Compounds > omeprazole
Page last updated: 2024-11-01

omeprazole and Interstitial Nephritis

omeprazole has been researched along with Interstitial Nephritis in 41 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Research Excerpts

ExcerptRelevanceReference
" Omeprazole is a drug widely used in the treatment of gastroesophageal reflux disease and peptic ulcer disease."8.82[Acute interstitial nephritis associated with omeprazole therapy]. ( Calvo, C; García, H; Hernández-Jaras, J; Maduell, F; Rovira, RE; Torregrosa, E, 2004)
"Acute renal impairment secondary to interstitial nephritis is a rare complication of omeprazole."8.79Omeprazole-induced interstitial nephritis. ( Findlay, M; Horvath, J; Jardine, M; Kovac, S; Yip, D, 1997)
"Omeprazole is an important cause of drug-induced acute interstitial nephritis (AIN)."7.80Omeprazole-induced acute interstitial nephritis: a possible Th1-Th17-mediated injury? ( Berney-Meyer, L; Hung, N; Kitching, AR; Schollum, JB; Slatter, T; Walker, RJ, 2014)
"Omeprazole-induced acute interstitial nephritis (OIAIN) is a rare adverse event."7.76Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype. ( de Zoysa, JR; Helsby, NA; Lo, WY; Logan, KE; Schollum, JB; Searle, M; Simpson, IJ; Voss, DM, 2010)
" The patient had initiated treatment with oral pantoprazole 40 mg/d for gastroesophageal reflux 2 months prior to admission."7.72Acute interstitial nephritis due to pantoprazole. ( Ra, A; Tobe, SW, 2004)
"Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders."6.41Acute interstitial nephritis due to omeprazole. ( Hollomby, DJ; McLaughlin, K; Myers, RP, 2001)
"Drug-induced interstitial nephritis is a common cause of acute kidney injury indicated by elevated serum creatinine."5.40Granulomatous tubulointerstitial nephritis secondary to omeprazole. ( Althaf, MM; Nadri, Q, 2014)
"Acute interstitial nephritis is an uncommon but important cause of acute renal failure."5.33Rabeprazole-induced acute interstitial nephritis. ( Coleman, PL; Geevasinga, N; Roger, SD, 2005)
"Omeprazole is a proton pump inhibitor widely used for the treatment of peptic ulcer disease."5.30Omeprazole-induced acute interstitial nephritis. ( d'Adamo, G; Forte, F; Gangeri, F; Spinelli, C, 1997)
" Omeprazole is a drug widely used in the treatment of gastroesophageal reflux disease and peptic ulcer disease."4.82[Acute interstitial nephritis associated with omeprazole therapy]. ( Calvo, C; García, H; Hernández-Jaras, J; Maduell, F; Rovira, RE; Torregrosa, E, 2004)
"Acute renal impairment secondary to interstitial nephritis is a rare complication of omeprazole."4.79Omeprazole-induced interstitial nephritis. ( Findlay, M; Horvath, J; Jardine, M; Kovac, S; Yip, D, 1997)
"Omeprazole is an important cause of drug-induced acute interstitial nephritis (AIN)."3.80Omeprazole-induced acute interstitial nephritis: a possible Th1-Th17-mediated injury? ( Berney-Meyer, L; Hung, N; Kitching, AR; Schollum, JB; Slatter, T; Walker, RJ, 2014)
"Three patients were diagnosed with drug-induced tubulointerstitial nephritis: a 72-year-old woman who was using a proton pump inhibitor, an 83-year-old woman who had recently been treated with antibiotics and an 83-year-old man who was using omeprazole."3.77[Drug-induced tubulointerstitial nephritis]. ( de Waal, YR; Dofferhoff, AS; Ixkes, MC; Steenbergen, E, 2011)
