omeprazole has been researched along with Hypertrophy in 15 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to investigate whether not only omeprazole but also lansoprazole leads to hypertrophy of the parietal cells of the gastric mucosa." | 9.09 | Treatment with lansoprazole also induces hypertrophy of the parietal cells of the stomach. ( Alexandridis, T; Meining, A; Seifert, E; Stolte, M, 2000) |
| "Paraffin-embedded and haematoxylin-eosin-stained sections of biopsy material obtained from patients taking omeprazole reveal a characteristic "hypertrophy" of the parietal cells; these are taller than the chief cells, and project, with convexly bulging apical cell membrane, into the lumen of the body glands, producing a serrated internal gland profile." | 7.68 | Omeprazole-induced pseudohypertrophy of gastric parietal cells. ( Bethke, B; Ritter, M; Rühl, G; Stolte, M, 1992) |
| "The aim of the present study was to investigate whether not only omeprazole but also lansoprazole leads to hypertrophy of the parietal cells of the gastric mucosa." | 5.09 | Treatment with lansoprazole also induces hypertrophy of the parietal cells of the stomach. ( Alexandridis, T; Meining, A; Seifert, E; Stolte, M, 2000) |
| "The results indicate that omeprazole treatment in chickens leads not only to trophic effects in the acid-producing gastric mucosa (probably because of the ensuing hypergastrinemia), as reported earlier, but also to growth of the parathyroid glands (both hypertrophy and hyperplasia) and to bone loss without affecting blood calcium values." | 3.69 | Growth of the parathyroid glands in omeprazole-treated chickens. ( Gagnemo-Persson, R; Håkanson, R; Persson, P; Sundler, F, 1994) |
| " Oral administration of a proton pump inhibitor, omeprazole, which induced hypertrophy of the gastric mucosa with hypergastrinemia in wild-type littermates, did not eliminate the gastric atrophy of the homozygotes." | 3.69 | G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. ( Chihara, K; Ito, M; Iwata, N; Kuno, J; Matsui, T; Minowa, O; Nagata, A; Noda, T; Takano, H, 1996) |
| "The histamine-producing enterochromaffin-like (ECL) cells in the acid-producing portion of the rat stomach responded to long-standing hypergastrinemia (omeprazole treatment daily for 8-10 weeks) with hypertrophy (and hyperplasia) and with a reduced number of granules and vesicles per unit cytoplasm." | 3.68 | Effect of omeprazole-evoked hypergastrinemia on ultrastructure of enterochromaffin-like cells in the stomach of portacaval-shunted rats. ( Chen, D; Håkanson, R; Sundler, F, 1993) |
| "Paraffin-embedded and haematoxylin-eosin-stained sections of biopsy material obtained from patients taking omeprazole reveal a characteristic "hypertrophy" of the parietal cells; these are taller than the chief cells, and project, with convexly bulging apical cell membrane, into the lumen of the body glands, producing a serrated internal gland profile." | 3.68 | Omeprazole-induced pseudohypertrophy of gastric parietal cells. ( Bethke, B; Ritter, M; Rühl, G; Stolte, M, 1992) |
| " Rats were dosed daily for 3 days with FLU at 500, 250, 62." | 1.33 | Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers. ( Caguyong, M; Cheng, O; Coe, KJ; Dai, X; He, Y; Nelson, SD; Roberts, CJ; Slatter, JG; Ulrich, RG, 2006) |
| "Omeprazole treatment for 4 weeks increased the oxyntic mucosal weight and thickness by 15-20%." | 1.31 | Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats. ( Björkqvist, M; Chen, D; de la Cour, CD; Gagnemo-Persson, C; Håkanson, R; Kitano, M; Norlén, P; Zhao, CM, 2001) |
| "Omeprazole is a long acting inhibitor of gastric acid secretion in different species including rat and dog." | 1.27 | Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa. ( Carlsson, E; Larsson, H; Mattsson, H; Ryberg, B; Sundell, G, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iqbal, FR | 1 |
| Goh, BS | 1 |
| Mazita, A | 1 |
