, MG2
Vincent, J2
Srinathan, SK2
Parlow, J1
Magloire, P2
Neary, J2
Rao, M2
Chaudhry, NK2
Mayosi, B2
de Nadal, M2
Popova, E1
Villar, JC2
Botto, F2
Berwanger, O2
Guyatt, G2
Eikelboom, JW2
Sessler, DI2
Kearon, C2
Pettit, S2
Connolly, SJ2
Sharma, M2
Bangdiwala, SI2
Devereaux, PJ2
Erb, J1
Rahate, PV1
Iglesias, PP1
Rao-Melacini, P1
Hoeft, A1
Patil, AS1
Singh, AD1
Mahajan, UB1
Patil, CR1
Ojha, S1
Goyal, SN1
Kanth, R1
Shah, MS1
Flores, RM1
Vaduganathan, M1
Bhatt, DL1
Cryer, BL1
Liu, Y1
Hsieh, WH1
Doros, G1
Cohen, M1
Lanas, A1
Schnitzer, TJ1
Shook, TL1
Lapuerta, P1
Goldsmith, MA1
Laine, L1
Cannon, CP1
Gao, QP1
Sun, Y1
Sun, YX1
Wang, LF1
Fu, L1
Friesen, MH1
Juhász, M1
Herszényi, L1
Tulassay, Z1
Zairis, MN1
Tsiaousis, GZ1
Patsourakos, NG1
Georgilas, AT1
Kontos, CF1
Adamopoulou, EN1
Vogiatzidis, K1
Argyrakis, SK1
Fakiolas, CN1
Foussas, SG1
Tran, M1
Tafreshi, J1
Pai, RG1
Fontes-Carvalho, R1
Albuquerque, A1
Araújo, C1
Pimentel-Nunes, P1
Ribeiro, VG1
Yano, H1
Tsukahara, K1
Morita, S1
Endo, T1
Sugano, T1
Hibi, K1
Himeno, H1
Fukui, K1
Umemura, S1
Kimura, K1
Simpson, SE1
Mahabaleshwarkar, RK1
Yang, Y1
Datar, MV1
Bentley, JP1
Strum, MW1
Banahan, BF1
Null, KD1
Yang, YX1
Lewis, JD1
Gilard, M1
Arnaud, B1
Cornily, JC1
Le Gal, G1
Lacut, K1
Le Calvez, G1
Mansourati, J1
Mottier, D1
Abgrall, JF1
Boschat, J1
Al, MJ1
van Hout, BA1
Michel, BC1
Rutten, FF1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Large, International, Randomized, Placebo-controlled Trial to Assess the Impact of Dabigatran (a Direct Thrombin Inhibitor) and Omeprazole (a Proton-pump Inhibitor) in Patients Suffering Myocardial Injury After Noncardiac Surgery[NCT01661101]Phase 31,754 participants (Actual)Interventional2013-01-31Completed
Epidemiological Patterns, Management Strategies and Cost Analysis of Care for the Patient With Perioperative Myocardial Injury When BNP is Used as a Screening Tool for Non-Cardiac Surgery[NCT04077294]333 participants (Actual)Observational2019-05-21Completed
"PGDT With the Hypotension Prediction Index to Reduce the Number and Duration of Intraoperative Hypotension and the Incidence of Renal Failure in Patients Undergoing Lung Surgery"[NCT04149314]142 participants (Actual)Interventional2019-11-20Completed
Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652]502 participants (Actual)Observational [Patient Registry]2015-01-01Completed
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease[NCT00557921]Phase 35,000 participants (Anticipated)Interventional2007-12-31Terminated (stopped due to Terminated by Sponsor)
Influence Of Omeprazole On The Anti-Platelet Action Of Clopidogrel Associated To Aspirin: Double-Blind Randomized Trial Against Placebo[NCT00349661]Phase 3120 participants (Anticipated)Interventional2006-06-30Completed
Clopidogrel and Proton Pump Inhibitors: A Propensity Score Adjusted Cohort Study to Examine a Possible Interaction: A CALIBER Study[NCT01231867]24,471 participants (Actual)Observational2010-12-31Completed
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]228 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Healed Peptic Ulcer

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Interventionparticipants (Number)
Histamine-2 Receptor Antagonist Group106
Placebo Group101