"Omeprazole-induced acute interstitial nephritis (OIAIN) is a rare adverse event."3.76Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype. ( de Zoysa, JR; Helsby, NA; Lo, WY; Logan, KE; Schollum, JB; Searle, M; Simpson, IJ; Voss, DM, 2010)
" The patient had initiated treatment with oral pantoprazole 40 mg/d for gastroesophageal reflux 2 months prior to admission."3.72Acute interstitial nephritis due to pantoprazole. ( Ra, A; Tobe, SW, 2004)
"Omeprazole is a proton pump inhibitor widely used in the treatment of gastro-esophageal reflux disease and peptic ulcer disease."3.70Reversible renal failure after treatment with omeprazole. ( Post, AT; Voorhorst, G; Zanen, AL, 2000)
"Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders."2.41Acute interstitial nephritis due to omeprazole. ( Hollomby, DJ; McLaughlin, K; Myers, RP, 2001)
"Drug-induced interstitial nephritis is a common cause of acute kidney injury indicated by elevated serum creatinine."1.40Granulomatous tubulointerstitial nephritis secondary to omeprazole. ( Althaf, MM; Nadri, Q, 2014)
"Acute interstitial nephritis is an uncommon but important cause of acute renal failure."1.33Rabeprazole-induced acute interstitial nephritis. ( Coleman, PL; Geevasinga, N; Roger, SD, 2005)
"Omeprazole is a proton pump inhibitor widely used for the treatment of peptic ulcer disease."1.30Omeprazole-induced acute interstitial nephritis. ( d'Adamo, G; Forte, F; Gangeri, F; Spinelli, C, 1997)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (34.15)18.2507
2000's18 (43.90)29.6817
2010's9 (21.95)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berney-Meyer, L1
Hung, N1
Slatter, T1
Schollum, JB2
Kitching, AR1
Walker, RJ1
Nadri, Q1
Althaf, MM1
Torlot, FJ1
Whitehead, DJ1
Krishnamurthy, M1
Snyder, R1
Bachurina, M1
Helsby, NA1
Lo, WY1
Simpson, IJ2
Voss, DM1
Logan, KE1
Searle, M1
de Zoysa, JR1
Ray, S1
Delaney, M1
Muller, AF1
Schaffer, AC1
Grad, Y1
Ross, JJ1
Grad, YH1
Seifter, JL1
Levy, BD1
Loscalzo, J1
Ni, N1
Moeckel, GW1
Kumar, C1
de Waal, YR1
Ixkes, MC1
Steenbergen, E1
Dofferhoff, AS1
Delve, P1
Lau, M1
Yun, K1
Walker, R1
Ra, A1
Tobe, SW1
Torpey, N1
Barker, T1
Ross, C1
Torregrosa, E1
Rovira, RE1
Calvo, C1
Hernández-Jaras, J1
Maduell, F1
García, H1
Geevasinga, N2
Coleman, PL2
Roger, SD3
García García, M1
Illaro Uranga, A1
Aguirre Gómez, C1
Saracho Rotaeche, R1
Ruiz Osante, B1
Jacobs-Kosmin, D1
Derk, CT1
Sandorfi, N1
Webster, AC1
Marshall, MR1
Pilmore, H1
Manley, P1
Williams, L1
Thein, H1
Voss, D1
Babb, RR1
Brewster, UC1
Perazella, MA1
Assouad, M1
Vicks, SL1
Pokroy, MV1
Willcourt, RJ1
Singer, S1
Parry, RG1
Deodhar, HA1
Barnes, JN1
Lewis, CR1
Somerville, C1
Agar, JW1
Jones, B1
Hewson, E1
Price, A1
Kuiper, JJ1
Fleury, D1
Storkebaum, H1
Mougenot, B1
Bridoux, F1
Gobert, P1
Lemaitre, V1
Vanhille, P1
d'Adamo, G1
Spinelli, C1
Forte, F1
Gangeri, F1
Badov, D1
Perry, G1
Lambert, J1
Dowling, J1
Yip, D1
Kovac, S1
Jardine, M1
Horvath, J1
Findlay, M1
Montseny, JJ1
Meyrier, A1
Segarra Soria, MA1
Teruel López, CJ1
Calvo Gordo, C1
Lázaro Santander, R1
Usó Blasco, J1
Jacobson, SH1
Sundelin, B1
Geetha, D1
Post, AT1
Voorhorst, G1
Zanen, AL1
Wall, CA1
Gaffney, EF1
Mellotte, GJ1
Shuster, J1
Myers, RP1
McLaughlin, K1
Hollomby, DJ1
Vera Rivera, M1
Pou Potau, M1
Botey Puig, A1
Ruffenach, SJ1
Siskind, MS1
Lien, YH1

