Page last updated: 2024-11-01

omeprazole and Melena

omeprazole has been researched along with Melena in 7 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Melena: The black, tarry, foul-smelling FECES that contain degraded blood.

Research Excerpts

ExcerptRelevanceReference
"Diarrhea was common (8/20 omeprazole, 5/17 placebo), hematochezia was rare (1/20 omeprazole, 1/17 placebo); melena was not observed."3.30Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion. ( Guadiano, P; Lewis, MJ; Mehra, JM; Moore, GE; Steiner, JM; Tolbert, MK, 2023)
"A patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel."1.31Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. ( Meijer, K; Peters, FT; van der Meer, J, 2001)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Mehra, JM1
Tolbert, MK1
Guadiano, P1
Steiner, JM1
Moore, GE1
Lewis, MJ1
Hrabovský, V1
Mendlová, A1
Zadák, Z1
Bláha, V1
Hyšpler, R1
Tichá, A1
Svagera, Z1
Sancar, M1
Izzettin, FV1
Apikoglu-Rabus, S1
Besisik, F1
Tozun, N1
Dulger, G1
Meijer, K1
Peters, FT1
van der Meer, J1
Langman, MJ2
Daneshmend, TK1
Hawkey, CJ1
Logan, RF1
Long, RG1
Walt, RP1
Lee, ML1
Piper, DW1
Fischer, GO1
De Launey, WE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Using Preendoscopic Proton Pump Inhibitors in Upper Gastrointestinal System Bleeding on Patient Prognosis[NCT05467358]1,100 participants (Actual)Observational2021-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for omeprazole and Melena

ArticleYear
Testing the efficacy of antisecretory drugs in patients with haematemesis and melaena.
    Gastroenterologia Japonica, 1991, Volume: 26 Suppl 3

    Topics: Hematemesis; Histamine H2 Antagonists; Humans; Melena; Meta-Analysis as Topic; Omeprazole; Randomize

1991

Trials

3 trials available for omeprazole and Melena

ArticleYear
Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion.
    Journal of veterinary internal medicine, 2023, Volume: 37, Issue:2

    Topics: Animals; Diarrhea; Dog Diseases; Dogs; Gastrointestinal Hemorrhage; Intervertebral Disc; Interverteb

2023
Pharmacoeconomic comparison of Helicobacter pylori eradication regimens.
    Pharmacy world & science : PWS, 2006, Volume: 28, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Amoxicillin; Anti-Infective Agents; Clar

2006
Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial.
    BMJ (Clinical research ed.), 1992, Jan-18, Volume: 304, Issue:6820

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Endoscopy, Gastrointestin

1992

Other Studies

3 other studies available for omeprazole and Melena

ArticleYear
Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations.
    Wiener klinische Wochenschrift, 2012, Volume: 124, Issue:23-24

    Topics: Acute Disease; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Combined Modal

2012
Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2001, Volume: 12, Issue:3

    Topics: Angiodysplasia; Blood Transfusion; Combined Modality Therapy; Deamino Arginine Vasopressin; Estrogen

2001
Lichen spinulosus after the ingestion of omeprazole.
    The Medical journal of Australia, 1989, Apr-03, Volume: 150, Issue:7

    Topics: Adult; Female; Humans; Melena; Omeprazole; Skin Diseases

1989