Page last updated: 2024-11-01

omeprazole and Leukemia

omeprazole has been researched along with Leukemia in 3 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple modes of light-induced biological activities due to production of singlet oxygen and/or excited-state proton transfer with consequent pH drop in the hypericin environment."5.31Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. ( Mirossay, A; Mirossay, L; Mojzis, J; Papp, P; Sarisský, M, 2002)
"Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple modes of light-induced biological activities due to production of singlet oxygen and/or excited-state proton transfer with consequent pH drop in the hypericin environment."1.31Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole. ( Mirossay, A; Mirossay, L; Mojzis, J; Papp, P; Sarisský, M, 2002)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Chen, WL1
Li, DD1
Chen, X1
Wang, YZ1
Xu, JJ1
Jiang, ZY1
You, QD1
Guo, XK1
Mirossay, A2
Mirossay, L2
Sarisský, M1
Papp, P1
Mojzis, J2
Kocisová, E1
Radváková, I1
Miskovský, P1

Other Studies

3 other studies available for omeprazole and Leukemia

ArticleYear
Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
    European journal of medicinal chemistry, 2020, Feb-15, Volume: 188

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug

2020
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
    Physiological research, 2002, Volume: 51, Issue:6

    Topics: Amiloride; Anthracenes; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions;

2002
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger.
    Physiological research, 1999, Volume: 48, Issue:2

    Topics: Amiloride; Anthracenes; Antineoplastic Agents; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Human

1999