omeprazole has been researched along with Intestinal Perforation in 5 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Intestinal Perforation: Opening or penetration through the wall of the INTESTINES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Randomized patients with available aspirin dosing information in COGENT (N = 3,752) were divided into "low-dose" (≤ 100 mg) and "high-dose" (>100 mg) aspirin groups." | 2.82 | Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M, 2016) |
| "Calcium gluconate was injected directly into the arteries supplying the pancreas and liver after standard selective angiography." | 1.33 | Localization of gastrinomas by selective intra-arterial calcium injection in patients on proton pump inhibitor or H2 receptor antagonist therapy. ( Bloom, SR; Dhillo, WS; Jackson, JE; Jayasena, CN; Lynn, JA; Meeran, K; Todd, JF, 2005) |
| "Exploration found volvulus and a gangrenous segment of the distal ileum." | 1.32 | Massive gastrointestinal bleeding in infants with ascariasis. ( Chedphaopan, J; Mitamun, W; Patrapinyokul, S; Sangkhathat, S; Wudhisuthimethawee, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-Romera, Á | 1 |
| Soto-Darias, I | 1 |
| González-Hernández, S | 1 |
| González-Delgado, C | 1 |
| Bravo-Gutiérrez, A | 1 |
| Vaduganathan, M | 1 |
| Bhatt, DL | 1 |
| Cryer, BL | 1 |
| Liu, Y | 1 |
| Hsieh, WH | 1 |
| Doros, G | 1 |
| Cohen, M | 1 |
| Lanas, A | 1 |
| Schnitzer, TJ | 1 |
| Shook, TL | 1 |
| Lapuerta, P | 1 |
| Goldsmith, MA | 1 |
| Laine, L | 1 |
| Cannon, CP | 1 |
| Sangkhathat, S | 1 |
| Patrapinyokul, S | 1 |
| Wudhisuthimethawee, P | 1 |
| Chedphaopan, J | 1 |
| Mitamun, W | 1 |
| Dhillo, WS | 1 |
| Jayasena, CN | 1 |
| Jackson, JE | 1 |
| Lynn, JA | 1 |
| Bloom, SR | 1 |
| Meeran, K | 1 |
| Todd, JF | 1 |
| Hirschowitz, BI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease[NCT00557921] | Phase 3 | 5,000 participants (Anticipated) | Interventional | 2007-12-31 | Terminated (stopped due to Terminated by Sponsor) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for omeprazole and Intestinal Perforation
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Digestive System; Gastrointestinal H | 1994 |
1 trial available for omeprazole and Intestinal Perforation
| Article | Year |
|---|---|
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia; | 2016 |
3 other studies available for omeprazole and Intestinal Perforation
| Article | Year |
|---|---|
Small bowel obstruction secondary to enteroenteric fistula: An uncommon complication in chronic NSAID users.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Female; Huma | 2020 |
Massive gastrointestinal bleeding in infants with ascariasis.
Topics: Animals; Anthelmintics; Ascariasis; Ascaris lumbricoides; Blood Transfusion; Child, Preschool; Combi | 2003 |
Localization of gastrinomas by selective intra-arterial calcium injection in patients on proton pump inhibitor or H2 receptor antagonist therapy.
Topics: Adult; Blood Specimen Collection; Calcium Gluconate; Female; Gastrinoma; Hepatic Veins; Histamine H2 | 2005 |