| Hill, RK | 1 |
| Simpson, CB | 1 |
| Velazquez, R | 1 |
| Larson, N | 1 |
| Coe, KJ | 1 |
| Nelson, SD | 1 |
| Ulrich, RG | 1 |
| He, Y | 1 |
| Dai, X | 1 |
| Cheng, O | 1 |
| Caguyong, M | 1 |
| Roberts, CJ | 1 |
| Slatter, JG | 1 |
| Poe, DS | 1 |
| Grimmer, JF | 1 |
| Metson, R | 1 |
| Gagnemo-Persson, R | 1 |
| Håkanson, R | 5 |
| Sundler, F | 3 |
| Persson, P | 1 |
| Chen, D | 3 |
| Nagata, A | 1 |
| Ito, M | 1 |
| Iwata, N | 1 |
| Kuno, J | 1 |
| Takano, H | 1 |
| Minowa, O | 1 |
| Chihara, K | 1 |
| Matsui, T | 1 |
| Noda, T | 1 |
| Driman, DK | 1 |
| Wright, C | 1 |
| Tougas, G | 1 |
| Riddell, RH | 1 |
| Stolte, M | 2 |
| Meining, A | 1 |
| Seifert, E | 1 |
| Alexandridis, T | 1 |
| Zhao, CM | 2 |
| Bakke, I | 1 |
| Tostrup-Skogaker, N | 1 |
| Waldum, HL | 1 |
| Björkqvist, M | 1 |
| Norlén, P | 1 |
| Kitano, M | 1 |
| de la Cour, CD | 1 |
| Gagnemo-Persson, C | 1 |
| Sewing, KF | 1 |
| Bethke, B | 1 |
| Rühl, G | 1 |
| Ritter, M | 1 |
| Carlsson, E | 2 |
| Larsson, H | 2 |
| Mattsson, H | 1 |
| Ryberg, B | 2 |
| Sundell, G | 1 |
| Blom, H | 1 |
2 trials available for omeprazole and Hypertrophy
| Article | Year |
|---|---|
The role of proton pump inhibitors in adenoid hypertrophy in children.
Topics: Adenoids; Child; Child, Preschool; Double-Blind Method; Female; Humans; Hypertrophy; Male; Omeprazol | 2012 |
Treatment with lansoprazole also induces hypertrophy of the parietal cells of the stomach.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Cell Count; Double-Blind Method; Female; | 2000 |
13 other studies available for omeprazole and Hypertrophy
| Article | Year |
|---|---|
Pachydermia is not diagnostic of active laryngopharyngeal reflux disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Benzimid | 2004 |
Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers.
Topics: Androgen Antagonists; Animals; Aryl Hydrocarbon Hydroxylases; Cluster Analysis; Constitutive Androst | 2006 |
Laser eustachian tuboplasty: two-year results.
Topics: Adult; Anti-Ulcer Agents; Eustachian Tube; Female; Follow-Up Studies; Gastroesophageal Reflux; Heari | 2007 |
Growth of the parathyroid glands in omeprazole-treated chickens.
Topics: Animals; Bone Density; Chickens; DNA; Gastrins; Hyperplasia; Hypertrophy; Omeprazole; Organ Size; Pa | 1994 |
Effect of omeprazole-evoked hypergastrinemia on ultrastructure of enterochromaffin-like cells in the stomach of portacaval-shunted rats.
Topics: Animals; Enterochromaffin Cells; Gastrins; Hyperplasia; Hypertrophy; Male; Microscopy, Electron; Ome | 1993 |
G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo.
Topics: Animals; Atrophy; Chromaffin Cells; Chromogranin A; Chromogranins; DNA Probes; Gastric Mucosa; Gastr | 1996 |
Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cell Count; Cell Size; Humans; Hyperp | 1996 |
Functionally impaired, hypertrophic ECL cells accumulate vacuoles and lipofuscin bodies. An ultrastructural study of ECL cells isolated from hypergastrinemic rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Benzimidazoles; Cell Division; Cell Size; Enteroch | 2001 |
Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Digestive System; Drug Interactions; Gastrins; Hormone | 2001 |
[Two aspects of the contribution by Stolte et al., "Omeprazole-induced pseudohypertrophy of parietal cells", provide reason to comment].
Topics: Gastroscopy; Humans; Hypertrophy; Omeprazole; Parietal Cells, Gastric | 1992 |
Omeprazole-induced pseudohypertrophy of gastric parietal cells.
Topics: Cell Membrane; Cytological Techniques; Gastric Mucosa; Humans; Hypertrophy; Omeprazole; Parietal Cel | 1992 |
Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Carcinoid Tumor; Dogs; Female; Gastric Acid; Gastric Muc | 1986 |
Hypergastrinaemia produces trophic effects in stomach but not in pancreas and intestines.
Topics: Animals; Benzimidazoles; Cytoplasmic Granules; Female; Gastric Acid; Gastric Mucosa; Gastrins; Hyper | 1986 |