Reviews

4 reviews available for omeprazole and Interstitial Nephritis

ArticleYear
[Acute interstitial nephritis associated with omeprazole therapy].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24 Suppl 3

    Topics: Acute Disease; Aged; Combined Modality Therapy; Enzyme Inhibitors; Female; Gastroesophageal Reflux;

2004
Omeprazole-induced interstitial nephritis.
    Journal of clinical gastroenterology, 1997, Volume: 25, Issue:2

    Topics: Anti-Ulcer Agents; Female; Humans; Middle Aged; Nephritis, Interstitial; Omeprazole

1997
Immunoallergic granulomatous interstitial nephritis following treatment with omeprazole.
    American journal of nephrology, 1998, Volume: 18, Issue:3

    Topics: Aged; Anti-Ulcer Agents; Autoimmune Diseases; Humans; Kidney; Male; Myasthenia Gravis; Nephritis, In

1998
Acute interstitial nephritis due to omeprazole.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:12

    Topics: Acute Disease; Adult; Female; Humans; Kidney; Nephritis, Interstitial; Omeprazole; Proton Pump Inhib

2001

Other Studies

37 other studies available for omeprazole and Interstitial Nephritis

ArticleYear
Omeprazole-induced acute interstitial nephritis: a possible Th1-Th17-mediated injury?
    Nephrology (Carlton, Vic.), 2014, Volume: 19, Issue:6

    Topics: Acute Disease; Aged; Aged, 80 and over; Biopsy; Eosinophils; Female; Humans; Immunophenotyping; Male

2014
Granulomatous tubulointerstitial nephritis secondary to omeprazole.
    BMJ case reports, 2014, Oct-16, Volume: 2014

    Topics: Acute Kidney Injury; Anti-Inflammatory Agents; Diagnosis, Differential; Female; Humans; Middle Aged;

2014
Acute interstitial nephritis caused by two different proton pump inhibitors.
    British journal of hospital medicine (London, England : 2005), 2016, Volume: 77, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Female; Humans; Middle Aged; Nephritis, Interstitial; Omepr

2016
Long-term use of proton pump inhibitors: are they really safe? A case of delayed acute interstitial nephritis.
    Journal of the American Geriatrics Society, 2009, Volume: 57, Issue:8

    Topics: Aged; Anti-Ulcer Agents; Gastroesophageal Reflux; Humans; Male; Nephritis, Interstitial; Omeprazole

2009
Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.
    British journal of clinical pharmacology, 2010, Volume: 69, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 C

2010
Proton pump inhibitors and acute interstitial nephritis.
    BMJ (Clinical research ed.), 2010, Sep-22, Volume: 341

    Topics: Acute Disease; Aged; Female; Humans; Middle Aged; Nephritis, Interstitial; Omeprazole; Proton Pump I

2010
Interactive medical case. Bitter pills.
    The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy; Creatini

2010
Clinical problem-solving. Bitter pills.
    The New England journal of medicine, 2010, Nov-04, Volume: 363, Issue:19

    Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Diagnosis, Di

2010
Late-onset omeprazole-associated acute interstitial nephritis.
    Journal of the American Geriatrics Society, 2010, Volume: 58, Issue:12

    Topics: Acute Disease; Aged; Anti-Ulcer Agents; Biopsy; Female; Humans; Nephritis, Interstitial; Omeprazole;

2010
[Drug-induced tubulointerstitial nephritis].
    Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:49

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Male; Nephritis, Interstitial; Omepr

2011
Omeprazole-induced acute interstitial nephritis.
    The New Zealand medical journal, 2003, Feb-21, Volume: 116, Issue:1169

    Topics: Aged; Female; Gastroesophageal Reflux; Humans; Nephritis, Interstitial; Omeprazole

2003
Acute interstitial nephritis due to pantoprazole.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Administration, Oral; Aged; Benzimidazoles;

2004
Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Creatinine; Enzyme Inhibitors; Fem

2004
Rabeprazole-induced acute interstitial nephritis.
    Nephrology (Carlton, Vic.), 2005, Volume: 10, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Acute Kidney Injury; Anti-Ulcer Agents; Benz

2005
[Omeprazol-associated intersticial nephritis. A case report].
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2005, Volume: 29, Issue:2

    Topics: Aged; Anti-Ulcer Agents; Female; Humans; Nephritis, Interstitial; Omeprazole; Treatment Outcome

2005
Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis.
    The Journal of rheumatology, 2006, Volume: 33, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Aged; Anti-Ulcer Agents; Antibodies, Antineu

2006
Proton pump inhibitors and acute interstitial nephritis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Kidney Injury; Adult; Age Distribution; Aged; Aged, 8

2006
Proton pump inhibitors: indigestion for nephrologists!
    Nephrology (Carlton, Vic.), 2006, Volume: 11, Issue:5

    Topics: Acute Kidney Injury; Enzyme Inhibitors; Humans; Nephritis, Interstitial; Nephrology; Omeprazole; Pro

2006
Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases.
    Nephrology (Carlton, Vic.), 2006, Volume: 11, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Kidney Injury; Aged; Aged, 80 and over; Anti-Ulcer Ag

