Page last updated: 2024-11-01

omeprazole and Headache

omeprazole has been researched along with Headache in 14 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"As can be expected, headache was reported less frequently in this study compared with clinical trials with lansoprazole."9.10Determinants of headache in lansoprazole users in The Netherlands: results from a nested case-control study. ( Claessens, AA; Heerdink, ER; Lamers, CB; Leufkens, HG; van Eijk, JT, 2002)
"This study was undertaken to compare the efficacy of lansoprazole (LAN)-based triple therapy with that of RBC-based dual therapy in H pylori-infected patients with duodenal ulcer."9.09Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study. ( Belmonte, A; Cavaliere, C; Ciliberto, E; Fiocca, R; Frandina, C; Giglio, A; Luzza, F; Pallone, F; Saccà, N; Trimboli, V, 2001)
"To examine dyspepsia symptom relief over 16 weeks and compare an omeprazole clinical management strategy with a commonly used combination of antacid-alginate followed by H2-antagonist."9.08The management of acid-related dyspepsia in general practice: a comparison of an omeprazole versus an antacid-alginate/ranitidine management strategy. Compete Research Group [corrected]. ( Evans, WM; Mason, I; Millar, LJ; Sheikh, RR; Taylor, MD; Todd, PL; Turbitt, ML, 1998)
" In this open-label study, the effect of lansoprazole 30 mg qd and naproxen 500 mg bid on the pharmacokinetic profile of methotrexate was investigated."6.71Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis. ( Amer, F; Andhivarothai, N; Kukulka, MJ; Vakily, M, 2005)
"As can be expected, headache was reported less frequently in this study compared with clinical trials with lansoprazole."5.10Determinants of headache in lansoprazole users in The Netherlands: results from a nested case-control study. ( Claessens, AA; Heerdink, ER; Lamers, CB; Leufkens, HG; van Eijk, JT, 2002)
"This study was undertaken to compare the efficacy of lansoprazole (LAN)-based triple therapy with that of RBC-based dual therapy in H pylori-infected patients with duodenal ulcer."5.09Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study. ( Belmonte, A; Cavaliere, C; Ciliberto, E; Fiocca, R; Frandina, C; Giglio, A; Luzza, F; Pallone, F; Saccà, N; Trimboli, V, 2001)
"To examine dyspepsia symptom relief over 16 weeks and compare an omeprazole clinical management strategy with a commonly used combination of antacid-alginate followed by H2-antagonist."5.08The management of acid-related dyspepsia in general practice: a comparison of an omeprazole versus an antacid-alginate/ranitidine management strategy. Compete Research Group [corrected]. ( Evans, WM; Mason, I; Millar, LJ; Sheikh, RR; Taylor, MD; Todd, PL; Turbitt, ML, 1998)
" The most common adverse events of headache, diarrhea, and nausea have been reported in fewer than 5% of patients treated with lansoprazole or omeprazole."4.80Safety profile of the proton-pump inhibitors. ( Reilly, JP, 1999)
"Nelfinavir was well tolerated when administered alone and when coadministered with omeprazole."2.73Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects. ( Crownover, PH; Damle, BD; Fang, AF; Glue, PW; Hewlett, D; LaBadie, RR, 2008)
" In this open-label study, the effect of lansoprazole 30 mg qd and naproxen 500 mg bid on the pharmacokinetic profile of methotrexate was investigated."2.71Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis. ( Amer, F; Andhivarothai, N; Kukulka, MJ; Vakily, M, 2005)
"Lansoprazole is a H+."2.68Lansoprazole versus ranitidine for the treatment of reflux oesophagitis. UK Lansoprazole Clinical Research Group. ( Bardhan, KD; Brocklebank, D; Hawkey, CJ; Long, RG; Morgan, AG; Moules, IK; Wormsley, KG, 1995)
"To estimate the rates of common adverse events in patients treated with the proton pump inhibitors omeprazole, lansoprazole and pantoprazole in general practice in England."1.31The rates of common adverse events reported during treatment with proton pump inhibitors used in general practice in England: cohort studies. ( Dunn, NR; Freemantle, S; Martin, RM; Shakir, S, 2000)
"Lansoprazole was mostly prescribed in patients with reflux oesophagitis (55."1.30A prospective follow-up study of 5669 users of lansoprazole in daily practice. ( Claessens, A; Heerdink, E; Lamers, CB; Leufkens, H; van Eijk, J, 1997)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (50.00)18.2507
2000's7 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vakily, M1
Amer, F1
Kukulka, MJ1
Andhivarothai, N1
Huntoon, MA1
Watson, JC1
Singh, K1
Dickinson, L1
Chaikan, A1
Back, D1
Fletcher, C1
Pozniak, A1
Moyle, G1
Nelson, M1
Gazzard, B1
Herath, D1
Boffito, M1
Fang, AF1
Damle, BD1
LaBadie, RR1
Crownover, PH1
Hewlett, D1
Glue, PW1
Bardhan, KD1
Hawkey, CJ1
Long, RG1
Morgan, AG1
Wormsley, KG1
Moules, IK1
Brocklebank, D1
Sontag, SJ1
Schnell, TG1
Chejfec, G1
Kurucar, C1
Karpf, J1
Levine, G1
Meeuwisse, EJ1
Groen, FC1
Dees, A1
Smit, GH1
Ottervanger, JP1
Leufkens, H1
Claessens, A1
Heerdink, E1
van Eijk, J1
Lamers, CB2
Mason, I1
Millar, LJ1
Sheikh, RR1
Evans, WM1
Todd, PL1
Turbitt, ML1
Taylor, MD1
Reilly, JP1
Martin, RM1
Dunn, NR1
Freemantle, S1
Shakir, S1
Luzza, F1
Giglio, A1
Ciliberto, E1
Belmonte, A1
Cavaliere, C1
Saccà, N1
Frandina, C1
Fiocca, R1
Trimboli, V1
Pallone, F1
Claessens, AA1
Heerdink, ER1
van Eijk, JT1
Leufkens, HG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I, Randomized, Double-blind, Placebo- and Positive-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics/Pharmacodynamics (PK/PD) of Multiple Oral Doses of H008 (Carenoprazan Hydrochloride Tablets) in Healthy Volunteers[NCT05050188]Phase 124 participants (Actual)Interventional2021-06-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for omeprazole and Headache

