Page last updated: 2024-11-01

omeprazole and Gastroparesis

omeprazole has been researched along with Gastroparesis in 1 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Gastroparesis: Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

Research Excerpts

ExcerptRelevanceReference
"To compare pharmacokinetics between immediate and delayed-release omeprazole in patients with GERD associated with gastroparesis."9.14Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis. ( Eversmann, J; Mann, S; Wo, JM, 2010)
"To compare pharmacokinetics between immediate and delayed-release omeprazole in patients with GERD associated with gastroparesis."5.14Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis. ( Eversmann, J; Mann, S; Wo, JM, 2010)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wo, JM1
Eversmann, J1
Mann, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Patients With Heartburn Associated With Gastroparesis[NCT00492622]Phase 412 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Area Under the Curve for Omeprazole Plasma Concentration

The area under the curve for omeprazole concentration-time curve for immediate release and delayed release omeprazole. (NCT00492622)
Timeframe: 0 to 5 hrs after the study drug was ingested on treatment day 7

Interventionmg*h/mL (Mean)
All Study Participants Immediate Release Arm3842
All Study Subjects Delayed Release Arm3745

Maximal Concentration of Omerazole

Maximal concentration of immediate-release vs. delayed-release omeprazole (NCT00492622)
Timeframe: 10, 20, 30, 45, 60, 90, 120, 150, 180, 210, 240 and 300 min after the study drug was ingested on day 7 of treatment

Interventionng/mL plasma (Mean)
All Study Participants Immediate Release Arm1979
All Study Subjects Delayed Release Arm1625

Time to Maximal Omeprazole Concentration (Tmax)

Time to max concentration for Immediate release vs. Delayed release omeprazole (NCT00492622)
Timeframe: 10, 20, 30, 45, 60, 90, 120, 150, 180, 210, 240 and 300 min after the study drug was ingested on day 7 of treatment

Interventionminutes (Mean)
All Study Participants Immediate Release Arm32
All Study Subjects Delayed Release Arm97

Trials

1 trial available for omeprazole and Gastroparesis

ArticleYear
Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis.
    Alimentary pharmacology & therapeutics, 2010, Feb-15, Volume: 31, Issue:4

    Topics: Anti-Ulcer Agents; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Female; Gastri

2010