2006
Proton pump inhibitors.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:10

    Topics: Enzyme Inhibitors; Gastroesophageal Reflux; Humans; Nephritis, Interstitial; Omeprazole; Proton Pump

2006
Acute kidney injury following proton pump inhibitor therapy.
    Kidney international, 2007, Volume: 71, Issue:6

    Topics: Anti-Ulcer Agents; Biopsy; Gastrointestinal Diseases; Humans; Kidney Glomerulus; Male; Middle Aged;

2007
Recurrent acute interstitial nephritis on rechallenge with omeprazole.
    Lancet (London, England), 1994, Aug-20, Volume: 344, Issue:8921

    Topics: Acute Disease; Aged; Humans; Male; Nephritis, Interstitial; Omeprazole; Recurrence

1994
Acute interstitial nephritis, omeprazole and antineutrophil cytoplasmic antibodies.
    Clinical nephrology, 1994, Volume: 42, Issue:4

    Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Biomarkers; Humans; Male; Nephritis, I

1994
Omeprazole induced acute interstitial nephritis.
    Australian and New Zealand journal of medicine, 1994, Volume: 24, Issue:5

    Topics: Acute Disease; Aged; Female; Humans; Nephritis, Interstitial; Omeprazole

1994
Acute interstitial nephritis due to omeprazole.
    Lancet (London, England), 1994, Oct-08, Volume: 344, Issue:8928

    Topics: Acute Disease; Aged; Female; Humans; Nephritis, Interstitial; Omeprazole

1994
Omeprazole-induced acute interstitial nephritis.
    The American journal of medicine, 1993, Volume: 95, Issue:2

    Topics: Acute Disease; Female; Humans; Middle Aged; Nephritis, Interstitial; Omeprazole

1993
Acute interstitial nephritis due to omeprazole.
    Clinical nephrology, 1995, Volume: 44, Issue:2

    Topics: Acute Disease; Aged; Enzyme Inhibitors; Humans; Male; Nephritis, Interstitial; Omeprazole

1995
Omeprazole-induced acute interstitial nephritis.
    Renal failure, 1997, Volume: 19, Issue:1

    Topics: Acute Disease; Aged; Anti-Ulcer Agents; Biopsy; Blood Urea Nitrogen; Creatinine; Duodenal Ulcer; Fem

1997
Acute interstitial nephritis secondary to omeprazole.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:11

    Topics: Acute Disease; Aged; Anti-Ulcer Agents; Female; Humans; Male; Nephritis, Interstitial; Omeprazole

1997
[Interstitial nephritis caused by omeprazole].
    Anales de medicina interna (Madrid, Spain : 1984), 1998, Volume: 15, Issue:11

    Topics: Anti-Ulcer Agents; Enzyme Inhibitors; Female; Humans; Middle Aged; Nephritis, Interstitial; Omeprazo

1998
[Losec was probably the cause of interstitial nephritis].
    Lakartidningen, 1999, Apr-07, Volume: 96, Issue:14

    Topics: Anti-Ulcer Agents; Biopsy; Humans; Kidney; Male; Middle Aged; Nephritis, Interstitial; Omeprazole

1999
Omeprazole-induced acute interstitial nephritis.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:11

    Topics: Acute Disease; Acute Kidney Injury; Aged; Anti-Ulcer Agents; Blood Urea Nitrogen; Creatinine; Diagno

1999
Reversible renal failure after treatment with omeprazole.
    The Netherlands journal of medicine, 2000, Volume: 57, Issue:2

    Topics: Acute Kidney Injury; Aged; Enzyme Inhibitors; Gastroesophageal Reflux; Humans; Male; Nephritis, Inte

2000
Hypercalcaemia and acute interstitial nephritis associated with omeprazole therapy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:9

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Female; Humans; Hypercalcemia; Nephritis, Interstiti

2000
Omeprazole and nephritis.
    Nursing, 2000, Volume: 30, Issue:10

    Topics: Acute Kidney Injury; Aged; Anti-Ulcer Agents; Dyspepsia; Female; Humans; Nephritis, Interstitial; Om

2000
[Omeprazole-induced interstitial nephritis: a reversible cause of acute renal failure].
    Medicina clinica, 2002, Jan-19, Volume: 118, Issue:1

    Topics: Acute Kidney Injury; Aged; Anti-Ulcer Agents; Humans; Male; Nephritis, Interstitial; Omeprazole

2002
Acute interstitial nephritis due to omeprazole.
    The American journal of medicine, 1992, Volume: 93, Issue:4

    Topics: Acute Disease; Aged; Esophagitis, Peptic; Female; Humans; Nephritis, Interstitial; Omeprazole

1992