omeprazole and Leukemia
omeprazole has been researched along with Leukemia in 3 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple modes of light-induced biological activities due to production of singlet oxygen and/or excited-state proton transfer with consequent pH drop in the hypericin environment." | 5.31 | Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. ( Mirossay, A; Mirossay, L; Mojzis, J; Papp, P; Sarisský, M, 2002) |
| "Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple modes of light-induced biological activities due to production of singlet oxygen and/or excited-state proton transfer with consequent pH drop in the hypericin environment." | 1.31 | Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. ( Mirossay, A; Mirossay, L; Mojzis, J; Papp, P; Sarisský, M, 2002) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, WL | 1 |
| Li, DD | 1 |
| Chen, X | 1 |
| Wang, YZ | 1 |
| Xu, JJ | 1 |
| Jiang, ZY | 1 |
| You, QD | 1 |
| Guo, XK | 1 |
| Mirossay, A | 2 |
| Mirossay, L | 2 |
| Sarisský, M | 1 |
| Papp, P | 1 |
| Mojzis, J | 2 |
| Kocisová, E | 1 |
| Radváková, I | 1 |
| Miskovský, P | 1 |
Other Studies
3 other studies available for omeprazole and Leukemia
| Article | Year |
|---|---|
Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2020 |
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
Topics: Amiloride; Anthracenes; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; | 2002 |
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger.
Topics: Amiloride; Anthracenes; Antineoplastic Agents; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Human | 1999 |