Reviews

4 reviews available for omeprazole and Myocardial Infarction

ArticleYear
Outcomes of a multi-ethnic Asian population on combined treatment with clopidogrel and omeprazole in 12,440 patients.
    Journal of thrombosis and thrombolysis, 2021, Volume: 52, Issue:3

    Topics: Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Ethnicity; Humans; Myocardia

2021
Current standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist.
    Digestion, 2010, Volume: 81, Issue:1

    Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Interactions; Dr

2010
Review article: combination of clopidogrel and proton pump inhibitors: implications for clinicians.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Cytoc

2010
Prevention and treatment of stress ulcers in critically ill patients.
    Seminars in gastrointestinal disease, 2003, Volume: 14, Issue:1

    Topics: Aged; Anti-Ulcer Agents; Cimetidine; Critical Illness; Female; Gastric Mucosa; Gastrointestinal Hemo

2003

Trials

7 trials available for omeprazole and Myocardial Infarction

ArticleYear
Design of a Randomized Placebo-Controlled Trial to Assess Dabigatran and Omeprazole in Patients with Myocardial Injury after Noncardiac Surgery (MANAGE).
    The Canadian journal of cardiology, 2018, Volume: 34, Issue:3

    Topics: Aged; Cause of Death; Dabigatran; Double-Blind Method; Female; Follow-Up Studies; Humans; Internatio

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
    Lancet (London, England), 2018, 06-09, Volume: 391, Issue:10137

    Topics: Aged; Aged, 80 and over; Antithrombins; Dabigatran; Female; Hemorrhage; Humans; Male; Myocardial Inf

2018
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.
    Journal of the American College of Cardiology, 2016, Apr-12, Volume: 67, Issue:14

    Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia;

2016
Early use of omeprazole benefits patients with acute myocardial infarction.
    Journal of thrombosis and thrombolysis, 2009, Volume: 28, Issue:3

    Topics: Adult; Anti-Ulcer Agents; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Humans; Incidenc

2009
Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction.
    European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Cross-Over Studies; Dru

2011
Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:11

    Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Drug Antago

2012
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
    Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Dru

2008

Other Studies

9 other studies available for omeprazole and Myocardial Infarction

ArticleYear
Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats.
    Molecular and cellular biochemistry, 2019, Volume: 456, Issue:1-2

    Topics: Animals; Electrocardiography; Lansoprazole; Male; Malondialdehyde; Myocardial Infarction; Myocardium

2019
Statin-associated polymyositis following omeprazole treatment.
    Clinical medicine & research, 2013, Volume: 11, Issue:2

    Topics: Anticholesteremic Agents; Atorvastatin; Drug Interactions; Esophagitis; Gemfibrozil; Heptanoic Acids

2013
Interaction between clopidogrel and proton pump inhibitors.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Jun-09, Volume: 180, Issue:12

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Case-Control Studies; Clopidogrel; Drug Interactions; Drug

2009
The impact of treatment with omeprazole on the effectiveness of clopidogrel drug therapy during the first year after successful coronary stenting.
    The Canadian journal of cardiology, 2010, Volume: 26, Issue:2

    Topics: Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel;

2010
If I take the blood thinner Plavix, should I avoid using Prilosec or other heartburn medications?
    Mayo Clinic women's healthsource, 2010, Volume: 14, Issue:5

    Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Health Knowledge, Atti

2010
I've taken aspirin for years to prevent heart attack, and now I've developed an ulcer. My doctor told me to keep taking aspirin along with Prilosec. Why keep taking aspirin if it caused my ulcer?
    Mayo Clinic health letter (English ed.), 2012, Volume: 30, Issue:3

    Topics: Anti-Ulcer Agents; Aspirin; Humans; Myocardial Infarction; Omeprazole; Peptic Ulcer; Platelet Aggreg

2012
A positive event dependence model for self-controlled case series with applications in postmarketing surveillance.
    Biometrics, 2013, Volume: 69, Issue:1

    Topics: Computer Simulation; Esomeprazole; Humans; Lactones; Models, Statistical; Myocardial Infarction; Ome

2013
Risk of adverse cardiovascular outcomes and all-cause mortality associated with concomitant use of clopidogrel and proton pump inhibitors in elderly patients.
    Current medical research and opinion, 2013, Volume: 29, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel;

2013
Sample size calculation in economic evaluations.
    Health economics, 1998, Volume: 7, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Angioplasty, Balloon, Coronary; Anti-Ulcer Agents; Cost-Ben

1998