ArticleYear
Safety profile of the proton-pump inhibitors.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Dec-01, Volume: 56, Issue:23 Suppl 4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Diarrhea; Drug Interactions; Gastric Muc

1999

Trials

8 trials available for omeprazole and Headache

ArticleYear
Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents

2005
Pharmacokinetics and safety of saquinavir/ritonavir and omeprazole in HIV-infected subjects.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:6

    Topics: Adult; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Headache; HIV Infec

2008
Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects.
    Pharmacotherapy, 2008, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Li

2008
Lansoprazole versus ranitidine for the treatment of reflux oesophagitis. UK Lansoprazole Clinical Research Group.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Double-Blind Method; Esophagitis, Peptic; Foll

1995
Lansoprazole heals erosive reflux oesophagitis in patients with Barrett's oesophagus.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Barrett Esophagus; Double-Blind Method; Enzyme Inhibitors;

1997
The management of acid-related dyspepsia in general practice: a comparison of an omeprazole versus an antacid-alginate/ranitidine management strategy. Compete Research Group [corrected].
    Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:3

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Aged, 80 and over; Alginates; Anti-Ulcer Agents; Biocompati

1998
Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study.
    Clinical therapeutics, 2001, Volume: 23, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Anti-Ulcer Agents; Bismuth; Clarit

2001
Determinants of headache in lansoprazole users in The Netherlands: results from a nested case-control study.
    Drug safety, 2002, Volume: 25, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Age Factors; Aged; Case-Control Studies;

2002

Other Studies

5 other studies available for omeprazole and Headache

ArticleYear
Intracranial hypotension following motor vehicle accident: an overlooked cause of post-traumatic head and neck pain?
    Pain practice : the official journal of World Institute of Pain, 2007, Volume: 7, Issue:1

    Topics: Accidents, Traffic; Analgesics; Aspirin; Blood Patch, Epidural; Diplopia; Drug Therapy, Combination;

2007
Lethargy with omeprazole.
    BMJ (Clinical research ed.), 1997, Feb-15, Volume: 314, Issue:7079

    Topics: Dizziness; Enzyme Inhibitors; Headache; Humans; Male; Middle Aged; Omeprazole; Sleep Stages

1997
A prospective follow-up study of 5669 users of lansoprazole in daily practice.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agen

1997
Rabeprazole.
    The Medical letter on drugs and therapeutics, 1999, Nov-19, Volume: 41, Issue:1066

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adenosine Triphosphatases; Anti-Ulcer Agent

1999
The rates of common adverse events reported during treatment with proton pump inhibitors used in general practice in England: cohort studies.
    British journal of clinical pharmacology, 2000, Volume: 50, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Adverse Drug Reaction Reporting Syst

2000