omeprazole has been researched along with Melena in 7 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Melena: The black, tarry, foul-smelling FECES that contain degraded blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diarrhea was common (8/20 omeprazole, 5/17 placebo), hematochezia was rare (1/20 omeprazole, 1/17 placebo); melena was not observed." | 3.30 | Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion. ( Guadiano, P; Lewis, MJ; Mehra, JM; Moore, GE; Steiner, JM; Tolbert, MK, 2023) |
| "A patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel." | 1.31 | Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. ( Meijer, K; Peters, FT; van der Meer, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Mehra, JM | 1 |
| Tolbert, MK | 1 |
| Guadiano, P | 1 |
| Steiner, JM | 1 |
| Moore, GE | 1 |
| Lewis, MJ | 1 |
| Hrabovský, V | 1 |
| Mendlová, A | 1 |
| Zadák, Z | 1 |
| Bláha, V | 1 |
| Hyšpler, R | 1 |
| Tichá, A | 1 |
| Svagera, Z | 1 |
| Sancar, M | 1 |
| Izzettin, FV | 1 |
| Apikoglu-Rabus, S | 1 |
| Besisik, F | 1 |
| Tozun, N | 1 |
| Dulger, G | 1 |
| Meijer, K | 1 |
| Peters, FT | 1 |
| van der Meer, J | 1 |
| Langman, MJ | 2 |
| Daneshmend, TK | 1 |
| Hawkey, CJ | 1 |
| Logan, RF | 1 |
| Long, RG | 1 |
| Walt, RP | 1 |
| Lee, ML | 1 |
| Piper, DW | 1 |
| Fischer, GO | 1 |
| De Launey, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Using Preendoscopic Proton Pump Inhibitors in Upper Gastrointestinal System Bleeding on Patient Prognosis[NCT05467358] | 1,100 participants (Actual) | Observational | 2021-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for omeprazole and Melena
| Article | Year |
|---|---|
Testing the efficacy of antisecretory drugs in patients with haematemesis and melaena.
Topics: Hematemesis; Histamine H2 Antagonists; Humans; Melena; Meta-Analysis as Topic; Omeprazole; Randomize | 1991 |
3 trials available for omeprazole and Melena
| Article | Year |
|---|---|
Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion.
Topics: Animals; Diarrhea; Dog Diseases; Dogs; Gastrointestinal Hemorrhage; Intervertebral Disc; Interverteb | 2023 |
Pharmacoeconomic comparison of Helicobacter pylori eradication regimens.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Amoxicillin; Anti-Infective Agents; Clar | 2006 |
Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial.
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Endoscopy, Gastrointestin | 1992 |
3 other studies available for omeprazole and Melena
| Article | Year |
|---|---|
Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations.
Topics: Acute Disease; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Combined Modal | 2012 |
Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa.
Topics: Angiodysplasia; Blood Transfusion; Combined Modality Therapy; Deamino Arginine Vasopressin; Estrogen | 2001 |
Lichen spinulosus after the ingestion of omeprazole.
Topics: Adult; Female; Humans; Melena; Omeprazole; Skin Diseases | 1989 |